A5062670955- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Advanced Biosensing Techniques and Applications
- Advanced Materials and Mechanics
- Biosensors and Analytical Detection
- Modular Robots and Swarm Intelligence
- Advanced biosensing and bioanalysis techniques
- Nanofabrication and Lithography Techniques
- Micro and Nano Robotics
- Autism Spectrum Disorder Research
- Photochromic and Fluorescence Chemistry
- Cell Image Analysis Techniques
- Bacterial Identification and Susceptibility Testing
- Nanomaterials and Printing Technologies
- Genetics and Neurodevelopmental Disorders
- Field-Flow Fractionation Techniques
- Respiratory viral infections research
- Child Development and Digital Technology
- Influenza Virus Research Studies
- Advanced Sensor and Energy Harvesting Materials
- COVID-19 and healthcare impacts
- Conducting polymers and applications
- TiO2 Photocatalysis and Solar Cells
Seoul National University
2015-2024
Ministry of Health and Welfare
2021
Kyung Hee University
2018
Seoul National University Hospital
2018
University of Illinois Urbana-Champaign
2018
Government of the Republic of Korea
2017
Chungbuk National University
2015
Abstract We introduce highly programmable microscale swimmers driven by the Marangoni effect (Marangoni microswimmers) that can self-propel on surface of water. Previous studies have shown advantage self-propulsion without external energy source or mechanical systems, taking direct conversion from power materials to energy. However, current developments microswimmers limitations in their fabrication, thereby hindering programmability and precise mass production. By introducing a...
Technology for transforming a 2D pen drawing into designed 3D structure enables highly accessible, rapid fabrication.
Abstract Large‐scale screening of sequential drug combinations, wherein the dynamic rewiring intracellular pathways leads to promising therapeutic effects and improvements in quality life, is essential for personalized medicine ensure realistic cost time requirements less sample consumption. However, large‐scale requires expensive complicated liquid handling systems automation therefore lowers accessibility clinicians or biologists, limiting full potential combinations clinical applications...
Although droplet microfludics is a promising technology for handling number of liquids single type analyte, it has limitations in thousands different types analytes multiplex assay. Here, we present novel "liquid-capped encoded microcapsule", which applicable to various liquid format assays. Various drops can be graphically and arrayed without repeated dispensing processes, evaporation, the risk cross-contamination. Millions nanoliter-scale are encapsulated within microcapsules...
Physical unclonable functions (PUFs) enable different characteristics according to the purpose, such as easy access identification, high security level, and code capacity, against counterfeiting a product. However, most multiplex approaches have been implemented by embedding several features rather than one feature. In this paper, we present level anti-counterfeiting strategy using only labyrinth wrinkle patterns with complexities, which can be used unique codes. To generate codes levels in...
"Intelligent" polymer nanocomposites have been an intensely popular research topic for several decades. These materials are based on combinations of two technologies: 1) the bottom-up synthesis nanoparticles to assign a novel functionality and 2) top-down photolithography polymers create desirable microstructures. Such intelligent comprised functional embedded in mesh, these enable display functions properties that natural cannot possibly show. Herein, we introduce categorize according their...
Liquid biopsy holds promise towards practical implementation of personalized theranostics cancer. In particular, circulating tumour cells (CTCs) can provide clinically actionable information that be directly linked to prognosis or therapy decisions. this study, gene expression patterns and genetic mutations in single CTCs are simultaneously analysed by strategically combining microfluidic technology situ molecular profiling technique. Towards this, the development demonstration OPENchip...
Proteins secreted by skin have great potential as biomarkers for interpreting conditions. However, inconvenience in handling and bulky size of existing methods are limitations. Here, we describe a thumb-nail sized patch with the array microdisks which captures multiple proteins from surface. Microdisks antibody on surface enable multiplexed immunoassay. By self-assembly, placed into 2-dimensional arrays adhesive tape. The proposed Enzyme-Linked Immunospot Patch shows sufficient sensitivity...
Multiplexed, scanner-based colorimetric detection of autoantibodies in plasma was achieved using graphically encoded particles and gold nanoparticles.
Microparticle-based drug delivery is a promising technology for small volume bioassay platforms. The general utilization of the drug-loaded microparticles in vitro platforms requires loading method, which should impregnate types (e.g., water insoluble) with high payload into variously designed microparticles. Loading prefabricated using solvent evaporation satisfies requirement. However, similar to "coffee-ring effect," drugs are loaded seriously nonuniform manner, caused by capillary flow...
Understanding tissue engineering using a bottom-up approach has been hindered by technical limitations because no platform can demonstrate the controlled formation of heterogeneous population cells in microscale. Here, we hierarchical shape-by-shape assembly virus-laden particles into larger ones to transfect two different genes on seeded cells. We show that smaller daughter with sizes and shapes be assembled matching indentations parent shapes. Then, transfected gene-transfecting viruses,...
An outbreak of COVID-19 with an extremely high attack rate happened in a psychiatric closed ward. One hundred two (98.1%) out 104 patients were diagnosed between February 20th and 26th, 2020, most whom schizophrenia. Facility factors (such as multi-share rooms, windows, absence alcohol hand rubs), along chronic medical conditions, difficulty to explain symptoms for might have contributed the rate. To overcome these hurdles, efficient ventilating filtration system facilities, strict access...
Since the discovery of antibiotics, emergence antibiotic resistance has become a global issue that is threatening society. In era resistance, finding proper antibiotics through susceptibility testing (AST) crucial in clinical settings. However, current process AST based on broth microdilution test limitations scalability to expand number are tested with various concentrations. Here, we used color-coded droplets multiplexing regarding kind and concentration antibiotics. Color type density...
Encoded microparticles have great potential in small-volume multiplexed assays. It is important to link the micro-level assays macro-level by indexing and manipulating enhance their versatility. There are technologies actively manipulate encoded microparticles, but none capable of directly with homogeneous physical properties. Here, we report image-based laser-induced forward transfer system for active manipulation graphically microparticles. By demonstrating direct retrieval interest, show...
The need for high-throughput screening has led to the miniaturization of reaction volume chamber in bioassays. As reactor gets smaller, surface tension dominates gravitational or inertial force, and mixing efficiency decreases small-scale reactions. Because passive by simple diffusion tens microliter-scale volumes takes a long time, active is needed. Here, we report an efficient micromixing method using magnetically rotating microparticles with patterned magnetization induced magnetic...
This manuscript presents a comprehensive study on the assembly of microchips using fluidic self-assembly (FSA) technology, with focus optimizing spacing between binding sites to improve yield and assembly. Through series experiments, we explored substrates varying site spacings, revealing impact rate undesired chip across multiple sites. Our findings indicate significant reduction in incorrect rates as increases beyond critical threshold 140 μm. delves into mechanics alignment within fluid...
This study presents an innovative solution for the enhanced tracking and security of pharmaceuticals through development microstructures incorporating environmentally responsive, coded microparticles. Utilizing maskless photolithography, we engineered these microparticles with a degradable masking layer 30 μm thickness that undergoes controlled dissolution. Quantitative analysis revealed protective layer's degradation, monitored by red fluorescence intensity, diminishes predictably over 144...
So far, most research studying the causality of autism has focused on neurobiological or psychological aspects. However, studies have dealt with only proximal autism, and there is little its ultimate causality. 'Evolutionary perspective', which received attention recently in various academic fields, suggests several theories regarding autism. We reviewed different evolution discussed both merits limitations theories.
In article number 1600427, Sunghoon Kwon and co-workers describe how to load drug vehicles by freezedrying. The dissolved molecules are loaded into adjacent prefabricated microparticles as the solvent dries out. This approach prevents capillary-flow-driven non-uniform loading, which is similar what known “coffee-ring effect”. delivered amount of can be controlled precisely, regardless particle type.
The need for a robotic pipetting machine to manage several substances limits the accessibility of high-throughput screening techniques general researchers. In article number 1801380, Jiyun Kim, Sunghoon Kwon, and co-workers report method generate large-scale heterogeneous drug-releasing-microarray via “pipetting-free” manner by self-assembly encoded drug-laden microparticles on array microwells.