A5059708383- Photonic and Optical Devices
- Advanced Fiber Laser Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mechanical and Optical Resonators
- Photonic Crystal and Fiber Optics
- Advanced Fiber Optic Sensors
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Laser-Matter Interactions and Applications
- Semiconductor Lasers and Optical Devices
- Microfluidic and Bio-sensing Technologies
- Lung Cancer Treatments and Mutations
- Advanced Photonic Communication Systems
- Advanced Biosensing Techniques and Applications
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Fibroblast Growth Factor Research
- HER2/EGFR in Cancer Research
- Photonic Crystals and Applications
- Advanced optical system design
- Cellular Mechanics and Interactions
- Plasmonic and Surface Plasmon Research
Seoul National University
2007-2022
California Institute of Technology
2013-2021
Seoul National University Hospital
2018
Kyung Hee University
2018
University of Illinois Urbana-Champaign
2018
Government of the Republic of Korea
2017
Bioengineering Center
2017
Institute for Basic Science
2014
Kavli Energy NanoScience Institute
2013
New Generation University College
2006-2009
Abstract Short duration, intense pulses of light can experience dramatic spectral broadening when propagating through lengths optical fibre. This continuum generation process is caused by a combination nonlinear effects including the formation dispersive waves. Optical analogues Cherenkov radiation, these waves allow pulse to radiate power into distant region. In this work, efficient and coherent wave visible ultraviolet demonstrated in silica waveguides on silicon chip. Unlike fibre...
Supercontinuum generation is demonstrated in an on-chip silica spiral waveguide by launching 180 fs pulses from optical parametric oscillator at the center wavelength of 1330 nm. With a coupled pulse energy 2.17 nJ, broadest spectrum fundamental TM mode extends 936 to 1888 nm (162 THz) -50 dB peak. There good agreement between measured and simulation using generalized nonlinear Schrödinger equation.
The purpose of this study is to document infection and better understand current practice relating antibiotic use its effect in terminal cancer patients. We retrospectively reviewed patients with stage who were admitted Seoul National University Boramae Hospital for symptom control only, finally died between March 2003 April 2004. A total 141 enrolled. Mean duration from admission death was 31.2 days. 104 (75.2%) experienced a febrile episode, physicians considered 113 (80.1%) developed...
Frequency combs have applications that extend from the ultra-violet into mid-infrared bands. Microcombs, a miniature and often semiconductor-chip-based device, can potentially access most of these applications, but are currently more limited in spectral reach. Here, we demonstrate mode-locked silica microcombs with emission near edge visible spectrum. By using both geometrical mode-hybridization dispersion control, devices engineered for soliton generation while also maintaining optical $Q$...
Abstract Large‐scale screening of sequential drug combinations, wherein the dynamic rewiring intracellular pathways leads to promising therapeutic effects and improvements in quality life, is essential for personalized medicine ensure realistic cost time requirements less sample consumption. However, large‐scale requires expensive complicated liquid handling systems automation therefore lowers accessibility clinicians or biologists, limiting full potential combinations clinical applications...
ObjectiveMetaplastic breast carcinomas (MBC) are a rare type of cancer and generally characterized by hormone receptor human epidermal growth factor 2 (HER2) negativity. There is paucity information on prognosis according to HER2 expression for these tumors. The aim this study was compare the clinical features between triple-negative metaplastic carcinoma (TNMC) non-triple-negative (NTNMC).
Although droplet microfludics is a promising technology for handling number of liquids single type analyte, it has limitations in thousands different types analytes multiplex assay. Here, we present novel "liquid-capped encoded microcapsule", which applicable to various liquid format assays. Various drops can be graphically and arrayed without repeated dispensing processes, evaporation, the risk cross-contamination. Millions nanoliter-scale are encapsulated within microcapsules...
Abstract Mode-coupling-induced dispersion has been used to engineer microresonators for soliton generation at the edge of visible band. Here, we show that optical formed in this way is analogous Bragg solitons and, more generally, Dirac quantum field theory. This studied theoretically, and a closed-form solution derived corresponding conservative system. Both analytical numerical solutions unusual properties, such as polarization twisting asymmetrical spectra. The also study repetition rate...
Proteins secreted by skin have great potential as biomarkers for interpreting conditions. However, inconvenience in handling and bulky size of existing methods are limitations. Here, we describe a thumb-nail sized patch with the array microdisks which captures multiple proteins from surface. Microdisks antibody on surface enable multiplexed immunoassay. By self-assembly, placed into 2-dimensional arrays adhesive tape. The proposed Enzyme-Linked Immunospot Patch shows sufficient sensitivity...
Objective: The effectiveness of capecitabine, an oral fluoropyrimidine carbamate, is well documented in previously untreated metastatic colorectal cancer patients (overall response rate: 25%). However, its efficacy with refractory to 5-fluorouracil/leucovorin (5-FU/LV) has not been determined. This study was performed evaluate the and identify side-effects capecitabine showing progression despite 5-FU/LV-based combination chemotherapy. Methods: Fifty-one who showed progressive disease...
Neurotrophic tyrosine receptor kinase ( NTRK ) gene fusions are oncogenic drivers in various tumour types. Larotrectinib is a first-in-class, highly selective tropomyosin (TRK) inhibitor approved for use adult and paediatric patients with TRK fusion cancer, demonstrating an objective response rate (ORR) of 41% across 18 gastrointestinal (GI) cancer (Boni et al, WCGI 2021). We report updated analysis from expanded dataset GI longer follow-up. Patients treated larotrectinib the phase II...
Microparticle-based drug delivery is a promising technology for small volume bioassay platforms. The general utilization of the drug-loaded microparticles in vitro platforms requires loading method, which should impregnate types (e.g., water insoluble) with high payload into variously designed microparticles. Loading prefabricated using solvent evaporation satisfies requirement. However, similar to "coffee-ring effect," drugs are loaded seriously nonuniform manner, caused by capillary flow...
Understanding tissue engineering using a bottom-up approach has been hindered by technical limitations because no platform can demonstrate the controlled formation of heterogeneous population cells in microscale. Here, we hierarchical shape-by-shape assembly virus-laden particles into larger ones to transfect two different genes on seeded cells. We show that smaller daughter with sizes and shapes be assembled matching indentations parent shapes. Then, transfected gene-transfecting viruses,...
We propose a method of forming quantum-size emitters within pre-defined photonic crystal in self-aligned fashion through controlled removal quantum well layers via selective wet-chemical etching. To demonstrate the effectiveness our method, we take example two-dimensional slab containing multiple wells at its center. successfully fabricate vertically stacked nanostructures (or dots) aligned with respect to backbone. Micro-photoluminescence measurements performed 78 K reveal that radiative...
We introduce an architecture for optical-frequency synthesis using photonic-chip frequency combs and a heterogeneously integrated CW laser. The Kerr dual-comb that we describe offers microwave-optical link to discipline the laser RF clock.