A5069949867- Metabolism, Diabetes, and Cancer
- Diabetes Management and Education
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mobile Health and mHealth Applications
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- Adrenal and Paraganglionic Tumors
- Pancreatic function and diabetes
- Diet and metabolism studies
- Pharmacogenetics and Drug Metabolism
- Food composition and properties
- Cancer, Hypoxia, and Metabolism
- Nutrition, Health and Food Behavior
- Liver Disease Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Soft tissue tumor case studies
- Hormonal Regulation and Hypertension
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Genetic Syndromes and Imprinting
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
Seoul National University Hospital
2014-2019
Seoul National University
2011-2018
OBJECTIVE This study evaluated the efficacy of a smartphone-based, patient-centered diabetes care system (mDiabetes) for type 2 that contains comprehensive modules glucose monitoring, diet, physical activity, and clinical decision support system. RESEARCH DESIGN AND METHODS We conducted 24-week, multicenter, randomized controlled trial with adult patients inadequately diabetes. The were randomly assigned to mDiabetes group or paper logbook (pLogbook) group. primary end point was difference...
We developed a patient-centered, smartphone-based, diabetes care system (PSDCS). This study aims to test the feasibility of glycosylated hemoglobin (HbA1c) reduction with PSDCS.This was single-arm pilot study. The participants type 2 mellitus were instructed use PSDCS, which integrates Bluetooth-connected glucometer, digital food diary, and wearable physical activity monitoring device. primary end point change in HbA1c from baseline after 12-week intervention.Twenty-nine patients aged...
Effective medicines have not been introduced for insulin resistance-related fatty liver. The efficacy and safety of treatment between a combination metformin carnitine-orotate complex alone in 12-week, double-blind, randomized, placebo-controlled study on drug-naïve patients with impaired glucose metabolism liver were compared.Fifty-two fasting 100-240 mg/dL or glycosylated hemoglobin (HbA1c) ≥ 6.0% alanine aminotransferase (ALT) 40-250 IU/L randomized to receive (250 mg t.i.d.), t.i.d.)...
Background Latent autoimmune diabetes in adults (LADA) refers to a specific type of characterized by adult onset, presence islet auto-antibodies, insulin independence at the time diagnosis, and rapid decline β-cell function. The prevalence LADA among patients with 2 varies from 2% 20% according study population. Since most studies on performed Korea were conducted who had been tested for anti-glutamic acid decarboxylase antibody (GADAb), selection bias could not be excluded. In this study,...
Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results maturity-onset diabetes of young (MODY) 5, which is characterized by gradual impairment insulin secretion. However, functional role HNF-1β secretion and glucose metabolism not fully understood. We identified a family with early-onset that fulfilled criteria MODY. Sanger sequencing revealed heterozygous P159L (CCT to CTT codon 159 DNA-binding domain) mutation HNF1B was segregated according affected status. To...
Improving Effect of the Acute Administration Dietary Fiber-
Subjects with normal glucose tolerance (NGT) who have a high 1-hour postload plasma level (≥155 mg/dL; NGT 1 hour-high) been shown to be at higher risk for type 2 diabetes than subjects hour-low (<155 mg/dL). We compared β-cell function in hour-high, hour-low, and impaired (IGT).We classified into (n=149), hour-high (n=43), IGT (n=52). The was assessed based on insulinogenic index (IGI), oral disposition (DI), insulin secretion-sensitivity index-2 (ISSI-2).Insulin sensitivity comparable...
Clinically inapparent adrenal masses are incidentally detected after imaging studies conducted for reasons other than the evaluation of glands.They have frequently been referred to as incidentalomas.In preparation a National Institutes Health State-of-the-Science Conference on this topic, extensive literature research, including Medline, BIOSIS, and Embase between 1966 July 2002, well references published metaanalyses selected review articles identified more 5400 citations.Based 699 that...
We aimed to investigate the effects of gemigliptin, a dipeptidyl peptidase‐4 inhibitor, on postprandial lipoprotein levels and endotoxemia in randomized, double‐blind, placebo‐controlled, crossover study. Ten people with type 2 diabetes mellitus ( T2DM ), inadequately controlled oral antidiabetic medications and/or lifestyle modification, were randomized gemigliptin or placebo for 4 weeks. At end each treatment phase, study participants underwent high‐fat meal tolerance test needle...
Background: Bile acids were important for the regulation of cholesterol homeostasis.Thyroid hormone increased expression CYP7A1 (cholesterol 7α-hydroxylase), catalyzing first step in biosynthesis bile acids.However, effect thyroid on acid export has not been previously assessed.The principal objective this study is to evaluate effects salt pump (BSEP).Methods: Thyroid hormone, T3 (1 mg/g) was administered male mice via intraperitoneal injection.After 6 hours and 5 days treatment, we measured...
Background:The objective of this study is to demonstrate the relationship between volume a parathyroid adenoma and preoperative biochemical parameters in patients undergoing surgery for primary hyperparathyroidism.Methods: The medical records 68 who underwent parathyroidectomy single were retrospectively reviewed.The was estimated using its measured size mathematical formula.The correlation laboratory data assessed.Results: There no correlations serum calcium, alkaline phosphatase hormone...
A 75-g oral glucose tolerance test (OGTT) is a sensitive in most populations for diagnosis of type 2 diabetes mellitus (T2DM) and commonly used to identify high-risk individuals T2DM [1]. The diagnostic criteria define as fasting ≥126 mg/dL or 2-hour challenge ≥200 mg/dL, but not including 1-hour level. Recently, data obtained population studies have suggested that level after OGTT can provide better predictor development than [2]. And, subjects with levels ≥155 normal (NGT high) been...
Ectopic adrenocorticotropic hormone (ACTH) syndrome is mostly associated with neuroendocrine tumors and small cell carcinoma of the lung.This prostate cancer rare has been reported in only a few cases.We report patient ectopic ACTH production metastatic cancer.A 70-year-old was admitted to our hospital septic shock.He had history hormonal therapy transurethral prostatectomy.Adrenocortical function checked due consistent fever poor general condition, which revealed markedly increased levels...