A5068353559- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Breast Cancer Treatment Studies
- Trauma Management and Diagnosis
- Aortic aneurysm repair treatments
- Coronary Artery Anomalies
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Airway Management and Intubation Techniques
- Spinal Fractures and Fixation Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- GDF15 and Related Biomarkers
- Management of metastatic bone disease
- Synthesis and Biological Evaluation
- FOXO transcription factor regulation
- Brain Metastases and Treatment
- Nutrition and Health in Aging
- Radioactive Decay and Measurement Techniques
Jeonbuk National University
2014-2024
Chonbuk National University Hospital
2008-2023
Konkuk University
2023
Dong-A University
2023
Ewha Womans University
1987-2021
Kookmin University
2020
Kyung Hee University
2015-2019
Kyungpook National University
2019
University of Southern California
2017-2018
Biomedical Research Institute
2018
Fasting reduces glucose levels and protects mice against chemotoxicity, yet drugs that promote hyperglycemia are widely used in cancer treatment. Here, we show dexamethasone (Dexa) rapamycin (Rapa), commonly administered to patients, elevate sensitize cardiomyocytes the drug doxorubicin (DXR). Such toxicity can be reversed by reducing circulating fasting or insulin. Furthermore, injections alone fasting-dependent protection DXR mice, indicating elevated mediates, at least part, sensitizing...
Rationale: Mitochondrial dysfunction is a key factor in the pathogenesis of Parkinson's disease (PD).Accordingly, many aspects mitochondrial function have been studied as putative therapeutic target.Here we present novel strategy to promote and protect against by peptide encoded within genome, mitochondria-derived (MDP) humanin (HN).Methods: To test potential biomarker PD, measured protein levels circulating from plasma PD patients transgenic or neurotoxic mouse models PD.Next, aimed...
Antiplatelet resistance is known to be associated with symptomatic ischemic complication after endovascular coil embolization. The purpose of our study was evaluate the relationship between antiplatelet and clinically silent thromboembolic complications using DWI in patients who underwent embolization for unruptured intracranial aneurysm.Between October 2011 May 2013, 58 62 aneurysms were measured response VerifyNow assay elective an aneurysm posttreatment enrolled. Diffusion-positive...
Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by the selective loss of dopaminergic neurons within substantia nigra (SN). While precise etiology neuronal demise elusive, multiple lines evidence indicate that neuroinflammation involved in pathogenesis PD. We have previously demonstrated subcutaneous administration bee venom (BV) phospholipase A2 (bvPLA2) suppresses cell death PD mouse model. In present study, we established standardized...
Idiopathic pulmonary fibrosis (IPF) is a devastating and common chronic lung disease pathologically characterized by loss of epithelial cells activation fibroblasts myofibroblasts. The etiology IPF remains unclear the pathology poorly understood with no known efficacious therapy. PM014 an herbal extract that has been shown to have beneficial effects in diseases, which are likely exert anti-inflammatory bioactions. In present study, we observed bleomycin (BLM) caused increased inflammatory...
We report on the use of a multichannel time scaling technique suitable for determining half-life long-lived intermediate states by means correlation counting. Use method is demonstrated studying decay an isomer at 304 keV excitation energy using pressurized proportional counter and NaI(Tl) detection set-up. The measurement was 9000 s. Eighteen values electron capture efficiencies were obtained in region 1.4-12 keV. eighteen sets data fraction events, each set consisting 52 counting...
Objective Tracheostomy tube displacement may occur at any time in the course of patient management. Although an infrequent occurrence, such is potentially serious. The purpose this study was to evaluate advantages and complications stay suture technique tracheostomy. Study Design Prospective cohort study. Methods SST involves placement sutures between anterior tracheal wall skin order hasten formation a mature stoma. patients were divided into two groups. One group underwent tracheostomy...
A solitary fibrous tumor (SFT) is a mesenchymal fibroblastic inside the pleura, for which complete surgical resection standard treatment. For large SFTs, preoperative identification of tumor-feeding vessels using angiography important achieving without unexpected operative bleeding. Extensive adhesions can make difficult in limited window, and pulmonary may be required to achieve SFT resection. Herein, we report successful pleural 39-year-old man any complications 2-stage approach, ligation...
Promotion of mitophagy is considered a promising strategy for the treatment neurodegenerative diseases including Alzheimer's disease (AD). The development mitophagy-specific inducers with low toxicity and defined molecular mechanisms essential clinical application mitophagy-based therapy. aim this study was to investigate potential novel small-molecule inducer, ALT001, as AD.
The aim of this study was to evaluate a newly-designed mitral annuloplasty strip (the Mitra-Lift(®) strip) in patients undergoing valve repair for regurgitation (MR).A total 30 who underwent posterior moderately severe MR were evaluated study. (SA) consisted the use and suture supra-annular atrial wall 5.0 mm width annulus. In addition SA, six (20.0%) with tethered leaflets required leaflet augmentation. Improvement hemodynamic parameters fixed assessed.After all exhibited little or no MR,...
We examined perioperative predictors of sustained sinus rhythm (SR) in patients undergoing the Cox maze operation and concomitant cardiac surgery for structural heart disease.From October 1999 to December 2008, 90 with atrial fibrillation (AF) underwent other surgery. Eighty-nine patients, all except one postoperative death, were followed-up serial electrocardiographic studies, 24-hour Holter monitoring tests, regular echocardiographic studies.Eighty-nine divided into two groups according...
The purpose of this report is to describe the perioperative outcomes standard carotid endarterectomy (CEA) with general anesthesia, routine shunting, and tissue patching in symptomatic stenoses.Between October 2007 July 2011, 22 patients stenosis (male/female, 19/3; mean age, 67.2±9.4 years) underwent a combined total 23 CEAs using standardized technique. strict surgical protocol included anesthesia bifurcation shunting. 8-French Pruitt-Inahara shunt was used all patients.During ischemic...
Jong Bum Choi, M.D., Hun Kim, Hyun Kyu Park, Kyung Hwa Min Ho Ja Hong Kuh, and Jung Ku Jo, M.D.. Korean J Thorac Cardiovasc Surg 2013;46:249-55. https://doi.org/10.5090/kjtcs.2013.46.4.249
Despite recent advances in surgical techniques and perioperative management, the mortality of acute type A aortic dissection remains high.In a hospital with few operations, we retrospectively investigated whether simplified approach could obtain proper outcomes.Between October 2007 December 2016, performed emergency surgery 99 patients who had dissection, including replacement hemi-arch 62 (63%) total arch 32 (32%) root 7 (7%). Surgical strategy has been over time.We right axillary artery...
We describe a modified technique of tricuspid ring annuloplasty to reduce postoperative residual regurgitation in patients with functional regurgitation; first, an adjustable segmental is performed obtain coaptation the valve leaflets two 5-0 monofilament annular sutures, and then prosthetic same size as competent area implanted continuous 3-0 polypropylene sutures.
Globally, cardiac arrest (CA) is a leading cause of death and disability. Asphyxial CA (ACA)-induced kidney damage crucial factor in reducing the survival rate. The purpose this study was to investigate role antioxidant enzymes histopathological renal an ACA rat model at different time points. A total 88 rats were divided into five groups exposed except for sham group. To evaluate glomerular function oxidative stress, serum levels blood urea nitrogen (BUN) creatinine (Crtn) malondialdehyde...
The aim of the study was to evaluate role ramosetron for prevention chemoradiotherapy-induced nausea and vomiting (CRINV) in patients receiving upper abdominal irradiation with concurrent 5-fluorouracil chemotherapy. Between November 2006 April 2007, 25 pancreatico-biliary cancer underwent adjuvant chemoradiotherapy. A total dose 40 Gy delivered using 2 Gy/fraction, 5 days a week, weeks planned rest after 20 Gy. Concomitant (500 mg/m2/day i.v. bolus) administered first 3 each split course....