A5087029604- Hydrology and Drought Analysis
- Climate variability and models
- Meteorological Phenomena and Simulations
- Technology and Data Analysis
- Advanced Multi-Objective Optimization Algorithms
- Financial Risk and Volatility Modeling
- Mesenchymal stem cell research
- Flood Risk Assessment and Management
- Gaussian Processes and Bayesian Inference
- Computer Graphics and Visualization Techniques
- Quality and Supply Management
- Optimal Experimental Design Methods
- Advanced Vision and Imaging
- Advanced Statistical Methods and Models
- Precipitation Measurement and Analysis
- Soil Geostatistics and Mapping
- Ecology and Conservation Studies
- Fault Detection and Control Systems
- Ecology and Vegetation Dynamics Studies
- Statistical Methods and Inference
- Spatial and Panel Data Analysis
- Statistical Distribution Estimation and Applications
- Environmental Sustainability in Business
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
Chonnam National University
2015-2025
Korea University
2025
Chonnam National University Hospital
2020-2024
Kyungwoon University
2024
University of Ulsan
2024
Kwangwoon University
2022-2024
PanGen Biotech (South Korea)
2005-2023
Dankook University Hospital
2023
National Institute of Ecology
2018-2022
Dankook University
2008-2022
Prominent techniques such as real-time polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and rapid kits are currently being explored to both enhance sensitivity reduce time for diagnostic tests. Existing commercial molecular methods typically take several hours, while immunoassays can range from hours tens of minutes. Rapid diagnostics crucial in Point-of-Care Testing (POCT). We propose an approach that integrates a time-series deep learning architecture AI-based...
Senescent human diploid fibroblasts do not respond to growth factors like epidermal factor (EGF), although they have a normal level of receptors and downstream signaling molecules. To examine the mechanism attenuation, we investigated Erk activation after EGF stimulation in senescent cells. cells did phosphorylate Erk-1/2 stimulation, whereas young did. In those cells, found an increased caveolin proteins strong interactions between caveolin-1 receptor. Electron microscopic analysis...
BACKGROUND Adipose-derived stem cells (ADSCs) and their secretory factors can stimulate collagen synthesis migration of fibroblasts during the wound healing process. Conventional treatments for skin aging, such as lasers topical regimens, induce new via activation dermal or growth factors. Considering results our previous study, ADSCs also be used treatment aging. OBJECTIVE The aim was to verify effectiveness METHODS We analyzed intradermally injected (1 × 106 in 1 mL Hanks' buffered salt...
Since many lateral flow assays (LFA) are tested daily, the improvement in accuracy can greatly impact individual patient care and public health. However, current self-testing for COVID-19 detection suffers from low accuracy, mainly due to LFA sensitivity reading ambiguities. Here, we present deep learning-assisted smartphone-based (SMARTAI-LFA) diagnostics provide accurate decisions with higher sensitivity. Combining clinical data learning two-step algorithms enables a cradle-free on-site...
It has been demonstrated that adipose-derived stem cells (ADSCs) secrete cytokines and exhibit diverse pharmacological actions. The present study examined the unknown action of ADSCs regarding whitening effects. A conditioned medium (ADSC-CM) was harvested effect ADSC-CM studied in melanoma B16 cells. treatment inhibited synthesis melanin activity tyrosinase a dose dependent manner. To clarify underlying mechanisms ADSCs, protein levels melanogenic proteins were measured by Western blot....
Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson's disease (PD) and contribute to sporadic PD. LRRK2 contains Guanosine-5'-triphosphate (GTP) binding, GTPase kinase activities that have been implicated neuronal degeneration of PD pathogenesis, making LRRK2, a potential drug target. To date, there is no disease-modifying slow published GTP domain inhibitor. Here, biological functions two novel GTP-binding inhibitors were examined cell mouse models....
Hyporesponsiveness to growth factors is one of the fundamental characteristics senescent cells. We previously reported that up-regulation caveolin attenuates factor response and subsequent downstream signal cascades in human diploid fibroblasts. Therefore, present experiment, we investigated modulation status cells determine effect on mitogenic signaling efficiency cell cycling. reduced level caveolin-1 fibroblasts using its antisense oligonucleotides small interfering RNA, this resulted...
Abstract This paper examines the usefulness of non‐stationary generalized extreme value (GEV) distribution in modelling rainfall. We modelled annual maxima daily (AMP1) and 2‐day (AMP2) rainfall data observed during summer rainy season, dating up to 2007 28 stations South Korea. fitted GEV for each location. The location parameter was formulated as a function time explore temporal trends maximum precipitation over course climatic change predict future behaviours. found evidence...
ResultsZZAccording to the results, K-BIS-11-R had an acceptable test-retest reliability and internal consistency reliability. In addition, total score second-order subscale showed significant correlation with Conners’ Adult attention deficit/hyperactivity disorder Rating Scale-Korean Buss & Durkee Hostility Inventory. no difference was observed between demographic variables. Thus, K-BIS11-R transformed standard score.
Mesenchymal stem cells are widely used for transplantation into the injured spinal cord in vivo model and safety, many human clinical trials continuing to promote improvements of motor sensory functions after injury. Yet exact mechanism these remains undefined. Neurogenic bladder following injury is main problem decreasing quality life patients with injury, but there no clear data using cell improvement neurogenic studies setting. The purpose this study was delineate effect mesenchymal...
To describe the features and clinical implications of computed tomography (CT), positron emission (PET), percutaneous needle aspiration biopsy (PCNB) in pulmonary nontuberculous mycobacterial (NTM) disease manifesting as a solitary nodule, mass, or mass-like consolidation mimicking malignancy. Among cohort 388 patients with NTM disease, 14 clinically radiologically suspected lung cancer were included our study. Two chest radiologists evaluated CT features, including lesion type (nodule,...
A model weighting scheme is important in multi-model climate ensembles for projecting future changes. The output typically needs to be bias corrected before it can used. When a bias-correction (BC) applied, equal weights are usually derived because some BC methods cause the observations and historical simulation match perfectly. This sometimes criticized does not take into account performance. Unequal reflecting performance may obtained from raw data applied. However, we have observed that...