A5054217271- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Ear and Head Tumors
- Facial Nerve Paralysis Treatment and Research
- Tracheal and airway disorders
- Reconstructive Facial Surgery Techniques
- Cancer-related molecular mechanisms research
- Nerve injury and regeneration
- Speech and Audio Processing
- Neurogenesis and neuroplasticity mechanisms
- Noise Effects and Management
- Nasal Surgery and Airway Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Congenital Ear and Nasal Anomalies
- Head and Neck Surgical Oncology
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Head and Neck Anomalies
- Infection Control and Ventilation
- Airway Management and Intubation Techniques
- Climate Change and Health Impacts
- Otolaryngology and Infectious Diseases
- MicroRNA in disease regulation
Chonnam National University Hospital
2016-2025
Chonnam National University
2011-2025
Changwon National University
2023
Gyeongsang National University
2023
Creative Commons
2020
Chonnam National University Hwasun Hospital
2020
National Research Foundation of Korea
2020
Weatherford College
2020
Family Research Institute
2015
Abstract Background Adult mesenchymal stem cells (MSCs) derived from adipose tissue have the capacity to differentiate into as well endodermal and ectodermal cell lineage in vitro . We characterized multipotent ability of human tissue-derived (hADSCs) MSCs investigated neural differentiation potential these cells. Results Human ADSCs earlobe fat maintained self-renewing differentiated adipocytes, osteoblasts, or chondrocytes under specific culture conditions. Following induction with bFGF...
Abstract Objectives/Hypothesis: The purpose of this study was to investigate the effects platelet‐rich plasma (PRP) and neural‐induced human mesenchymal stem cells (nMSCs) on axonal regeneration from a facial nerve axotomy injury in guinea pig model. Study Design: Prospective, controlled animal study. Methods: Experiments involved transection repair 24 albino pigs. Four groups were created based method repair: suture only (group I, control group); PRP with II); nMSCs III); IV). Each applied...
While microRNAs have emerged as an important component of gene regulatory networks, it remains unclear how collaborate with transcription factors in the networks that determines neuronal cell fate. Here we show developing spinal cord, expression miR-218 is directly upregulated by Isl1–Lhx3 complex, which drives motor neuron Inhibition suppresses generation neurons both chick neural tube and mouse embryonic stem cells, suggesting plays a crucial role differentiation. Results from unbiased...
Alport syndrome (AS) is a genetic disorder marked by mutations in type IV collagen, leading to kidney glomerular dysfunction. AS also involves the cochlea, causing late-onset progressive hearing loss. Currently, there are no therapeutic drugs protect from AS. HDAC inhibitors (HDACis) chemical compounds that block activity of histone deacetylase and known exert diverse biologic effects. We investigated effect Trichostatin A (TSA), an HDACi, assess its potential inhibit deterioration Col4a3...
The aim of this study was to determine the effects transplanted neural differentiated human mesenchymal stem cells (hMSCs) in a guinea pig model auditory neuropathy. In study, hMSCs were pretreated with neural-induction protocol and into scala tympani cochlea 7 days after ouabain injury. A control made by injection Hanks balanced salt solution alone We established neuropathy using 1 mM application round window niche. After niche, degeneration most spiral ganglion neurons (SGNs) without loss...
To evaluate the usefulness of silicone blocks as graft material for mastoid cavity obliteration in prevention problematic cavities after canal wall down mastoidectomies.Retrospective evaluation 20 patients who underwent with between 2002 and 2009 at Chonnam National University Hospital. The cases consisted 17 chronic otitis media cholesteatoma 3 adhesive media. postoperative follow-up period was an average 49 months (range, 6 to 90 months). surgical technique used our institution composed...
Cisplatin-induced ototoxicity leads to hearing impairment, possibly through reactive oxygen species (ROS) production and DNA damage in cochlear hair cells (HC), although the exact mechanism is unknown. Avenanthramide-C (AVN-C), a natural, potent antioxidant, was evaluated three study groups of normal adult C57Bl/6 mice (control, cisplatin, AVN-C+cisplatin) for prevention cisplatin-induced loss. Auditory brainstem responses immunohistochemistry outer (OHCs) were ascertained. Cell survival,...
Mesenchymal stem cells (MSCs) have therapeutic effects on neurodegenerative diseases (NDDs) known by their secreted molecules, referred to as the "secretome". The mitochondrial complex I inhibitor, rotenone (ROT), reproduces α-synuclein (α-syn) aggregation seen in Parkinson's disease (PD). In this present study, we examined neuroprotective of secretome from neural-induced human adipose tissue-derived (NI-ADSC-SM) during ROT toxicity SH-SY5Y cells. Exposure significantly impaired mitophagy...
In mammals, cochlear hair cell loss is irreversible and may result in a permanent sensorineural hearing loss. Secondary to this loss, progressive of spiral ganglion neurons (SGNs) presented. study, we have investigated the effects neural-induced human mesenchymal stem cells (NI-hMSCs) from bone marrow on sensory neuronal regeneration neomycin treated deafened guinea pig cochleae.HMSCs were isolated which was obtained mastoid process during mastoidectomy for ear surgery. Following neural...
Rotenone (ROT) inhibits mitochondrial complex I, leading to reactive oxygen species formation, which causes neurodegeneration and alpha-synuclein (α-syn) aggregation and, consequently, Parkinson's disease. We previously found that a neurogenic differentiated human adipose tissue-derived stem cell-conditioned medium (NI-hADSC-CM) was protective against ROT-induced toxicity in SH-SY5Y cells. In the present study, ROT significantly decreased phospho (p)-mTORC1/total (t)-mTOR, p-mTORC2/t-mTOR,...
Transcanal endoscopic ear surgery (TEES) provides minimally invasive transcanal access to the middle and improves visibility during cholesteatoma resection. However, literature on outcomes following TEES alone for removal of congenital (CC) is lacking limited small series.
Abstract Noise exposure or ototoxic drugs instigate various types of damage to the cochlea, resulting in hearing loss (HL). While incidence HL is growing continuously, there are, so far, no adequate prevent treat HL. Avenanthramide (AVN), a natural product extracted from oats, has been reported possess anti-oxidant/inflammatory properties, and protect several cells. In this study, we investigated whether AVN-C can auditory hair cells, preserve noise trauma drugs. Wild-type C57BL/6 mice were...
Objectives Autologous costal cartilage is a promising alternative for mastoid obliteration. However, donor-site morbidities of the chest wall limit use this graft. To address issue, we have developed minimally-invasive technique harvesting and report donor site morbidity associated with procedure. Methods Donor were evaluated 151 patients who underwent harvest, canal down mastoidectomy, Pain cosmetic concern via visual analogue scale (VAS). Scars modified Vancouver Scar Scale (VSS) Patient...
While a severe to profound sudden sensorineural hearing loss (SSNHL) may cause serious disability in verbal communication, there have been little studies focusing on this high degree SSNHL. The present study was aimed investigate the characteristics of recovery SSNHL (>70 dB).Three hundred and two patients were enrolled. For long-term follow-up, 46 evaluated. Hearing level examined by pure tone audiometry day 1, week 3, month 6, year 1 or after. According initial loss, divided into 4 groups...
Abstract Objective To investigate the safety and efficacy of a novel active transcutaneous bone conduction implant (BCI) device for patients with single‐sided deafness (SSD). Study Design Prospective cohort study. Setting Tertiary referral hospitals. Methods This prospective multicenter study was conducted at 15 institutions nationwide. Thirty adult (aged ≥19 years) SSD were recruited. They underwent implantation an BCI (Bonebridge BCI602). outcomes included aided pure‐tone thresholds,...
Superficial siderosis (SS) of the CNS is associated with cerebellar ataxia, sensorineural hearing loss, and pyramidal symptoms, which result from iron depositions on surfaces. SS can produce bilateral vestibulopathy as vestibulo-cochlear nerve particularly vulnerable. To our knowledge, however, vestibular dysfunction in has not been reported thoroughly literature. Here, we describe a case vestibulopathy, documented quantitatively by video head impulse test (vHIT), patient SS.A 60-year-old...
The purpose of this study was to identify delayed auditory maturation and the fate premature infants who failed newborn hearing screening (NHS) in neonatal intensive care unit.A total 1375 neonates underwent NHS using transient evoked otoacoustic emission (TEOAE) a tertiary hospital between 2007 2010 according Joint Committee on Infant Hearing guidelines. In addition, structured telephone survey given caregivers were lost follow-up NHS. Auditory steady-state response (ASSR) threshold change...
Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing in mammals. Stem cells have been confirmed be able differentiate into neurons. Little has reported on adipose tissue-derived stem (ADSCs) for repair injured In this study, we hypothesized that transplantation neural induced-human ADSCs (NI-hADSCs) the neurons guinea pigs with neomycin-induced loss. NI-hADSCs were induced culture...
Objective: Otitis media (OM) is an infectious and inflammatory disease of the middle ear (ME) that often recurs requires long-term antibiotic treatment. Light emitting diode (LED)-based devices have shown therapeutic efficacy in reducing inflammation. This study aimed to investigate anti-inflammatory effects red near-infrared (NIR) LED irradiation on lipopolysaccharide (LPS)-induced OM rats, human epithelial cells (HMEECs), murine macrophage (RAW 264.7). Methods: An animal model was...
We evaluated the accuracy, positive predictive value (PPV), negative (NPV), specificity and sensitivity of eight anatomic landmarks to differentiate parotid deep lobe tumours from superficial tumours: lateral margin retromandibular vein (RMV), a straight line facial nerve trunk (FN trunk) mandibular ramus line), FN RMV (tRMV), masseter (tMasseter), ipsilateral vertebral posterior end (U-line), an arc with radius 8.5 mm centred on (Conn's arc), surface muscle (rMasseter) angle line, tumour...
Objectives. To evaluate the results of transcanal endoscopic tympanoplasty for pediatric patients with chronic otitis media (COM) and compare them to that previously standard microscopic assisted technique.Methods. The were divided into two groups based on operative method. Group 1 underwent a totally technique (n=21, 24 ears), group 2 conventional (n=14, 15 ears). We used approach in postauricular 2. In 1, there cases simple COM nine adhesive media. 2, only present. analyzed outcomes terms...