A5086551759- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- Antifungal resistance and susceptibility
- Quinazolinone synthesis and applications
- Fungal Infections and Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Infectious Diseases and Tuberculosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Sarcoidosis and Beryllium Toxicity Research
- Ultrasound in Clinical Applications
- Burkholderia infections and melioidosis
- Cancer, Stress, Anesthesia, and Immune Response
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Family and Patient Care in Intensive Care Units
- Nosocomial Infections in ICU
- Extracellular vesicles in disease
- PARP inhibition in cancer therapy
Toho University
2016-2025
Toho University Omori Medical Center
2016-2025
Respiratory Clinical Trials
2022
University Medical Center HCMC
2021
Higashihiroshima Medical Center
2021
Hirosaki University
2021
Kumamoto University Hospital
2021
Nihon University
2021
Shinshu University
2021
ABSTRACT We evaluated the usefulness of an Aspergillus galactomannan (GM) test, a β- d -glucan (βDG) and two different PCR assays bronchoalveolar lavage fluid (BALF) samples for diagnosis chronic pulmonary aspergillosis (CPA). BALF from 30 patients with 120 without CPA were collected. calculated sensitivity, specificity, positive predictive value, negative likelihood ratio, diagnostic odds ratio each test individually in combination other tests. The optical density index values, as...
Abstract Approximately one-third of fibrosing interstitial lung diseases exhibit progressive pulmonary fibrosis (PPF), a clinicopathological condition distinct yet resembling idiopathic (IPF). PPF in ANCA-positive ILD (ANCA-ILD) is poorly documented. To clarify incidence, predictors ANCA-ILD, and their prognostic impact, 56 patients with ANCA-ILD were followed for ≥ 1 year (April 2004 to April 2021). was defined per ATS/ERS/JRS/ALAT 2022 guideline. We compared non-PPF 38 function tests...
Abstract A 66‐year‐old woman was found to have abnormal shadows on a chest radiograph at previous hospital 4 years ago, which led diagnosis of lung adenocarcinoma, cT2aN1M1b stage IVA. First‐line treatment included carboplatin and paclitaxel plus thoracic radiotherapy stereotactic radiation therapy for brain metastases. The patient later underwent second‐line pemetrexed treatment, followed by third‐line nivolumab, fourth‐line docetaxel bevacizumab, fifth‐line tegafur‐gimeracil‐oteracil,...
<title>Abstract</title> <bold>Background</bold>: The guideline recommends the addition of amikacin liposome inhalation suspension (ALIS) to guideline-based therapy for patients with refractory <italic>Mycobacterium avium</italic> complex pulmonary disease (MAC-PD). real-world data on treatment efficacy and safety ALIS remain insufficient. <bold>Research Question</bold>: What factors influence culture conversion during ALIS, what are best practices managing ALIS-related adverse events,...
The distress experienced by patients during bronchoscopy is often more severe than bronchoscopists anticipate. However, the use of sedatives varies depending on facility, which may be insufficient. We examined accuracy bronchoscopist evaluation predicted patient discomfort under intravenous sedation. This study retrospectively reviewed 186 consecutive who underwent between December 2018 and April 2019. Ultimately, 113 with pethidine (meperidine) 64 midazolam were assigned to group...
Abstract In Mycobacterium avium infections, macrophages play a critical role in the host defense response. Apoptosis inhibitor of macrophage (AIM), also known as CD5L, may represent novel supportive therapy against various diseases, including metabolic syndrome and infectious diseases. The mechanisms AIM include modulating lipid metabolism other cells. We investigated M. infections vitro vivo. mouse model pneumonia, foamy were induced 6 wk after infection. bacteria localized these...
Abstract Exophiala dermatitidis is a black fungus that rarely causes respiratory infection. We report case of E . pneumonia with bronchiectasis relapsed after 11 months voriconazole (VRCZ) treatment in rheumatoid arthritis (RA) patient bronchiectasis. A 65‐year‐old woman RA and abnormal findings on chest radiography was referred for assessment chronic cough increased sputum production. She underwent bronchoscopy, identified from bronchoalveolar lavage fluid (BALF). lower tract infection were...
The long non-coding RNA (lncRNA) LINC00460 is involved in tumor growth, metastasis and drug resistance. present study investigated the clinical significance of expression patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer treated osimertinib. Osimertinib-resistant cells we derived from EGFR-mutant non-small-cell (NSCLC) cell lines, after which, small interfering (siRNA)-mediated silencing vitro-transcribed (IVT), synthetic transfection were used to...
The optimal bronchoscopy procedure for diagnosis of pulmonary nontuberculous mycobacteria (NTM) infection is unclear.This study investigated the usefulness bronchial brushing in NTM patients with suspected lung disease and nodular bronchiectasis on chest computed tomography (CT) images.Bronchoscopy was prospectively performed 69 clinically CT from December 2017 through 2019. Before after brushing, washing 20 or 40 mL normal sterile saline at same segmental subsegmental bronchi. samples fluid...
The impact of co-infection with other pathogenic microorganisms after initiation treatment for Mycobacterium avium complex pulmonary disease (MAC-PD) has not been clearly described. This study sought to clarify the clinical outcomes MAC antimycobacterial therapy MAC.Co-infection status was defined as detection than in at least two consecutive sputum cultures 6-24 months treatment. Chest computed tomography (CT) findings and culture results were compared between alone groups.The groups...
pulmonary disease (MAC-PD) is sometimes accompanied by co-infection with other pathogenic microorganisms such as
We herein report a case of Mycobacterium interjectum pulmonary disease (M. interjectum-PD) that improved considerably after azithromycin (AZM), rifampicin (RFP), and ethambutol (EB) therapy. A 69-year-old woman, managed locally for suspected NTM-PD based on chest computed tomography (CT) findings was referred to our hospital worsening productive cough six years the initial diagnosis. High-resolution CT showed right middle left lower lobe bronchiectasis with centrilobular nodules. Bronchial...
Abstract Background Amikacin liposome inhalation suspension (ALIS) improved sputum culture conversion rate at 6 months for patients with refractory Mycobacterium avium complex pulmonary disease (MAC-PD) in an international phase 3 trial. Patient characteristics and chest high-resolution CT (HRCT) findings associated ALIS effectiveness are poorly documented. Objective This study aimed to clarify MAC-PD months, elucidating patient findings. Methods We reviewed medical records of 12 whom...
Abstract Background: The impact of co-infection with other pathogenic microorganisms after initiation treatment for pulmonary Mycobacterium avium complex (MAC) disease has not been clearly demonstrated. This study sought to clarify clinical outcomes MAC antimycobacterial therapy MAC.Methods: Co-infection status was designated as the detection than in at least two consecutive sputum cultures 6-24 months treatment. Chest computed tomography (CT) findings and culture results were compared...
Abstract Background: The ATS/JRS/ALAT Guidelines for the Diagnosis of Hypersensitivity Pneumonitis (GL HP) were published in 2020. Humidifier lung and summer-type HP are forms HP, but it is unclear whether they can be diagnosed using GL HP. This study examined level confidence with which humidifier Methods: Data from 23 patients 20 (mean age, 67.3 57.4 years, respectively) between October 2012 January 2022 retrospectively reviewed. We evaluated high resolution computed tomography (HRCT)...