A5046744169- Breast Implant and Reconstruction
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Body Contouring and Surgery
- Anatomy and Medical Technology
- Immune Cell Function and Interaction
- Digital Imaging in Medicine
- Immunotherapy and Immune Responses
- Wound Healing and Treatments
- Cancer Risks and Factors
- 3D Shape Modeling and Analysis
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Breast Cancer Treatment Studies
- Body Image and Dysmorphia Studies
- Congenital heart defects research
- Orthopedic Infections and Treatments
- Facial Rejuvenation and Surgery Techniques
- Botulinum Toxin and Related Neurological Disorders
- Face recognition and analysis
- Surgical site infection prevention
- Peripheral Nerve Disorders
University Hospital Regensburg
2020-2024
Regensburg University of Applied Sciences
2020-2024
University of Regensburg
2020-2023
Caritas Hospital
2021-2023
Aesthetic Surgery Center
2021
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg with these functions healthy tissues. Single-cell chromatin accessibility profiles of murine defined a conserved, microbiota-independent tissue-repair signature prevailing footprint the transcription factor BATF. This signature, combined gene expression profiling TCR fate mapping, identified population tissue-like peripheral blood expressed...
CD8 T lymphocytes are classically viewed as cytotoxic cells. Whether human cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that not only mediated cytotoxicity but also promoted remodeling. Activated could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial for enhanced potential. Blocking EGFR or effector cytokines IFN-γ TNF inhibit This regenerative tumor...
Lipofilling is an option for breast reconstruction after tumor resection to avoid the complications of implant-based reconstruction. Although some concerns exist regarding oncological safety tissue rich in mesenchymal stem cells with their proangiogenic and proliferation-supportive properties, there are also reports that adipose-tissue-derived can exhibit antitumoral properties. We isolated primary cells. Both conditioned medium exosomes were harvested from cell culture used treat cancer...
Abstract Purpose The aim of our study was to examine the surgical outcome and complications (efficiency) as well incidence locoregional recurrence distant metastases (oncological safety) in patients who underwent autologous fat grafting (AFG) breast following cancer surgery. Methods In monocentric cohort study, retrospective prospective data were collected from all consecutive AFG after between 2008 2020; a total 93 met inclusion criteria. Results Our long-term results showed no increase...
Lipofilling is a popular technique to treat volume loss in aging patients. The isolated adipose tissue composed of adipocytes and stromal vascular fraction cells, which include adipose-derived stem cells (ASC). We hypothesize that the patient's wrinkle severity scale (WSS) satisfaction on global aesthetic improvement (GAIS) can be improved after using concentrated lipoaspirate. Fourteen patients (54 years ± 11.09 years) with midface area underwent waterjet-assisted liposuction (Human Med AG,...
In plastic surgery, lipofilling is a frequent procedure. Unsatisfactory vascularization and impaired cell vitality can lead to unpredictable take rates in the fat graft. The proliferation neovascularization inducing properties of adipose tissue-derived stem cells may contribute solve this problem. Therefore, enrichment grafts with studied intensively. However, it difficult compare these studies because many factors-often not precisely described-are influencing results. Our study summarizes...
Background: Lipofilling is one of the most often performed surgical procedures in plastic and reconstructive surgery. Lipoaspirates provide a ready source stem cells secreted factors that contribute to neoangiogenesis fat graft survival. However, regulations about enrichment these beneficial are ambiguous. In this study, authors tested whether combination centrifugation homogenization allowed viable lipoaspirates through selective removal tumescent solution, blood, released lipids without...
In this trial, we used a previously developed prototype software to assess aesthetic results after reconstructive surgery for congenital breast asymmetry using automated anthropometry. To prove the consensus between manual and automatic digital measurements, evaluated by comparing measurements of 46 breasts.Twenty-three patients who underwent at our institution were examined 3D surface imaging. Per patient, 14 computer-based anthropometric obtained according standardized protocol. Manual as...
Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45
Lipofilling is an option for breast reconstruction after tumor resection to avoid the complications of implant-based reconstruction. Although some concerns exist regarding oncological safety a tissue rich in mesenchymal stem cells with their proangiogenic and proliferation-supportive properties, there are also reports that adipose tissue-derived can exhibit antitumoral properties. We isolated primary cells. Both conditioned medium exosomes were harvested from cell culture used treat cancer...
Abstract Purpose Lipofilling has been established as a standard technique for contour enhancement following breast reconstruction. However, there is paucity in current literature regarding the use of this complete reconstruction female an alternative to conventional techniques, such expander or flap-based procedures. In particular, influence pre-operative irradiation successful rarely examined published studies. Here, authors describe their experience with fat injection pre-radiated breasts...
Vitamin C is an essential nutrient for humans and involved in a plethora of health-related functions. Several studies have shown connection between vitamin intake improved resistance to infections that involves the immune system. However, body cannot store both elevated oral intake, intravenous application certain disadvantages. In this study, we wanted show new formulation liposomal packaging C. Using freeze etching electron microscopy, formed liposomes. With novel approach post-processing...
Autologous lipotransfer is a promising method for tissue regeneration, because white adipose contains heterogeneous cell population, including mesenchymal stem cells, endothelial immune and adipocytes. In order to improve the outcome, can be processed before application. this study, we investigated changes caused by mechanical processing. Lipoaspirates were using sedimentation, first-time centrifugation, shear-force homogenization, second-time centrifugation. The average adipocyte size,...
Congenital breast asymmetry is a serious gynecological malformation for affected patients. The condition hits young women in puberty and associated with socio-esthetic handicap, depression, psychosexual problems. Surgical treatment usually early the patient's lifetime, so long-term sustainable solution important. Although postoperative outcome has been evaluated several studies before, this study first to analyze which objective parameters have greatest influence on subjective satisfaction...
Abstract We present the Regensburg Breast Shape Model (RBSM)—a 3D statistical shape model of female breast built from 110 scans acquired in a standing position, and first publicly available. Together with model, fully automated, pairwise surface registration pipeline used to establish dense correspondence among is introduced. Our method computationally efficient requires only four landmarks guide process. A major challenge when modeling breasts surface-only non-separability thorax. In order...
Abstract Aims Congenital breast asymmetry represents a particular challenge to the classic techniques of plastic surgery given young age patients at presentation. This study reviews and compares long-term results traditional augmentation using silicone implants more innovative technique lipografting. Methods To achieve this, we not only captured subjective parameters such as satisfaction with outcome symmetry, but also objective including volume anthropometric measurements. The examination...
The lack of supportive Schwann cells in segmental nerve lesions seems to be one cornerstone for the problem insufficient regeneration. Lately, adipose-tissue-derived stem (ASCs) differentiated towards SC (Schwann cell)-like seem fulfill some needs ameliorated recovery. In this study, three differentiation protocols were investigated their ability differentiate ASCs from rats into specialized phenotypes. (dASCs) compared expressions neurotrophins (NGF, GDNF, BDNF), myelin markers (MBP, P0),...
Abstract Purpose To assess precise topographic changes of the breast, objective documentation and evaluation pre- postoperative results are crucial. New technologies for mapping body using digital, three-dimensional surface measurements have offered novel ways to numerically female breast. Due lack clear demarcation points breast contour, selection landmarks on is highly dependent examiner, and, therefore, prone error when conducting before-after comparisons same This study describes an...
Since the first use of silicone implants by Cronin in 1962, there have been several attempts to introduce alternative filling materials for breast on market. A promising new development are lightweight implants, whose filler material is one third lighter than conventional gel. While these used primarily aesthetic augmentation, a benefit could be expected particularly post-mastectomy reconstruction.Since 2019, 92 operations using performed at our clinic, 61 them reconstruction after...