A5102812226- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- IL-33, ST2, and ILC Pathways
- Lipid metabolism and biosynthesis
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
University of Regensburg
2020-2024
Leibniz Association
2022-2024
Leibniz Institute for Immunotherapy
2022-2024
University of Michigan–Ann Arbor
2021
Michigan Medicine
2021
University Hospital Regensburg
2020
Specialized regulatory T (Treg) cells accumulate and perform homeostatic regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg exist how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of 33 (IL-33) receptor ST2-expressing tissue cells, which resided the spleen lymph nodes. Global chromatin...
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg with these functions healthy tissues. Single-cell chromatin accessibility profiles of murine defined a conserved, microbiota-independent tissue-repair signature prevailing footprint the transcription factor BATF. This signature, combined gene expression profiling TCR fate mapping, identified population tissue-like peripheral blood expressed...
CD8 T lymphocytes are classically viewed as cytotoxic cells. Whether human cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that not only mediated cytotoxicity but also promoted remodeling. Activated could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial for enhanced potential. Blocking EGFR or effector cytokines IFN-γ TNF inhibit This regenerative tumor...
Engineered regulatory T cell (Treg cell) therapy is a promising strategy to treat patients suffering from inflammatory diseases, autoimmunity, and transplant rejection. However, in many cases, disease-related antigens that can be targeted by Treg cells are not available. In this study, we introduce class of synthetic biosensors, named artificial immune receptors (AIRs), for murine human cells. AIRs consist three domains: (a) extracellular binding domain tumor necrosis factor (TNF)-receptor...
Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is caused by accumulation of excess lipids in hepatocytes. Genome wide association studies have identified strong NAFLD with non-synonymous E167K amino acid mutation transmembrane 6 superfamily member 2 (TM6SF2) protein. The affects TM6SF2 stability and its carriers display increased hepatic levels lower serum triglycerides. While similar phenotype evident mice knockdown, effects on lipid metabolism not completely understood....