A5101675467- Dementia and Cognitive Impairment Research
- Organic Electronics and Photovoltaics
- Organic Light-Emitting Diodes Research
- Luminescence and Fluorescent Materials
- Alzheimer's disease research and treatments
- Hormonal and reproductive studies
- Dermatological and COVID-19 studies
- Magnetic and Electromagnetic Effects
- Nuclear and radioactivity studies
- Cholinesterase and Neurodegenerative Diseases
- Ocular Diseases and Behçet’s Syndrome
- Herpesvirus Infections and Treatments
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Pain Mechanisms and Treatments
- Schizophrenia research and treatment
- Risk and Safety Analysis
- Pancreatic function and diabetes
- Acute Ischemic Stroke Management
- Traditional Chinese Medicine Studies
- Neuropeptides and Animal Physiology
- Stroke Rehabilitation and Recovery
- Autophagy in Disease and Therapy
Sungkyunkwan University
2022-2024
Dong-A University
2023
Gachon University Gil Medical Center
2018
Chonnam National University Hospital
2013
University of California, Los Angeles
2009
Promotion of mitophagy is considered a promising strategy for the treatment neurodegenerative diseases including Alzheimer's disease (AD). The development mitophagy-specific inducers with low toxicity and defined molecular mechanisms essential clinical application mitophagy-based therapy. aim this study was to investigate potential novel small-molecule inducer, ALT001, as AD.
In designing thermally activated delayed fluorescence (TADF) emitters, a high reverse intersystem crossing (RISC) rate with photoluminescence quantum yield is essential. Herein, two blue TADF molecules, 2′,5′-di(9H-carbazol-9-yl)-3′,6′-bis(3,6-ditert-butyl-9H-carbazol-9-yl)-[1,1′:4′,1″-terphenyl]-4,4″-dicarbonitrile (CzTCzPhBN) and 2′,5′-bis(3,6-ditert-butyl-9H-carbazol-9-yl)-3′,6′-bis(3,6-diphenyl-9H-carbazol-9-yl)-[1,1′:4′,1″-terphenyl]-4,4″-dicarbonitrile (PhCzTCzPhBN) RISC rate, were...
Behavioral variant frontotemporal dementia (bvFTD) is a subtype of dementia, which has clinical symptoms progressive personality and behavioral changes with deterioration social cognition executive functions. The pathology bvFTD known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, were recently developed tau PET, in patients clinically-diagnosed bvFTD.Forty-eight participants, including participants (bvFTD, n=3), Alzheimer's disease...
The objective of this study was to investigate topographical distribution and relationships tau β-amyloid pathology in the early-onset (EOAD) late-onset Alzheimer disease (LOAD) with APOE ε4 allele (EOAD ε4+ LOAD ε4+) without ε4- ε4-). We included a total number 165 participants including 25 patients EOAD ε4+, 29 ε4-, 24 21 33 young old cognitively normal participants. All completed 18F-THK5351(THK) 18F-flutemetamol (FMM) PET scans, 3T MRI, genotyping detailed neuropsychological tests....