A5053714359- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Quinazolinone synthesis and applications
- Actinomycetales infections and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
Toho University
2022-2025
Toho University Omori Medical Center
2022-2025
<title>Abstract</title> <bold>Background</bold>: The guideline recommends the addition of amikacin liposome inhalation suspension (ALIS) to guideline-based therapy for patients with refractory <italic>Mycobacterium avium</italic> complex pulmonary disease (MAC-PD). real-world data on treatment efficacy and safety ALIS remain insufficient. <bold>Research Question</bold>: What factors influence culture conversion during ALIS, what are best practices managing ALIS-related adverse events,...
The impact of co-infection with other pathogenic microorganisms after initiation treatment for Mycobacterium avium complex pulmonary disease (MAC-PD) has not been clearly described. This study sought to clarify the clinical outcomes MAC antimycobacterial therapy MAC.Co-infection status was defined as detection than in at least two consecutive sputum cultures 6-24 months treatment. Chest computed tomography (CT) findings and culture results were compared between alone groups.The groups...
pulmonary disease (MAC-PD) is sometimes accompanied by co-infection with other pathogenic microorganisms such as
We herein report a case of Mycobacterium interjectum pulmonary disease (M. interjectum-PD) that improved considerably after azithromycin (AZM), rifampicin (RFP), and ethambutol (EB) therapy. A 69-year-old woman, managed locally for suspected NTM-PD based on chest computed tomography (CT) findings was referred to our hospital worsening productive cough six years the initial diagnosis. High-resolution CT showed right middle left lower lobe bronchiectasis with centrilobular nodules. Bronchial...
Abstract Background Amikacin liposome inhalation suspension (ALIS) improved sputum culture conversion rate at 6 months for patients with refractory Mycobacterium avium complex pulmonary disease (MAC-PD) in an international phase 3 trial. Patient characteristics and chest high-resolution CT (HRCT) findings associated ALIS effectiveness are poorly documented. Objective This study aimed to clarify MAC-PD months, elucidating patient findings. Methods We reviewed medical records of 12 whom...
Abstract Background: The impact of co-infection with other pathogenic microorganisms after initiation treatment for pulmonary Mycobacterium avium complex (MAC) disease has not been clearly demonstrated. This study sought to clarify clinical outcomes MAC antimycobacterial therapy MAC.Methods: Co-infection status was designated as the detection than in at least two consecutive sputum cultures 6-24 months treatment. Chest computed tomography (CT) findings and culture results were compared...
Abstract Background: In Mycobacterium avium complex pulmonary disease (MAC-PD), diagnosis requires a positive culture from at least two separate expectorated sputum specimens. The optimal number of examinations remains unclear. Objective: This study sought to elucidate the diagnostic yield acid-fast bacilli in MAC-PD using 3 specimens and clarify clinical characteristics patients with diagnosed Furthermore, we investigated correlation between increased yield. Methods: We reviewed medical...