A5090977257- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Kruppel-like factors research
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Genetic and Kidney Cyst Diseases
- Endometriosis Research and Treatment
- Hormonal Regulation and Hypertension
- Eosinophilic Esophagitis
- Nephrotoxicity and Medicinal Plants
- MicroRNA in disease regulation
- Pregnancy and Medication Impact
- Connective Tissue Growth Factor Research
- Ferroptosis and cancer prognosis
- Ion Transport and Channel Regulation
- Biomedical Research and Pathophysiology
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Chronic Lymphocytic Leukemia Research
- Folate and B Vitamins Research
- Mesenchymal stem cell research
University of Pennsylvania
2019-2025
Ruijin Hospital
2022-2024
Yueyang Hospital
2015-2024
Shanghai University of Traditional Chinese Medicine
2015-2024
Shanghai Jiao Tong University
2022-2024
Civil Aviation Administration of China
2023
Stony Brook University
2021
Pediatric Nephrology of Alabama
2018
Shanghai University
2017-2018
Carrier (United States)
2018
<b><i>Background/Aims: </i></b>Renal interstitial fibrosis is a hallmark of progressive chronic kidney disease (CKD). Previous studies reported that kruppel-like factor 15 (KLF15) an important regulator cardiac and could reduce the expression extracellular matrix in mesangial cells. However, role this transcription renal has not been reported. <b><i>Methods: </i></b>In study, we examined KLF15 remnant 5/6 nephrectomized rats 12 or 24 weeks...
COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, specific treatments are lacking. Here, we constructed a transgenic mouse model by generating mutation (Col4a3 p.G799R) previously from one large family into mice. We observed that caused pathological decrease in intracellular secreted collagen IV α3α4α5 heterotrimers. The mutant α3 chains abnormally accumulated...
Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules result in progressive fibrotic CKD (chronic disease). Studies have revealed the relationship between tubular epithelial and fibrogenesis. However, underlying mechanism remains unclear. Hippo pathway components were evaluated complete/incomplete I/R (ischaemia/reperfusion) rat models, HK-2 human biopsy samples. We found that expression levels changed dynamically during...
MANBA is a kidney disease risk gene that alters tubular endolysosomal function, inducing inflammasome activation and fibrosis.
Background Podocyte injury is the hallmark of proteinuric kidney diseases, such as FSGS and minimal change disease, destabilization podocyte’s actin cytoskeleton contributes to podocyte dysfunction in many these conditions. Although agents, glucocorticoids cyclosporin, stabilize cytoskeleton, systemic toxicity hinders chronic use. We previously showed that loss kidney-enriched zinc finger transcription factor Krüppel-like 15 (KLF15) increases susceptibility disease attenuates salutary...
Genome-wide association studies (GWASs) have identified more than 1000 loci where genetic variants correlate with kidney function. However, the specific genes, cell types, and mechanisms influenced by these remain largely uncharted. Here, we glutathione-specific gamma–glutamylcyclotransferase 1 ( CHAC1 ) on chromosome 15 as affected GWAS analyzing human gene expression methylation information. Both RNA protein were expressed in loop of Henle region mouse kidneys, was higher patients carrying...
Chronic kidney disease (CKD) is a prevalent renal disorder with various risk factors. Emerging evidence indicates that the transcriptional factor CCAAT/enhancer binding protein alpha (C/EBPα) may be associated fibrosis. However, precise role of C/EBPα in CKD progression remains unexplored. We investigated involvement using two distinct mouse models induced by folic acid (FA) and unilateral ureteral obstruction (UUO). Additionally, we used RNA sequencing KEGG analysis to identify potential...
<b><i>Background/Aims:</i></b> Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder with mutations in <i>PKD1</i> or <i>PKD2</i>. This study aimed to identify novel and <i>PKD2</i> Chinese patients ADPKD. <b><i>Methods:</i></b> Mutational analyses of both <i>PKD</i> genes were performed 120 families ADPKD using long-range PCR targeted next-generation...
Podocyte apoptosis is a common mechanism driving progression in Alport syndrome (AS). This study aimed to investigate the of podocyte caused by COL4A3 mutations.We recruited patients with autosomal dominant AS (ADAS). Patients minimal change disease (MCD) were as controls. Microarray analysis was carried out on isolated glomeruli from and validated. Then, corresponding mutant human podocytes (p.C1616Y) 129 mice (p.C1615Y, murine homolog p.C1616Y) constructed. The highest differentially...
Abstract Numerous studies have proven the critical role of macrophages in renal fibrosis process. Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play ubiquitous regulating macrophage activities and proinflammatory pathways. However, precise GPER1 macrophage-mediated is unknown. In this study, we aimed investigate function UUO-induced model. Compared vehicle-treated ovariectomized (OVX) female male unilateral ureteral obstruction (UUO)...
Angiotensin II (Ang II) has been regarded as an important profibrogenic cytokine in renal fibrosis. Krüppel-like factor 15 (KLF15) identified negative transcription However, little is known about the role of KLF15 Ang II-induced fibrosis.In this study, we randomized mice into a control group, group or plus losartan group. expression was examined with real-time PCR and immunofluorescence these groups. In vitro, by Western blot rat fibroblasts (NRK-49F) stimulated II, effect altered on...
ABSTRACT Background Few studies have evaluated the treatment of immunoglobulin A nephropathy (IgAN) patients with nephrotic syndrome (NS) and mesangioproliferative glomerulonephritis (MPGN). The aim this study was to compare therapeutic effects oral glucocorticoids (GCS) combined intravenous cyclophosphamide (CTX) GCS alone in MPGN-IgAN NS. Methods Biopsy-proven primary IgAN who were aged ≥14 years at diagnosis, had coexistent NS MPGN estimated glomerular filtration rate (eGFR) ≥15...
Voriconazole is mainly used to treat progressive and potentially life-threatening infections in immunocompromised patients. The adverse drug reactions related voriconazole are varied. In some rare cases, the use of can result myelodysplastic syndrome (MDS)-like reactions.Here, we present a case systemic lupus erythematosus patient with fungal infection that developed MDS-like after treatment voriconazole. was admitted hospital because 3 days chest tightness dyspnea. After admission,...
This study investigates the link between genetic variants associated with kidney function and immunoglobulin A (IgA) nephropathy (IgAN) progression.
Diabetic kidney disease (DKD) is a prevalent and debilitating complication of diabetes characterized by progressive renal function decline lack effective treatment options. Here, we investigated the role transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) in DKD pathogenesis. Analysis biopsy samples revealed increased C/EBPα expression patients with DKD. Using RNA sequencing proteomics, explored mechanisms through which contributes to Our findings demonstrated that exacerbated...