A5027486291- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Erythropoietin and Anemia Treatment
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Hypoxia, and Metabolism
- Protein purification and stability
- Autophagy in Disease and Therapy
- Biosimilars and Bioanalytical Methods
- Neurological Disease Mechanisms and Treatments
- Microbial Community Ecology and Physiology
- Histone Deacetylase Inhibitors Research
- Sports Performance and Training
- Epigenetics and DNA Methylation
- Chronic Lymphocytic Leukemia Research
- Ubiquitin and proteasome pathways
- Redox biology and oxidative stress
- Physiological and biochemical adaptations
- Endoplasmic Reticulum Stress and Disease
- Intracerebral and Subarachnoid Hemorrhage Research
- Animal Genetics and Reproduction
- Lower Extremity Biomechanics and Pathologies
- Plant Disease Resistance and Genetics
- Sirtuins and Resveratrol in Medicine
- Neurobiology and Insect Physiology Research
- Sports injuries and prevention
Chung-Ang University
2017-2024
Suwon Research Institute
2017
Ajou University
2008-2015
Shinsung University
2015
Boryung Pharma (South Korea)
2009
Abstract Mitochondrial complex II defect has recently been implicated in cellular senescence and the ageing process of which a critical phenotype is retardation arrest growth. However, underlying mechanisms how affects growth, remain unclear. In this study, we investigated effect inhibition using subcytotoxic dose (400 µM) 2‐thenoyltrifluoroacetone (TTFA), conventional inhibitor, on cell cycle progression. TTFA directly decreased KCN‐sensitive respiration rate to 67% control disrupted...
Nutritional condition during the juvenile growth period considerably affects final adult size. The insulin/insulin-like factor signaling (IIS)/target of rapamycin (TOR) nutrient-sensing pathway is known to regulate and metabolism in response nutritional conditions. However, there limited information on how endocrine pathways communicate different metabolic organs organismal growth. Here, we show that Imaginal morphogenesis protein-Late 2 (Imp-L2), a Drosophila homolog insulin-like...
Minocycline is a semi-synthetic tetracycline derivative antibiotic that has received increasing attention for its non-antibiotic properties, mainly anti-inflammatory, tumor-suppressive, and neuroprotective effects. Drosophila widely used genetically tractable model organism studying organismal aging by virtue of short lifespan ease cultivation. In this study, we examined the effects minocycline on associated traits. Minocycline-supplemented food significantly extended in both Canton S w1118...
Although mitochondrial dysfunction has been implicated in tumor metastasis, it is unclear how regulates cell aggressiveness. We have reported previously that human hepatoma cells harboring defects high invasion activity via increased claudin-1 (Cln-1) expression. In this study, we demonstrated respiratory induced Cln-1 transcription reactive oxygen species (ROS)-mediated heat shock factor 1 (HSF1) activation, which contributed to invasiveness. first confirmed the inverse relationship between...
Minocycline is a semi-synthetic tetracycline derivative antibiotic that has been examined for its non-antibiotic properties, such as anti-inflammatory, tumor-suppressive, and neuroprotective effects. In this study, we found feeding minocycline to Drosophila improves proteostasis during organismal aging. Poly-ubiquitinated protein aggregates increase in the flight muscles flies age, which are reduced response feeding. increases expression of several autophagy genes activity...
Aging is often accompanied by a decline in proteostasis, manifested as an increased propensity for misfolded protein aggregates, which are prevented quality control systems, such the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy. Although role of UPS autophagy slowing age-induced proteostasis has been elucidated, limited information available on how these pathways can be activated collaborative manner to delay proteostasis-associated aging. Here, we show that activation via...
Jump training helps increase the muscle power by improving strength and reaction time of in operation. The purpose this study was to identify effects strengthening, stretching exercise meditation on electromyographic (EMG) onset timing rectus femoris gastrocnemius during vertical jump performance.