A5080848606- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Drug Transport and Resistance Mechanisms
- Cognitive Abilities and Testing
- Language Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Inflammation biomarkers and pathways
- Neurobiology of Language and Bilingualism
- Cognitive Functions and Memory
- Neurological Disease Mechanisms and Treatments
- Medical Imaging Techniques and Applications
Gachon University
2018-2024
The objectives of this study were to compare the topographical subcortical shape and investigate effects tau or amyloid burden on atrophic patterns in early onset Alzheimer's disease (EOAD) late-onset (LOAD). One hundred sixty-one participants (53 EOAD, 44 LOAD, 33 young controls, 31 older controls) underwent [18F]THK5351 positron emission tomography (PET), [18F]flutemetamol (FLUTE) PET, 3T MRI scans. We used surface-based analysis evaluate structural shape, permutation-based statistics for...
The expression of the 18-kDA mitochondrial translocator protein (TSPO) in brain is an attractive target to study neuroinflammation. However, binding properties TSPO ligands are reportedly dependent on genetic polymorphism gene (rs6971). objective this investigate rs6971 Korean population.We performed testing 109 subjects including patients with mild cognitive impairment, Alzheimer's disease (AD) dementia, non-AD and cognitively unimpaired participants. Magnetic resonance imaging scans...
The objectives of this study were to investigate the variable factors associated with cognitive function and cortical atrophy estimated importance those in affecting patients EOAD LOAD. Patients (n = 40), LOAD 34), healthy volunteers normal cognition included 65). All them performed 3T MRI, [18F]THK5351 PET (THK), [18F]flutemetamol (FLUTE), detailed neuropsychological tests. To test results thickness each group, we conducted multivariable linear regression models, including amyloid, tau,...
Behavioral variant frontotemporal dementia (bvFTD) is a subtype of dementia, which has clinical symptoms progressive personality and behavioral changes with deterioration social cognition executive functions. The pathology bvFTD known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, were recently developed tau PET, in patients clinically-diagnosed bvFTD.Forty-eight participants, including participants (bvFTD, n=3), Alzheimer's disease...
Background and Purpose There are three distinct subtypes of primary progressive aphasia (PPA): the nonfluent/agrammatic variant (nfvPPA), semantic (svPPA), logopenic (lvPPA).We sought to characterize pattern [ 18 F]-THK5351 retention across all determine topography correlated with each neurolinguistic score.Methods We enrolled 50 participants, comprising 13 PPA patients (3 nfvPPA, 5 svPPA, lvPPA) 37 subjects normal cognition (NC) who underwent 3.0-tesla magnetic resonance imaging,...
Alzheimer's disease (AD) does not always mean amyloid positivity. [18F]THK-5351 has been shown to be able detect reactive astrogliosis as well tau accompanied by neurodegenerative changes. We evaluated the retention patterns in positron-emission tomography (PET) and clinical characteristics of patients clinically diagnosed with AD dementia who had negative PET findings.We performed 3.0-T magnetic resonance imaging, PET, 164 dementia. Amyloid was visually scored positive or negative. were...
Abstract Background Computerized cognitive training (CCT) has been proposed as a potential therapy for decline. One of the benefits CCT is transfer effect, but its mechanism on memory domain unclear. This study aimed to investigate effect non‐memory multidomain and neural basis in patients with mild impairment (MCI) through randomized controlled trial. Methods Patients MCI recruited from clinics were randomly assigned either or control group. The group received excluding training, while read...
Abstract Background Cognitive intervention is accepted as a potential therapy to prevent the incident dementia. It was found that computerized cognitive training might be effective for older adults with mild impairment (MCI) in previous studies. We aimed find effect of multidomain using tablet computer on and psychological function patients MCI. Method Participants group (n = 15) conducted program table those control 13) an educational book reading twice week eight weeks. They were evaluated...
Little is known regarding the differential effects of apolipoprotein E (APOE) ɛ4 on regional topography amyloid and tau in patients with both early-onset (EOAD) late-onset Alzheimer's disease (LOAD).To compare distribution association tau, amyloid, cortical thickness among groups classified by presence APOEɛ4 allele onset age.A total 165 participants including 54 EOAD (29 ɛ4-; 25 ɛ4+), 45 LOAD (21 24 66 age-matched controls underwent 3T MRI, 18F-THK5351 (THK) 18F-flutemetamol (FLUTE) PET...