Liangliang He

ORCID: 0000-0002-2169-4326
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About
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Research Areas
  • Plant Molecular Biology Research
  • Plant Reproductive Biology
  • Plant nutrient uptake and metabolism
  • Plant Gene Expression Analysis
  • Genetic and Kidney Cyst Diseases
  • Herpesvirus Infections and Treatments
  • Cytomegalovirus and herpesvirus research
  • Plant biochemistry and biosynthesis
  • Legume Nitrogen Fixing Symbiosis
  • Plant tissue culture and regeneration
  • Plant Parasitism and Resistance
  • Photosynthetic Processes and Mechanisms
  • Plant Stress Responses and Tolerance
  • RNA Research and Splicing
  • Hippo pathway signaling and YAP/TAZ
  • Anesthesia and Pain Management
  • Renal and related cancers
  • Animal Disease Management and Epidemiology
  • Fluid Dynamics Simulations and Interactions
  • Opioid Use Disorder Treatment
  • Erythropoietin and Anemia Treatment
  • Fermentation and Sensory Analysis
  • Pain Management and Opioid Use
  • Chromosomal and Genetic Variations
  • Seed Germination and Physiology

Xishuangbanna Tropical Botanical Garden
2013-2025

Jinan University
2021-2025

University of Chinese Academy of Sciences
2020-2024

Chinese Academy of Sciences
2013-2024

University of California, San Francisco
2022-2024

South China Agricultural University
2023-2024

Institute of Grassland Research
2024

Capital Medical University
2019-2024

Hansoh Pharma (China)
2023

Center for Excellence in Molecular Plant Sciences
2020-2023

Fruit aroma is an important quality with respect to consumer preference, but the most compounds and their genetic regulatory mechanisms remain elusive.In this study, we qualitatively analysed volatile in pulp skin of five table grape cultivars three types (muscat, strawberry, neutral) using solid-phase microextraction gas chromatography/mass spectrometry. We identified 215 compounds, including 88 esters, 64 terpenes, 29 alcohols, found significant differences number between skin, especially...

10.1186/s12870-023-04191-1 article EN cc-by BMC Plant Biology 2023-03-31

Jatropha curcas is a promising renewable feedstock for biodiesel and bio-jet fuel production. To study gene expression in different tissues throughout development under stress conditions, we examined total of 11 typical candidate reference genes using real-time quantitative polymerase chain reaction (RT-qPCR) analysis, which widely used validating transcript levels studies. The stability these was assessed across 20 samples, including various at vegetative reproductive stages desiccation...

10.3390/ijms141224338 article EN International Journal of Molecular Sciences 2013-12-13

Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules result in progressive fibrotic CKD (chronic disease). Studies have revealed the relationship between tubular epithelial and fibrogenesis. However, underlying mechanism remains unclear. Hippo pathway components were evaluated complete/incomplete I/R (ischaemia/reperfusion) rat models, HK-2 human biopsy samples. We found that expression levels changed dynamically during...

10.1042/cs20150385 article EN cc-by Clinical Science 2015-11-17

Blockage of the renin-angiotensin II system (RAS) prevents or delays albuminuria in diabetic patients. The aim this study was to investigate inhibitory mechanism angiotensin receptor blocker olmesartan on a murine model nephropathy.Male db/db mice were fed with placebo 20 mg/kg by daily gavage for 12 weeks. Conditionally immortalized mouse podocytes treated glucose, II, p38 inhibitor s8307 different experimental conditions after differentiation.Olmesartan reduced without change body weight...

10.1159/000452588 article EN cc-by-nc-nd Kidney & Blood Pressure Research 2016-01-01

Abstract Plant-specific WOX family transcription factors play important roles ranging from embryogenesis to lateral organ development. The WOX1 factors, which belong the modern clade of family, are known regulate outgrowth leaf blade specifically in mediolateral axis; however, role compound development remains unknown. Phylogenetic analysis whole tomato (Solanum lycopersicum) indicates that there 10 members represent modern, intermediate, and ancient clades. Using phylogenetic a reverse...

10.1093/jxb/eraa574 article EN cc-by Journal of Experimental Botany 2020-12-03

Anthocyanins and proanthocyanins (PAs) are two end products of the flavonoid biosynthesis pathway. They believed to be synthesized in endoplasmic reticulum then sequestered into vacuole. In Arabidopsis thaliana, TRANSPARENT TESTA 19 (TT19) is necessary for both anthocyanin PA accumulation. Here, we found that MtGSTF7, a homolog AtTT19, essential accumulation but not required Medicago truncatula. MtGSTF7 was induced by regulator LEGUME ANTHOCYANIN PRODUCTION 1 (LAP1), its tissue expression...

10.1093/jxb/erac112 article EN cc-by Journal of Experimental Botany 2022-03-12

Abstract Legume leaves exhibit diverse compound forms, with various regulatory mechanisms underlying the development. The transcription factor‐encoding KNOXI genes are required to promote leaflet initiation in most compound‐leafed angiosperms. In non‐IRLC (inverted repeat‐lacking clade) legumes, expressed leaf primordia but not others (IRLC). Recent studies have highlighted LFY genes' role regulating across legumes. functions development well understood IRLC legumes remain unclear Soybean, a...

10.1111/ppl.70092 article EN Physiologia Plantarum 2025-01-01

The BRASSINAZOLE-RESISTANT (BZR) family of transcription factors (TFs) are positive regulators in the biosynthesis brassinosteroids. latter is a class steroid hormones that affect variety developmental and physiological processes plants. BZR TFs play essential roles regulation plant growth development, including multiple stress-resistance functions. However, evolutionary history individual expression patterns legume genes has not been determined. In this study, we performed genome-wide...

10.3389/fpls.2018.01332 article EN cc-by Frontiers in Plant Science 2018-09-19

Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal constitutes a major pathology associated SCI stroke and strongly correlates neurological outcomes. Biomarkers characterized by expression specific induction post-injury likely to better correlate severity recovery, demonstrating higher...

10.1002/ctm2.1650 article EN cc-by Clinical and Translational Medicine 2024-04-01

Summary Male sterility is an important tool for plant breeding and hybrid seed production. Male‐sterile mutants are largely due to abnormal development of either the sporophytic or gametophytic anther tissues. Tapetum, a key tissue, provides nutrients pollen development, its delayed degeneration induces abortion. Numerous bHLH proteins have been documented participate in tapetum angiosperms, but relatively little attention has given evolution involved developmental pathways across phylogeny...

10.1111/nph.16770 article EN New Phytologist 2020-06-28

The size of leaf and seed organs, determined by the interplay cell proliferation expansion, is closely related to final yield quality forage crops. Yet cellular molecular mechanisms underlying organ modulation remain poorly understood, especially in legumes. Here, MINI ORGAN1 (MIO1), which encodes an F-box protein SMALL LEAF AND BUSHY1 (SLB1) recently reported control lateral branching Medicago truncatula, was identified as a key regulator size. We show that loss-of-function MIO1/SLB1...

10.1093/jxb/erab033 article EN cc-by Journal of Experimental Botany 2021-01-26

Pea (Pisum sativum L.) is one of the most important legume crops in world, and it has attracted great attention for its high nutritive values. Recently, crop breeding program been focused on metabolic engineering (i.e., color, flavor, nutrition) to improve quality crop. As a major group transcription factors forming ternary MYB-bHLH-WD repeat protein (MBW) complex regulate anthocyanin biosynthesis pathway, members R2R3-MYB gene family have always focus research targets valuable product...

10.3389/fgene.2022.936051 article EN cc-by Frontiers in Genetics 2022-07-06

Abstract The milestone of compound leaf development is the generation separate leaflet primordia during early stages, which involves two linked but distinct morphogenetic events: initiation and boundary establishment for separation. Although some progress in understanding regulatory pathways each event have been made, it unclear how they are intrinsically coordinated. Here, we identify PINNATE-LIKE PENTAFOLIATA2 (PINNA2) gene encoding a newly identified GRAS transcription factor Medicago...

10.1093/plcell/koae033 article EN cc-by-nc-nd The Plant Cell 2024-02-06

Optimizing plant architecture is an efficient approach for breeders to increase crop yields, and phytohormones such as gibberellins (GAs) play important role in controlling growth. Medicago truncatula a model legume species, but the molecular mechanisms underlying its are largely unknown. In this study, we examined tobacco retrotransposon Tnt1-tagged mutant collection of M. identified dwarf increased branching 1 (dib1), which exhibited extreme dwarfism numbers lateral branches. By analysis...

10.1093/jxb/eraa364 article EN Journal of Experimental Botany 2020-08-11

Polarity complexes, including the PAR (Partitioning-defective), CRB (Crumbs) and SCRIB (Scribble) are required for physiologic establishment, stabilization, maintenance of a functional apical-basolateral polarity. Inactivation some polarity complexes results in cystic kidneys, defects commonly observed autosomal-dominant polycystic kidney disease (ADPKD); however, little is known about role that play ADPKD. Here, we demonstrate Scribble, core protein complex, down-regulated ADPKD cell lines...

10.1096/fj.201701376rr article EN The FASEB Journal 2018-03-12

In species with compound leaves, the positions of leaflet primordium initiation are associated local peaks auxin accumulation. However, role during late developmental stages and outgrowth leaves remains largely unknown. Using genome resequencing approaches, we identified insertion sites at four alleles LATERAL LEAFLET SUPPRESSION1 (LLS1) gene, encoding biosynthetic enzyme YUCCA1 in Medicago truncatula. Linkage analysis complementation tests showed that lls1 mutant phenotypes were caused by...

10.1111/nph.16539 article EN publisher-specific-oa New Phytologist 2020-03-14

Abstract Inadequate reference databases in RNA‐seq analysis can hinder data utilization and interpretation. In this study, we have successfully constructed a high‐quality transcript dataset, ZjRTD1.0, for Zoysia japonica , widely‐used turfgrass with exceptional tolerance to various abiotic stress, including low temperatures salinity. This dataset comprises 113,089 transcripts from 57,143 genes. BUSCO demonstrates completeness (92.4%) reduced proportions of fragmented (3.3%) missing (4.3%)...

10.1111/ppl.14280 article EN Physiologia Plantarum 2024-03-01
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