A5017745623- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Cellular Mechanics and Interactions
- Ion Channels and Receptors
- Spaceflight effects on biology
- Olfactory and Sensory Function Studies
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Dermatology and Skin Diseases
- Ultrasound and Hyperthermia Applications
- Neuroscience and Neuropharmacology Research
- Food Allergy and Anaphylaxis Research
- Caveolin-1 and cellular processes
- Ion Transport and Channel Regulation
- Biochemical effects in animals
- Cardiomyopathy and Myosin Studies
- Urinary Bladder and Prostate Research
- Chromatography in Natural Products
- Urticaria and Related Conditions
- Tardigrade Biology and Ecology
- Magnetic and Electromagnetic Effects
- Neurogenesis and neuroplasticity mechanisms
- Advanced Energy Technologies and Civil Engineering Innovations
- Medicinal Plants and Neuroprotection
Korea Institute of Brain Science
2017-2025
Korea Institute of Science and Technology
2017-2025
Korean Association Of Science and Technology Studies
2019-2025
Korea University of Science and Technology
2022-2025
Bio-Medical Science (South Korea)
2022-2025
Seoul National University
2015-2024
Korea University
2024
University College London
2013
Aberrant mechanosensation has an important role in different pain states. Here we show that Epac1 (cyclic AMP sensor) potentiation of Piezo2-mediated mechanotransduction contributes to mechanical allodynia. Dorsal root ganglia mRNA levels increase during neuropathic pain, and nerve damage-induced allodynia is reduced Epac1-/- mice. The Epac-selective cAMP analogue 8-pCPT sensitizes mechanically evoked currents sensory neurons. Human Piezo2 produces large gated are enhanced by the activation...
Significance Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate gland, a common disease in elderly men. Excessive testosterone considered to cause BPH. However, its etiologic mechanisms are elusive. We found that ANO1, Ca 2+ -activated Cl − channel, essential for testosterone-induced ANO1 was highly expressed dihydrotestosterone (DHT)-treated epithelial cells. The selective knockdown suppressed DHT-induced cell proliferation. Surprisingly, we there were...
Gold nanoparticles (AuNPs) are valuable tools in pharmacological and biological research, offering unique properties for drug delivery the treatment of neurodegenerative diseases. This study investigates potential gold loaded with afzelin, a natural chemical extracted from Ribes fasciculatum, to enhance its therapeutic effects overcome limitations using compounds regarding low productivity. We hypothesized that combined AuNPs afzelin (AuNP-afzelin) would remarkably enforce neuroprotective...
The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show tentonin 3 (TTN3/TMEM150C), cation channel activated by mechanical strokes, essential for detecting changes the aortic arch. TTN3 was expressed nerve terminals arch and nodose ganglion (NG) neurons. Genetic ablation of Ttn3 induced ambient hypertension, tachycardia, fluctuations, impaired baroreflex...
Korean Red Ginseng—a steamed root of Panax ginseng Meyer—has long been used as a traditional medicine in Asian countries. Its antipruritic effect was recently found, but no molecular mechanisms were revealed. Thus, the current study focused on determining underlying mechanism Ginseng extract (RGE) against histamine-induced itch at peripheral sensory neuronal level. To examine RGE, we performed vivo scratching behavior test mice, well vitro calcium imaging and whole-cell patch clamp...
Mechanically activating (MA) channels transduce numerous physiological functions. Tentonin 3/TMEM150C (TTN3) confers MA currents with slow inactivation kinetics in somato- and barosensory neurons. However, questions were raised about its role as a Piezo1 regulator potential channel pore. Here, we demonstrate that purified TTN3 proteins incorporated into the lipid bilayer displayed spontaneous pressure-sensitive currents. These conserved across vertebrates differ from activation threshold...
Anisotropically organized neural networks are indispensable routes for functional connectivity in the brain, which remains largely unknown. While prevailing animal models require additional preparation and stimulation-applying devices have exhibited limited capabilities regarding localized stimulation, no vitro platform exists that permits spatiotemporal control of chemo-stimulation anisotropic three-dimensional (3D) networks. We present integration microchannels seamlessly into a...
Several studies have documented the broad-spectrum bioactivities of a lotus seed (Plumula nelumbinis [PN]) green embryo extract. However, specific bioactive components and associated molecular mechanisms remain largely unknown. This study aimed to identify ion channel-activating PN extracts. Using fluorometric imaging patch-clamp recordings, extracts were screened for calcium channel activation in dorsal root ganglion (DRG) neurons. The TRPV1 channels DRG neurons strongly activated by...
<title>Abstract</title> Mechanically activating (MA) channels transduce numerous physiological functions. Tentonin 3/TMEM150C (TTN3) confers MA currents with slow-inactivation kinetics in somato- and baro-sensory neurons. Despite the distinct when heterologously expressed, whether TTN3 forms a channel pore is unknown. Here, we demonstrate that purified proteins incorporated into lipid bilayer exhibited spontaneous pressure-sensitive currents. of unique were conserved throughout vertebrate...
<title>Abstract</title> Neurogenesis and interneuron integration are crucial for maintaining cortical circuit functionality. In the medial ganglionic eminences (MGE), ventral radial glia (vRG) predominantly generates somatostatin-expressing (SST+) interneurons through direct neurogenesis in neocortex. However, mechanism guiding vRG to asymmetrically divide produce either SST+ or intermediate progenitor (IP) remains unclear. This study identifies a novel subpopulation of vRG, characterized by...
Abstract Aim This investigation addresses Piezo1's expression and mechanistic role in dorsal root ganglion (DRG) neurons delineates its participation mechanical inflammatory pain modulation. Methods We analyzed patterns DRG utilized Piezo1‐specific shRNA to modulate activity. Electrophysiological assessments of mechanically activated (MA) currents behavioral analyses mouse models were conducted elucidate functional implications. Additionally, we investigated the excitability TRPV1‐expressing...
Mechanosensation begins with the sensing of pressure by mechanically activated (MA) channels in nerve endings dorsal root ganglion (DRG) neurons. Piezo1, a fast-inactivating MA channel, has surfaced to be involved pruriception. However, pressure-dependent activation mechanism and its physiological role mechanical pain remain unidentified. Here, we report that Piezo1 is expressed small DRG subpopulation, which largely positive for TRPV1 rather than MRGPRD, known nociceptors. To investigate...
Abstract Mechanosensation begins with sensing pressure by mechanically activated (MA) channels in the nerve endings of dorsal root ganglion (DRG) neurons. Piezos are first discovered MA mammals various mechanosensations. Piezo2’s function is mainly linked to light touch, nociception, and proprioception DRGs. However, involvement Piezo1 mechanical pain has remained uncertain. Here, we report that transcripts distinctively expressed DRGs whose population largely positive for Trpv1 . Similarly,...
Abstract Malformation during cortical development can disrupt the balance of excitatory and inhibitory neural circuits, contributing to various psychiatric developmental disorders. One critical factors networks is fine regulation neurogenesis through mechanical cues, such as shear stress substrate stiffness. Piezo1, a mechanically-activated channel, serves transducer for these regulating embryogenesis. However, specific cell-type expression patterns this channel have not yet been...