A5024670178- Synthetic Organic Chemistry Methods
- Bacteriophages and microbial interactions
- Hearing, Cochlea, Tinnitus, Genetics
- RNA regulation and disease
- Plant Molecular Biology Research
- Coenzyme Q10 studies and effects
- Organophosphorus compounds synthesis
- Alzheimer's disease research and treatments
- Synthesis and biological activity
- HIV Research and Treatment
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Viral-associated cancers and disorders
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Synthesis and Characterization of Pyrroles
- Quinazolinone synthesis and applications
- Electron Spin Resonance Studies
- Adenosine and Purinergic Signaling
- Cancer Treatment and Pharmacology
- Autophagy in Disease and Therapy
- Cholinesterase and Neurodegenerative Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
Dong-A University
2021-2025
Rationale: One of the hallmarks Alzheimer's disease (AD) is accumulation dysfunctional mitochondria. Herpes simplex virus type 1 (HSV1) may be a risk factor for neuropathology linked to amyloid β (Aβ) accumulation. However, mechanisms underlying HSV1-associated mitochondrial dysfunction in AD remain unclear. ALT001 novel drug that ameliorates AD-related cognitive impairment via ULK1/Rab9-mediated alternative mitophagy. In this study, we investigated effects on neurodegeneration-related...
Cisplatin-induced ototoxicity leads to hearing impairment, possibly through reactive oxygen species (ROS) production and DNA damage in cochlear hair cells (HC), although the exact mechanism is unknown. Avenanthramide-C (AVN-C), a natural, potent antioxidant, was evaluated three study groups of normal adult C57Bl/6 mice (control, cisplatin, AVN-C+cisplatin) for prevention cisplatin-induced loss. Auditory brainstem responses immunohistochemistry outer (OHCs) were ascertained. Cell survival,...
Promotion of mitophagy is considered a promising strategy for the treatment neurodegenerative diseases including Alzheimer's disease (AD). The development mitophagy-specific inducers with low toxicity and defined molecular mechanisms essential clinical application mitophagy-based therapy. aim this study was to investigate potential novel small-molecule inducer, ALT001, as AD.
Drug repurposing approach was applied to find a potent antiviral agent against RNA viruses such as SARS-CoV-2, influenza and dengue virus with concise strategy of small change in parent molecular structure. For this purpose, β-D-N4-hydroxycytidine (NHC, 1) broad spectrum activity chosen the molecule. Among prepared NHC analogs (8a-g, 9) from uridine, β-D-N4-O-isobutyrylcytidine (8a) showed SARS-CoV-2 (EC50 3.50 μM), Flu A (H1N1) 5.80 (H3N2) 7.30 B 3.40 μM) DENV-2 3.95 vitro. Furthermore, its...
A direct synthetic strategy of aryloxy phosphonamidate nucleotide prodrugs (A, G, C, and U) was developed with the CM reaction assisted by ultrasonic irradiation partitioned addition 12 mol % Hoveyda–Grubbs (H-G) II catalyst in 61–82% yields as a mixture E-/Z-isomers (∼2:1) from vinylphosponamidate 5′-vinyl nucleoside moieties.
Esterification of idebenone with commercially available straight‐chain aliphatic acids, branched‐chain aromatic or nonsteroidal anti‐inflammatory drugs afforded their corresponding idebenonyl esters ( 5a – k ) in good yield. The values cell viability for RC‐58T at 50 μM were 86.3% , 75.9% 5b 23.4% 5d 61.2% 5f 67.9% 5h 70.6% 5i and 49.0% 5j .
3-Deazaneplanosin A (DZNep, 2) analogs showed a broad spectrum of biological activity against some cancers and DNA/RNA viruses as promising inhibitor the S-adenosyl-L-homocysteine (SAH) hydrolase enhancer zeste homolog 2 (EZH2). Recently, 3-halogenated DZNep were reported potent inhibitors RNA an SAH hydrolase, but 6-halogenated its was not studied antiviral agent to date. Thus, N9-/N7-2,6-dihalo-DZNep N7-6-amino/azido-DZNep prepared using Mitsunobu reaction 3-deazapurine derivatives with...