A5046555120- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Cerebral Venous Sinus Thrombosis
- Ear and Head Tumors
- Neural dynamics and brain function
- Nuclear Receptors and Signaling
- Glaucoma and retinal disorders
- RNA regulation and disease
- Facial Nerve Paralysis Treatment and Research
- Vascular Malformations Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Meningioma and schwannoma management
- Multisensory perception and integration
- Ophthalmology and Eye Disorders
- Neuroscience and Music Perception
- RNA Interference and Gene Delivery
- Hearing Impairment and Communication
- Neuroinflammation and Neurodegeneration Mechanisms
- Nasal Surgery and Airway Studies
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Vascular Malformations and Hemangiomas
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2011-2024
Seoul National University Hospital
2007-2024
Hanyang University
2015-2023
National University College
2009-2023
New Generation University College
2009-2023
Johns Hopkins University
2021-2022
Johns Hopkins Medicine
2021-2022
Hanyang University Medical Center
2015-2021
Korea University Medical Center
2020
Thalamocortical dysrhythmia (TCD) is a model proposed to explain divergent neurological disorders. It characterized by common oscillatory pattern in which resting-state alpha activity replaced cross-frequency coupling of low- and high-frequency oscillations. We undertook data-driven approach using support vector machine learning for analyzing electroencephalography patterns patients with Parkinson's disease, neuropathic pain, tinnitus, depression. show spectrally equivalent but spatially...
Abstract Alzheimer’s disease (AD) is the most common cause of age-related dementia. Increasing evidence suggests that neuroinflammation mediated by microglia and astrocytes contributes to progression severity in AD other neurodegenerative disorders. During progression, resident undergo proinflammatory activation, resulting an increased capacity convert resting reactive astrocytes. Therefore, are a major therapeutic target for blocking microglia-astrocyte activation could limit...
Article1 March 2021Open Access Transparent process SGK1 inhibition in glia ameliorates pathologies and symptoms Parkinson disease animal models Oh-Chan Kwon orcid.org/0000-0002-6433-4507 Department of Biochemistry Molecular Biology, College Medicine, Hanyang University, Seoul, Korea Biomedical Research Institute, Graduate School Science Engineering, SeoulThese authors contributed equally to this work Search for more papers by author Jae-Jin Song KoreaThese Yunseon Yang Seong-Hoon Kim Seoul...
We present diagnostic criteria for mal de débarquement syndrome (MdDS) inclusion into the International Classification of Vestibular Disorders. The include following: 1] Non-spinning vertigo characterized by an oscillatory perception (‘rocking,’ ‘bobbing,’ or ‘swaying’) continuously most day; 2] Onset occurs within 48 hours after end exposure to passive motion, 3] Symptoms temporarily reduce with motion (e.g. driving), and 4] persist >48 hours. MdDS may be designated as “in evolution,” if...
Abstract Use of the physiological mechanisms promoting midbrain DA ( mDA ) neuron survival seems an appropriate option for developing treatments Parkinson's disease PD ). neurons are specifically marked by expression transcription factors Nurr1 and Foxa2. We show herein that Foxa2 interact to protect against various toxic insults, but their is lost during aging degenerative processes. In addition proposed cell‐autonomous actions in neurons, forced these neighboring glia synergistically...
Background Peripheral auditory deafferentation and central compensation have been regarded as the main culprits of tinnitus generation. However, patient-to-patient discrepancy in range percentage daytime which is perceived (tinnitus awareness percentage, 0 – 100%), not fully explicable only by peripheral deafferentation, considering that a stable persisting phenomenon but intermittently most patients. Consequently, involvement dysfunctional noise cancellation mechanism has recently suggested...
Intraneuronal inclusions of misfolded α-synuclein (α-syn) and prion-like spread the pathologic α-syn contribute to progressive neuronal death in Parkinson’s disease (PD). Despite significance, no efficient therapeutic intervention targeting α-synucleinopathy has been developed. In this study, we provide evidence that astrocytes, especially those cultured from ventral midbrain (VM), show potential alleviate pathology multiple vitro vivo α-synucleinopathic models. Regulation proteostasis...
Multiple wavelength light sources in the medical spectral window region are useful for various sensing applications tissue by distinguishing absorption and scattering coefficients optically. We propose a simultaneous second harmonic generation of multiple fiber laser output using parallel channels periodically-poled lithium niobate (PPLN) waveguides. High intensity dual lasing is experimentally realized with two tunable Bragg gratings 1,547.20 nm 1,554.48 efficient conversion to half...
OBJECTIVE A dominant sigmoid sinus with focal dehiscence or thinning (DSSD/T) of the overlying bony wall is a commonly encountered, but frequently overlooked, cause vascular pulsatile tinnitus (VPT). Also, pathophysiological mechanism sound perception in patients VPT remains poorly understood. In present study, novel surgical method, termed transmastoid SS-reshaping surgery, was introduced to ameliorate DSSD/T. The authors reviewed case series, analyzed outcomes, and suggested perception....
Tinnitus is a multifactorial condition with no universally accepted assessment guidelines. The Korean Study Group previously established consensus statements on the definition, classification, and diagnostic tests for tinnitus. As continuation of this effort, study aims to establish expert tinnitus treatment outcome evaluation, specifically tailored clinical context. A modified Delphi method involving 26 otology experts from across Korea was used. two-round survey conducted evaluate related...