A5030792166- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Dysphagia Assessment and Management
- Airway Management and Intubation Techniques
- Neuroscience of respiration and sleep
- Nasal Surgery and Airway Studies
- Facial Nerve Paralysis Treatment and Research
- Allergic Rhinitis and Sensitization
- Voice and Speech Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
- Oral and Maxillofacial Pathology
- Hearing, Cochlea, Tinnitus, Genetics
- Anesthesia and Sedative Agents
- Head and Neck Anomalies
- Cleft Lip and Palate Research
- Non-Invasive Vital Sign Monitoring
- Foreign Body Medical Cases
- Olfactory and Sensory Function Studies
- Reconstructive Facial Surgery Techniques
- Teratomas and Epidermoid Cysts
Chonnam National University Hospital
2016-2025
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
Beijing Chao-Yang Hospital
2024
Capital Medical University
2024
Samsung Medical Center
2023
Circadian (United States)
2022-2023
Sungkyunkwan University
2023
Boston University
2023
Chonnam National University
2011-2022
Rationale: Obstructive sleep apnea is characterized by frequent reductions in ventilation, leading to oxygen desaturations and/or arousals. Objectives: In this study, association of hypoxic burden with incident cardiovascular disease (CVD) was examined and compared that “ventilatory burden” “arousal burden.” Finally, we assessed the extent which ventilatory burden, visceral obesity, lung function explain variations burden. Methods: Hypoxic, ventilatory, arousal burdens were measured from...
Objectives/Hypothesis Our objective was to determine whether drug‐induced sleep apnea (DISE) affects the successfulness of surgical outcome. Study Design Prospective, seven‐country, nonrandomized trial. Methods There were 326 consecutive obstructive (OSA) patients who had nose, palate, and/or tongue surgery included in study. DISE performed only one group. Results 170 group and 156 no‐DISE The mean preoperative body mass index (BMI) for 27.6 ± 4.6, whereas it 28.1 3.9 ( P = .23). systolic...
The Korean Society of Otorhinolaryngology-Head and Neck Surgery Rhinologic appointed a guideline development group (GDG) to establish clinical practice guideline, the GDG developed for nasal irrigation adult patients with chronic rhinosinusitis (CRS). focuses on knowledge gaps, variations, concerns associated irrigation. Nasal has been recommended as first-line treatment CRS in various guidelines, its effectiveness demonstrated through number studies robust evidence. However, no guidelines...
Abstract Background and objective The combination of the noradrenergic atomoxetine plus anti‐muscarinic oxybutynin acutely increased genioglossus activity reduced obstructive sleep apnoea (OSA) severity. However, has shorter half‐life than side effects that might discourage long‐term usage. Accordingly, we aimed to test fesoterodine (Ato‐Feso), a newer with extended release formulation, on OSA severity endotypes. Methods Twelve subjects underwent randomized, double‐blind, crossover trial...
Objectives/Hypothesis To investigate long‐term complications of newer reconstructive palate surgery techniques. Study Design Retrospective case‐series analysis. Methods six‐country clinical study OSA patients who had nose and surgery. Results There were 217 patients, mean age = 43.9 ± 12.5 years, body mass index 25.9 4.7, preoperative apnea‐hypopnea [AHI] 30.5 19.1, follow‐up 41.3 months. A total palatal procedures performed, including 50 expansion sphincter pharyngoplasties (ESP), 34...
The purpose of this study was to analyze patients with epiglottic collapse, especially their clinical characteristics related obstructive sleep apnea and phenotype labeling using drug-induced endoscopy.An age-sex matched case-control conducted compare the collapse (Epi group) without (non-Epi group). All underwent endoscopy January, 2015, March, 2019, in a tertiary hospital for suspected symptoms. Demographic factors, underlying disease, overnight polysomnography, were analyzed.There no...
Vascular leiomyoma is an uncommon benign tumor of smooth muscle origin that arises from the muscularis layer blood vessel walls. We report our experiences with clinical manifestations, pathologic characteristics, and management vascular in head neck.The records 12 patients neck 11-year period were reviewed retrospectively.The included nine men three women. The locations tumors variable, including nasal cavity, auricle, hard palate, upper lip, eyelid, supraclavicular space. All but reported...
Objectives Autologous costal cartilage is a promising alternative for mastoid obliteration. However, donor-site morbidities of the chest wall limit use this graft. To address issue, we have developed minimally-invasive technique harvesting and report donor site morbidity associated with procedure. Methods Donor were evaluated 151 patients who underwent harvest, canal down mastoidectomy, Pain cosmetic concern via visual analogue scale (VAS). Scars modified Vancouver Scar Scale (VSS) Patient...
Abstract Objective Does nasal surgery affect multilevel surgical success outcome. Methods Prospective eight country nonrandomized trial of 735 obstructive sleep apnea (OSA) patients, who had palate and/or tongue surgery, divided into two groups, with or without nose surgery. Results There were 575 patients in group, 160 no group. The mean age for group 44.6 ± 11.4, 44.2 11.8. Mean preoperative BMI 27.5 3.6, 4.1, postoperative 26.3 3.7, 27.1 3.8 ( P = .006). AHI 32.7 19.4, 34.3 25.0 .377);...
Medicinal plants and their extracts have been used as important sources for drug discovery. In particular, plant-derived natural compounds, including phytochemicals, antioxidants, vitamins, minerals, are gaining attention they promote health prevent disease. Although several in vitro methods developed to confirm the biological activities of there is still considerable room reduce time cost. To overcome these limitations, silico proposed conducting large-scale analysis, but limited terms...
The purpose of this study was to identify delayed auditory maturation and the fate premature infants who failed newborn hearing screening (NHS) in neonatal intensive care unit.A total 1375 neonates underwent NHS using transient evoked otoacoustic emission (TEOAE) a tertiary hospital between 2007 2010 according Joint Committee on Infant Hearing guidelines. In addition, structured telephone survey given caregivers were lost follow-up NHS. Auditory steady-state response (ASSR) threshold change...
Rationale: A low respiratory arousal threshold is a key endotype responsible for obstructive sleep apnea (OSA) pathogenesis. Pimavanserin an antiserotoninergic capable of suppressing CO2-mediated arousals without affecting the motor response in animal models, and thus it holds potential increasing OSA subsequently reducing severity. Objectives: We measured effect pimavanserin on (primary outcome), severity, index, other endotypes (secondary outcomes). Methods: total 18 participants were...
We evaluated the accuracy, positive predictive value (PPV), negative (NPV), specificity and sensitivity of eight anatomic landmarks to differentiate parotid deep lobe tumours from superficial tumours: lateral margin retromandibular vein (RMV), a straight line facial nerve trunk (FN trunk) mandibular ramus line), FN RMV (tRMV), masseter (tMasseter), ipsilateral vertebral posterior end (U-line), an arc with radius 8.5 mm centred on (Conn's arc), surface muscle (rMasseter) angle line, tumour...
Continuous positive airway pressure treatment aggravates obstruction in patients with epiglottis collapse.In these patients, partial epiglottectomy can resolve collapse by excision of the obstructed epiglottis.However, epiglottic usually have simultaneous obstructions on multiple levels, such as soft palate, base tongue, etc.Therefore, sleep apnea cannot be controlled merely resolving collapse.The use additional continuous after is considered essential.However, no studies yet evaluated...
Obstructive sleep apnea (OSA) is a common disorder characterized by upper airway obstruction during sleep. To reduce the morbidity of OSA, specialists have explored various methods managing condition, including manifold positive pressure (PAP) techniques and surgical procedures. Nasal can cause significant discomfort sleep, it likely that improving nasal would enhance quality life PAP compliance OSA patients. Many reliable studies offered evidence to support this assumption. However, few...
Introduction To overcome the limited readability of conventional drug induced sleep endoscopy (DISE) system which only records flexible images, we devised Multimodality DISE System (MDS). MDS encompasses monitoring systems for oxygen saturation, electrocardiogram, blood pressure, snoring intensity, and patient's position. It enabled to record comprehensive situation patients who underwent DISE. In this study, compared efficacy with that system. Methods materials Ten at a tertiary hospital....