A5101681096- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Chronic Myeloid Leukemia Treatments
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Organ Transplantation Techniques and Outcomes
- Melanoma and MAPK Pathways
- Eosinophilic Disorders and Syndromes
- Genomics and Phylogenetic Studies
- Acute Myeloid Leukemia Research
- Infectious Diseases and Mycology
- Microbial Community Ecology and Physiology
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Quinazolinone synthesis and applications
- RNA and protein synthesis mechanisms
- Chronic Lymphocytic Leukemia Research
- interferon and immune responses
- Renal Transplantation Outcomes and Treatments
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Protist diversity and phylogeny
- Monoclonal and Polyclonal Antibodies Research
Toho University
2004-2025
Toho University Omori Medical Center
2022-2025
Memorial Hospital of South Bend
2025
Nagoya University Hospital
1996-2022
Tokyo University of Pharmacy and Life Sciences
2016-2017
Otsuma Women's University
2010
Nagoya Medical Center
2006-2007
National Hospital Organization
2006-2007
Nagoya University
2001-2004
Chiba Cancer Center
2003-2004
Approximately 20% of familial amyotrophic lateral sclerosis (FALS) arises from germ-line mutations in the superoxide dismutase-1 (SOD1) gene. However, molecular mechanisms underlying process have been elusive. Here, we show that a neuronal homologous to E6AP carboxyl terminus (HECT)-type ubiquitin-protein isopeptide ligase (NEDL1) physically binds translocon-associated protein-δ and also ubiquitinates mutant (but not wild-type) SOD1 proportionately disease severity caused by particular...
Abstract Purpose: A positive response to gefitinib in non–small cell lung cancer (NSCLC) has been correlated mutations epidermal growth factor receptor (EGFR) gene. Previous reports have based mainly on diagnostic screening by sequencing. However, sequencing is a time-consuming and complicated procedure, not suitable for routine clinical use. Experimental Design: We developed rapid, simple, sensitive mutation detection assays the SMart Amplification Process (SMAP) applied it analyzing EGFR...
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 214:151-159 (2001) - doi:10.3354/meps214151 Dual symbiosis in cold-seep thyasirid clam Maorithyas hadalis from hadal zone Japan Trench, western Pacific Yoshihiro Fujiwara1,*, Chiaki Kato2, Noriaki Masui2, Katsunori Fujikura1, Shigeaki Kojima3 1Marine Ecosystems Research Department, and 2Frontier Program for...
Abstract Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature in different prognostic subgroups. However, precise mechanism underlying this phenomenon remains largely unknown. To understand molecular and genetic bases neuroblastoma, we have generated its cDNA libraries identified human ortholog tubulin tyrosine ligase gene ( hTTL / Nbla0660 ) as differentially expressed at high levels favorable subset tumor. Tubulin is subjected to several types...
Insights into mechanisms of drug resistance could extend the efficacy cancer therapy. To probe in melanoma, we performed siRNA screening genes that mediate development neural crest cells, from which melanocytes are derived. Here, report identification ZIC5 as a mediator melanoma resistance. is transcriptional suppressor E-cadherin expressed highly human melanoma. enhanced cell proliferation, survival, resistance, vivo growth and metastasis. Microarray analysis revealed downstream signaling...
Sequential deletion of the carboxyl-terminal amino acids (including six direct repeating units) glucosyltransferase-I (GTF-I) enzyme Streptococcus mutans revealed differential effects on sucrase and GTF activities. Removal all but one unit resulted in a truncated with significant activity no detectable activity. These results are compatible presence two functional domains enzyme.
Identification of specific drug targets is very important for cancer therapy. We recently identified zinc finger protein the cerebellum 5 ( ZIC 5) as a factor that promotes melanoma aggressiveness by platelet‐derived growth D PDGFD ) expression. However, its roles in other types remain largely unknown. Here we determined prostate PC a) and colorectal CRC cells. Results showed was highly expressed dedifferentiated tissues, whereas little expression observed relevant normal tissues. Knockdown...
DNA regions corresponding to portions of two different pressure-regulated operons previously identified in deep-sea barophilic bacteria were separately PCR amplified from a variety microorganisms and sequenced. With the sets primers employed, amplification was particularly successful more examined. 16S rRNA sequence analysis revealed that these are all phylogenetically related belong sub-branch genus Shewanella containing only bacteria. We define this as 'Shewanella barophile branch' at...
Abstract Although imatinib mesylate has shown encouraging activity in chronic myelogenous leukemia (CML), disease progression during therapy been observed, manifested by clonal expansion of mesylate‐resistant cells. On the other hand, myelosuppression related to treatment is often managed with temporary interruption or dose reduction. We here report two CML patients who had mesylate‐sensitive blast crisis (BC) immediately after discontinuation therapy. The discontinued because neutropenia....
<背景・目的>手術関連死亡の最大原因は術中の大量出血であるが，その背景には外科的手技による止血が不可能な希釈性凝固障害という病態が存在する．したがって術中の大量出血を未然に防ぐには止血のための輸血治療が必要であり，その治療指針の確立が急務である．<方法・結果>術中の大量出血・大量輸血症例を後方視的に調査した結果，その60％強を胸部大動脈瘤手術，肝臓移植術，肝臓癌・肝門部癌切除術が占めていた．術中大量出血の背景にある止血不全の主要因は，出血量の増加にともなう凝固因子（特にフィブリノゲン）の喪失，枯渇であると考えられた．そこで上記症例の手術中に起こった低フィブリノゲン血症に対し，クリオプレシピテートおよびフィブリノゲン濃縮製剤の投与を行ったところ，速やかなフィブリノゲン値の上昇と止血の改善，および術中出血量・輸血量の顕著な減少（平均で30～40％減）を認めた．<結論>術中の出血量増加時には，フィブリノゲン値を確認した上で速やかにフィブリノゲン濃縮製剤を投与することが，大量出血・大量輸血を未然に防ぎ，手術患者の予後改善に大きく貢献するとともに，血液製剤の使用削減・有効利用につながると考えられた．
A pressure-regulated operon was cloned and sequenced from a barophilic bacterium strain DB6705. Gene expression by this promote regulated at the level of transcription elevated pressure in strain. The promoter sequence similar to ompH Photobacterium sp. SS9.
A glutamine synthetase gene (glnA) was isolated from a deep-sea piezophilic bacterium, Shewanella violacea strain DSS12. 7.5-kb SacI fragment containing the complete glnA cloned and sequenced. The found to encode protein consisting of 469 amino acid residues, showing 75.0% identity Escherichia coli. Primer extension analyses revealed two transcription initiation sites in expression each site positively regulated by pressure. Putative promoters recognized σ70 σ54 were identified region...
The impact of co-infection with other pathogenic microorganisms after initiation treatment for Mycobacterium avium complex pulmonary disease (MAC-PD) has not been clearly described. This study sought to clarify the clinical outcomes MAC antimycobacterial therapy MAC.Co-infection status was defined as detection than in at least two consecutive sputum cultures 6-24 months treatment. Chest computed tomography (CT) findings and culture results were compared between alone groups.The groups...
A 75-year-old woman was referred to our hospital because of a productive cough and an abnormal shadow on chest radiography. She diagnosed as having metastatic lung adenocarcinoma harbouring ROS proto-oncogene 1 (