Background: For many years, advancements in hand joint replacement (JR) were relatively minor compared to those for large joints. However, the caution previously exercised due high complication rates is gradually being replaced by expanding use of JR therapies small joints hand. Despite this progress, there a lack comprehensive data on outcomes and optimal infrastructure required meet growing demand these therapies. Methods: This study examined trends revision thumb carpometacarpal (CMC-1)...

Lips significantly influence facial aesthetics, driving the growing demand for lip augmentation procedures, particularly bullhorn lift. As aesthetic medicine becomes more diverse with globalization, understanding how ethnicity affects perceptions of lips is increasingly important. To examine philtrum length and proportions in context different ethnic backgrounds, recognizing increasing globalization beauty standards. Five frontal images females from groups-African, Asian, Caucasian, Latino,...

Mesenchymal stem cells (MSCs) have been described in breast cancer models to migrate towards carcinoma and integrate into tumor associated stroma supporting growth, increasing their metastatic potency contributing tumor-angiogenesis. Platelet-derived growth factor (PDGF) isoforms (AA, BB, CC) stimulate survival motility of MSCs certain other cell types. Noteworthy, carcinomas are known express PDGF. We aim further shed light on i) the relevance different PDGF adipose tissue derived (ASCs)...

BACKGROUND:Perioperatively, patients' hemodynamics are modulated predominantly by intravenous fluid administration and vasoactive pharmacological support. Vasopressor agents suspected to be detrimental on free flap survival the cause of vasoconstriction pedicle with consecutive reduce d overall perfusion aggravation dissection. OBJECTIVE:A novel, standardized restrictive perioperative hemodynamic management was assessed for its feasibility in clinical practice patients undergoing breast...

Lipofilling is a popular technique to treat volume loss in aging patients. The isolated adipose tissue composed of adipocytes and stromal vascular fraction cells, which include adipose-derived stem cells (ASC). We hypothesize that the patient's wrinkle severity scale (WSS) satisfaction on global aesthetic improvement (GAIS) can be improved after using concentrated lipoaspirate. Fourteen patients (54 years ± 11.09 years) with midface area underwent waterjet-assisted liposuction (Human Med AG,...

Background: Multiple symmetric lipomatosis (MSL) is defined as a disorder of nonencapsulated adipose tissue growth. Its prevalence indicated 1:25,000 and affects, stated in the literature, mainly Mediterranean males (male:female ratio 15:1). Phenotypes are still classified by Donhauser 1991. We report clinical phenotypic data largest patient cohort investigated Germany so far. Methods: Forty-five patients diagnosed with MSL at University Hospital Regensburg between 2007 2017 were...

Autologous fat grafts and adipose-derived stem cells (ASCs) can be used to treat soft tissue defects. However, the results are inconsistent sometimes comprise resorption necrosis. This might due insufficient vascularization. Platelet-rich plasma (PRP) is a source of concentrated autologous platelets. The growth factors cytokines released by platelets facilitate angiogenesis. simultaneous use PRP improve regeneration potential grafts. optimal ratio has yet elucidated. A byproduct preparation...

Abstract Background Breast reconstruction is an important coping tool for patients undergoing a mastectomy. There are numerous surgical techniques in breast surgery (BRS). Regardless of the technique used, creating symmetric outcome crucial and plastic surgeons. Three-dimensional surface imaging enables surgeons to assess outcome’s symmetry BRS. To discriminate between autologous alloplastic techniques, we analyzed both using objective optical computerized analysis. Software was developed...

Abstract Introduction Multiple symmetric lipomatosis (MSL) (syn.: Launois–Bensaude Syndrome, benign lipomatosis) is a rare disease of fatty tissue. The pathophysiology MSL still remains unclear, although several approaches have been described in order to understand it. Beside morphological characteristics and some molecular cell biological approaches, little known about the histological immunohistochemical characterization adipose tissue from patients with MSL. Methods From 45 our database,...

The superficial circumflex iliac artery perforator (SCIP) flap is a well-documented, thin, free tissue with minimal donor site morbidity, and has the potential to become new method for resurfacing moderate-size skin defects. aim of this study describe an easy, reliable, systematic, standardized approach preoperative SCIP design characterization, using color-coded duplex sonography (CCDS). A list customized settings straightforward algorithm are presented, which easily applied by operator...

Facial palsy (FP) is a debilitating nerve pathology. Cross Face Nerve Grafting (CFNG) describes surgical technique that uses grafts to reanimate the paralyzed face. The sural has been shown be reliable graft with little donor side morbidity. Therefore, we aimed investigate microanatomy of nerve. Biopsies were obtained from 15 FP patients who underwent CFNG using grafts. Histological cross-sections fixated, stained PPD, and digitized. Histomorphometry validated software-based axon...

Breast Carcinoma is the most common malign tumor disease in women. 20-30% of these tumors have to be treated by removing all breast tissue. After that kind therapeutic procedure, women are severely traumatized and ask for reconstruction. The goldstandard reconstruction free perforator flap from lower abdomen (DIEAP-flap), which can provide body-own tissue natural shape reconstructed breast.Many studies evaluate but neglect skin sensitivity. Claim this study was compare important part on two...

Background: As the leading complication of abdominoplasty, seroma formation might represent an inflammatory process in response to surgical trauma. This prospective randomized trial investigated whether local administration antiinflammatory agent triamcinolone could prevent accumulation. Methods: Weekly and cumulative volumes were compared between study groups A, B, C over a 4-week follow-up (group with drain, without triamcinolone; group C, triamcinolone). Aspirated samples analyzed by...

Technical aspects are of utmost significance for an efficient execution in designing perforator flaps with high-resolution color-coded Duplex sonography (CCDS). The following study evaluates decisive factors a successful microvessel examination conducted by the microsurgeon. knowledge presented this was based on series more than 200 planned CCDS. Flap reconstructions were performed at University Hospital Regensburg, Germany, from July 2013 to January 2021. Standard ultrasound (US) devices...

Duchenne muscular dystrophy (DMD) consists of a lack in the expression subsarcolemmal protein dystrophin causing progressive muscle dysfunction. Among widely applied animal models DMD research is C57BL/1010ScSn-Dmdmdx mouse, commonly referred to as "mdx mouse". The potential benefit novel interventions this model often assessed by variables such functional improvement, histological changes, and creatine kinase (CK) serum levels an indicator for extent situ damage.Our objective was determine...

Multiple symmetric lipomatosis is a rare disease characterized by the excessive growth of uncapsulated masses adipose tissue. Although etiology has yet to be elucidated, connection brown tissue been proposed recently. The mTOR pathway which found regulated in lipomatous as well associated with can inhibited compound called rapamycin.We isolated derived stem cells from both affected and unaffected treated these different concentrations rapamycin.The differences proliferation differentiation...

While complication rates in free tissue transfers have continuously decreased over time due to improved techniques, the intraoperative use of vasopressors and their negative effects on flap microcirculation patency anastomoses remains controversial. To further elucidate this matter, retrospective study examines effect gracilis muscle fasciocutaneous anterolateral thigh (ALT) flaps for lower extremity reconstruction.A total 425 patients underwent 437 limb reconstruction. The series was...

Facial palsy (FP) is a functional disorder of the facial nerve involving paralysis mimic muscles. According to principle “time muscle,” early surgical treatment tremendously important for preserving musculature if there are no signs function recovery. In 49-year-old female patient, even 19 months after onset FP, successful neurotization was still possible by V-to-VII transfer and cross-face grafting. Our patient suffered from complete FP vestibular schwannoma surgery. With continuous...

Background: A commonly seen issue in facial palsy patients is brow ptosis caused by paralysis of the frontalis muscle powered frontal branch nerve. Predominantly, static methods are used for correction. Functional restoration concepts include transfer deep temporal trigeminal nerve and cross-facial grafts. Both techniques can neurotize original mimic muscles early cases or power transplants late cases. Because axonal capacity particularly important graft procedures, authors investigated...