A5058795288- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Infant Health and Development
- IL-33, ST2, and ILC Pathways
- Exercise and Physiological Responses
- Digestive system and related health
- Biochemical Analysis and Sensing Techniques
- Probiotics and Fermented Foods
- Nutrition, Genetics, and Disease
- Hepatitis B Virus Studies
- Infant Nutrition and Health
- Birth, Development, and Health
- Pediatric health and respiratory diseases
- Salmonella and Campylobacter epidemiology
- Circadian rhythm and melatonin
- Blood groups and transfusion
- Tryptophan and brain disorders
- Fatty Acid Research and Health
- Health, Environment, Cognitive Aging
- Telomeres, Telomerase, and Senescence
- Clinical Nutrition and Gastroenterology
- Vibrio bacteria research studies
University of Ulsan
2018-2024
Ulsan College
2018-2024
Asan Medical Center
2020-2023
Chosun University
2017
Korean Red Cross
2012
Purpose:The roles of gut microbiota on the natural course atopic dermatitis (AD) are not yet fully understood.We investigated whether composition and function short-chain fatty acids (SCFAs) at 6 months age could affect AD up to 24 in early childhood.Methods: Fecal samples from 132 infants were analyzed using pyrosequencing, including 84 healthy controls, 22 transient 26 persistent subjects Cohort for Childhood Origin Asthma Allergic Diseases (COCOA) birth cohort.The functional profile...
Abstract Background Ruminococcus gnavus ( R . ) are mucin‐degrading gut bacteria that play a key role in the early colonization of by serving as endogenous sources nutrients. They can also influence immune development. We had previously reported lower abundance infants with atopic dermatitis (AD) compared healthy subjects. However, underlying mechanisms remain unclear. In this study, we investigated effect orally administered on antibiotic treatment‐induced dysbiosis (and mechanism) mouse...
The gut microbiome influences the development of allergic diseases during early childhood. However, there is a lack comprehensive understanding microbiome-host crosstalk. Here, we analyzed influence dynamics in childhood on atopic dermatitis (AD) and potential interactions between host that control this homeostasis. We 346 fecal samples (6–36 months; 112 non-AD, 110 mild AD, 124 moderate to severe AD) from Longitudinal Cohort for Childhood Origin Asthma Allergic Disease birth cohort. were...
Abstract Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires expertise dermatology. Recent studies have indicated that host genes–microbial interactions the gut contribute to human diseases including AD. We sought develop an accurate and automated pipeline for AD based on transcriptome microbiota data. Using these data of 161 subjects patients healthy controls, we trained machine learning classifier predict risk found could accurately differentiate with...
Abstract Food allergy (FA) is a widespread issue, affecting as many 10% of the population. Over past two to three decades, prevalence FA has been on rise, particularly in industrialized and westernized countries. complex, multifactorial disease mediated by type 2 immune responses involving environmental genetic factors. However, precise mechanisms remain inadequately understood. Metabolomics potential identify endotypes, which could beneficially promote personalized prevention treatment. A...
Mechanisms underlying persistent food allergy (FA) are not well elucidated. The intestinal mucosa is the primary exposure route of allergens. However, no study has examined metabolites associated with FA persistence. goal this was to investigate and microbiomes in early life that aid determining development persistence FA.We identified metabolomic alterations stool infants according by mass spectrometry-based untargeted metabolome profiling. targeted analysis bile acid microbiome performed....
Hepatitis C virus (HCV) remains a worldwide health-care burden. Prevalence rates vary and the distribution of genotypes depends on geographical location. Here, recent prevalence HCV infections among Korean blood donors were studied.Between February 2005 December 2009, total 11,064,532 screened for anti-HCV 11,412,690 RNA. genotyping was conducted 748 with RNA by using line probe assay (VERSANT Genotype 2.0 Assay, Bayer Healthcare, USA) after amplification 5'-untranslated core regions...
Purpose: Interleukin (IL)-17 variants and perturbations in the gut microbiota may influence development of atopic dermatitis (AD).However, unifying principles for host microbe interaction remains unclear.We sought to investigate whether IL-17 affect AD infancy.Methods: Composition was analyzed fecal samples from 99 normal healthy 61 infants at 6 months age.The associations between total immunoglobulin E (IgE), scoring (SCORAD), short-chain fatty acids, transcriptome functional profile...
Salmonella enterica infects a broad range of host animals, and zoonostic infection threatens both public health the livestock meat processing industries. Many antimicrobials have been developed to target envelope that performs essential bacterial functions; however, there are very few analytical methods can be used validate efficacy these antimicrobials. In this study, develop potential biosensor for stress, we examined transcription S. serovar typhimurium spy gene, ortholog which in...
Prenatal maternal stress affects offspring's atopic dermatitis (AD) development, which is thought to be mediated by the oxidative stress. We aimed evaluate difference in leukocyte telomere length (LTL), a marker for exposure stress, according prenatal and later AD development.From birth cohort (the COhort Childhood Origin of Asthma allergic diseases) that had displayed good epidemiologic association between development offspring, we selected 68 pairs samples from 4 subject groups based on...
We present the complete genome sequence of Enterococcus faecalis strain HL1, isolated from infant feces. E. gains significant attention for its therapeutic potential. The HL1 consists a 2.7 Mb circular chromosome with no plasmids, and it contains total 2,546 predicted coding genes.
Exposure to prenatal stress is associated with offspring allergic-disease development, and oxidative may mediate this relationship.We aimed evaluate whether leukocyte telomere length (LTL) shortening, a marker for exposure stress, in early life increased risk of asthma development during the preschool period.We assessed follow-up clinical data subgroup from birth cohort whose LTLs had been measured cord-blood 1-year peripheral-blood samples. We examined would be at age 2-4 years.The 84...
Gut microbiota dysbiosis is linked to the development and responses of immune system can play an important role in onset allergic diseases including atopic dermatitis (AD). This study investigated association between host genetics gut AD.A global gene expression profiling epithelial colonocytes, genetic variations analysis, microbial composition analysis were performed.This identified upregulation PTGR2 (p = .028), a involved prostaglandin catalysis inflammatory responses, as potential risk...