Summary Recent studies of auxin response have focused on the functions three sets proteins: (Aux) factors (ARFs), Aux/IAAs, and F‐box protein TIR1. The ARF proteins bind DNA directly activate or repress transcription target genes while Aux/IAA function. TIR1 is part a ubiquitin ligase required for degradation proteins. Here we report isolation characterization novel mutant Arabidopsis called axr5‐1 . Mutant plants are resistant to display variety auxin‐related growth defects including in...

The Notch pathway stabilizes sprouting angiogenesis by favoring stalk cells over tip at the vascular front. Because and have different properties in morphology function, their transcriptional regulation remains to be distinguished. Transcription factor Sox17 is specifically expressed endothelial cells, but its expression role front remain largely unknown.To specify of relationship with angiogenesis.Endothelial-specific deletion reduces mouse embryonic postnatal development, whereas...

Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1, but date this approach has yielded low and variable efficiency production. Gfi1 is a important for development survival. We evaluated combinatorial effects Atoh1 on using gene transfer methods neonatal explants, vivo mice. Adenoviral cultured...

Endan Li1,#, Jiwoo Choi, Hye-Ri Sim, Jiyeon Kim, Jae Hyun Jun, Jangbeen Kyung, Nina Ha, Semi Kim,<br />Keun Ho Ryu, Seung Soo Chung, Sook Sungsu Lee, Wongi Seol & Jihwan Song. BMB Reports 2023;56:178-83. https://doi.org/10.5483/BMBRep.2022-0157

Alport syndrome (AS) is a genetic disorder marked by mutations in type IV collagen, leading to kidney glomerular dysfunction. AS also involves the cochlea, causing late-onset progressive hearing loss. Currently, there are no therapeutic drugs protect from AS. HDAC inhibitors (HDACis) chemical compounds that block activity of histone deacetylase and known exert diverse biologic effects. We investigated effect Trichostatin A (TSA), an HDACi, assess its potential inhibit deterioration Col4a3...

Volcanic ash from large eruptions in and around the Korean Peninsula poses significant risks to critical facilities. This study employs Analytic Network Process (ANP) evaluate relative importance interconnectivity of different facility sectors vulnerable volcanic impacts. The analysis focused on 12 categories grouped into three main sectors: transportation, infrastructure, public facilities.Historical damage cases were analyzed using data vHub Global Program (GVP), revealing that 53.8%...

This study aims to improve the accuracy and interpretability of flood susceptibility mapping (FSM) by integrating automated machine learning (AutoML) with explainable artificial intelligence (XAI) frameworks. Using spatial data from Seoul, South Korea, ten topographic environmental factors were selected as model inputs. Initially, Tree-based Pipeline Optimization Tool (TPOT), an evolutionary AutoML algorithm, was employed construct baseline models using Gradient Boosting (GB), Random Forest...

Hazards affect people regardless of their socioeconomic situation. This study proposes a computational method for data analysis in terms the number social vulnerability variables and samples case Merapi proximal villages. For this purpose, Self Organizing Map (SOM) is considered as an effective platform to identify sites according similarity determine most relevant characterize each cluster; while Social Vulnerability Index (SoVI) used index creation measure level vulnerability. The dataset...

Cisplatin-induced ototoxicity leads to hearing impairment, possibly through reactive oxygen species (ROS) production and DNA damage in cochlear hair cells (HC), although the exact mechanism is unknown. Avenanthramide-C (AVN-C), a natural, potent antioxidant, was evaluated three study groups of normal adult C57Bl/6 mice (control, cisplatin, AVN-C+cisplatin) for prevention cisplatin-induced loss. Auditory brainstem responses immunohistochemistry outer (OHCs) were ascertained. Cell survival,...

Abstract Inflammaging is defined as low-grade, chronic, systemic inflammation in aging, the absence of overt infection. Age-associated deterioration gastrointestinal function could be ascribed to inflammaging, although evidence yet emerge. Here we show that microvessels aging mouse intestine were progressively deprived supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, became leaky. This alteration was up-regulation...

Abstract Noise exposure or ototoxic drugs instigate various types of damage to the cochlea, resulting in hearing loss (HL). While incidence HL is growing continuously, there are, so far, no adequate prevent treat HL. Avenanthramide (AVN), a natural product extracted from oats, has been reported possess anti-oxidant/inflammatory properties, and protect several cells. In this study, we investigated whether AVN-C can auditory hair cells, preserve noise trauma drugs. Wild-type C57BL/6 mice were...

Photothermal therapy (PTT) is a promising approach for effective cancer treatment because of its non-invasive procedure, low toxicity to normal tissues, and high tumour ablation efficiency. Developing PTT agent with precise imaging capabilities an essential prerequisite PTT. In this study, we developed bifunctional near-infra-red (NIR) fluorescent conjugate consisting chitosan oligosaccharide lactate (COL) the ZW800-1 NIR fluorophore (COL-ZW). We demonstrate that easy use it theranostic...

While a severe to profound sudden sensorineural hearing loss (SSNHL) may cause serious disability in verbal communication, there have been little studies focusing on this high degree SSNHL. The present study was aimed investigate the characteristics of recovery SSNHL (>70 dB).Three hundred and two patients were enrolled. For long-term follow-up, 46 evaluated. Hearing level examined by pure tone audiometry day 1, week 3, month 6, year 1 or after. According initial loss, divided into 4 groups...

Mutations in HTRA2/Omi/PARK13 have been implicated Parkinson disease (PD). PARK13 is a neuroprotective serine protease; however, little known about how confers stress protection and which protein targets are directly affected by PARK13. We reported that Arabidopsis thaliana represents complementary PD model, here we demonstrate AtPARK13, similar to human (hPARK13), mitochondrial protease. show the expression/accumulation of AtPARK13 transcripts induced heat but not other conditions,...

Photothermal therapy (PTT) using a near-infrared (NIR) heptamethine cyanine fluorophore has emerged as an alternative strategy for targeted cancer therapy. NIR fluorophores showing high molar extinction coefficient and low fluorescence quantum yield have considerable potential applications in photothermal In this study, bifunctional sorbitol–ZW800 conjugate was used advanced concept of therapeutic agents vivo imaging owing to the tumor targetability sorbitol moiety excellent property...

Background: Since it is known that serum albumin-bound dyes can cross the blood-brain barrier (BBB) after ischemia, Evans Blue dye commonly used to assess BBB disruption because of its rapid binding albumin. In addition, indocyanine green (ICG), a clinically available dye, binds proteins could also be for assessment impairment. Unlike these near-infrared (NIR) dyes, zwitterionic NIR fluorophore (ZW800-1) shows no binding, ultralow non-specific tissue uptake, and elimination from body via...

This paper presents a fragility assessment for the cladding in steel-framed constructions built extreme wind speed regions. A methodology is developed to assess performance of sandwich wall/roof panels and openings subjected wind-induced building pressures. The majority industrial buildings Korea are construction. review after recent typhoons Maemi, Kompasu Bolaven has shown that most damage originated envelope. goal this study develop model cladding, using available resistance test data,...

The two most important tasks of icebreakers are first to secure a sailing route by breaking the thick sea ice and second sail efficiently herself for purposes exploration transportation in polar seas. resistance is priority factor at preliminary design stage; not only must their efficiency be satisfied, but propulsion system will directly affected. Therefore, performance accura-tely calculated evaluated through use model tests an tank before construction starts. In this paper, new procedure...

Objective: Otitis media (OM) is an infectious and inflammatory disease of the middle ear (ME) that often recurs requires long-term antibiotic treatment. Light emitting diode (LED)-based devices have shown therapeutic efficacy in reducing inflammation. This study aimed to investigate anti-inflammatory effects red near-infrared (NIR) LED irradiation on lipopolysaccharide (LPS)-induced OM rats, human epithelial cells (HMEECs), murine macrophage (RAW 264.7). Methods: An animal model was...