A5036082323- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Trauma and Emergency Care Studies
- Traumatic Brain Injury Research
- Sepsis Diagnosis and Treatment
- Ethics in Clinical Research
- Nerve Injury and Rehabilitation
- Mesenchymal stem cell research
- Scientific Computing and Data Management
- Neurogenesis and neuroplasticity mechanisms
- Spinal Dysraphism and Malformations
- Aortic Disease and Treatment Approaches
- Artificial Intelligence in Healthcare and Education
- Meta-analysis and systematic reviews
- Muscle activation and electromyography studies
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- Acute Ischemic Stroke Management
- Cardiac Arrest and Resuscitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomedical Text Mining and Ontologies
University of California, San Francisco
2019-2025
University of Alberta
2015-2025
University of San Francisco
2025
Neurological Surgery
2019-2025
University of Waterloo
2023-2025
San Francisco General Hospital
2020-2024
Universidad Católica de Santa Fe
2024
University of California, San Diego
2023
Washington University in St. Louis
2023
San Francisco VA Medical Center
2023
Secondary manifestations of spinal cord injury beyond motor and sensory dysfunction can negatively affect a person's quality life. Spinal is associated with an increased incidence depression anxiety; however, the mechanisms this relationship are currently not well understood. Human animal studies suggest that changes in composition intestinal microbiota (dysbiosis) mood disorders. The objective current study to establish model anxiety following cervical contusion rats determine whether play...
Rehabilitative training is one of the most successful therapies to promote motor recovery after spinal cord injury, especially when applied early injury. Polytrauma and management other medical complications in acute post-injury setting often preclude or complicate rehabilitation. Therefore, interventions that reopen a window opportunity for effective chronic injury would have significant therapeutic value. Here, we tested whether this could be achieved rats with (8 weeks) dorsolateral...
Abstract Chondroitin sulfate proteoglycans (CSPGs) act as potent inhibitors of axonal growth and neuroplasticity after spinal cord injury (SCI). Here we reveal that CSPGs also play a critical role in preventing inflammation resolution by blocking the conversion pro-inflammatory immune cells to pro-repair phenotype rodent models SCI. We demonstrate enzymatic digestion CSPG glycosaminoglycans enhances cell clearance reduces protein gene expression profiles at key time points. Analysis...
OBJECTIVE The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Corticosteroid Randomization After Significant Head (CRASH) prognostic models for mortality outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT CRASH model performances a contemporary cohort US patients. METHODS prospective 18-center Transforming Research Knowledge (TRACK-TBI) (enrollment years 2014–2018) enrolled...
IL-37, a member of the IL-1 family, broadly reduces innate inflammation as well acquired immunity. Whether antiinflammatory properties IL-37 extend to central nervous system remains unknown, however. In present study, we subjected mice transgenic for human (hIL-37tg) and wild-type (WT) spinal cord contusion injury then treated them with recombinant (rIL-37). hIL-37tg mice, expression was barely detectable in uninjured cords, but strongly induced at 24 h 72 after (SCI). Compared WT exhibited...
Diagnosis of spinal cord injury (SCI) severity at the ultra-acute stage is great importance for emergency clinical care patients as well potential enrollment into trials. The lack a diagnostic biomarker SCI has played major role in poor results We analyzed global gene expression peripheral white blood cells during acute phase and identified 197 genes whose changed after compared with healthy trauma controls direct relation to severity. Unsupervised coexpression network analysis several...
Abstract Cell therapy for spinal cord injury ( SCI ) is a promising strategy clinical application. Both bone marrow mesenchymal stromal cells MSC s; also known as marrow‐derived ‘mesenchymal stem cells’) and olfactory ensheathing OEC s) have demonstrated beneficial effects following transplantation in animal models of . However, due to the large number affecting parameters that determine success lack methodological consensus, comparison different works difficult. Therefore, we compared...
Cisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-dependent adverse event that can determine dosage limitations for cancer treatment. CIPN severity correlates with the amount of platinum detected in sensory neurons dorsal root ganglia (DRG). However, exact pathophysiology poorly understood, so chance developing neuroprotective treatment reduced. The aim this study was to mechanisms involved development.
Minocycline is a clinically available synthetic tetracycline derivative with anti-inflammatory and antibiotic properties. The majority of studies show that minocycline can reduce tissue damage improve functional recovery following central nervous system injuries, mainly attributed to the drug's direct anti-inflammatory, anti-oxidative, neuroprotective Surprisingly consequences minocycline's (i.e., antibacterial) effects on gut microbiota systemic immune response after spinal cord injury have...
There are a number of risk factors- from biological, psychological, and social domains- for non-specific chronic low back pain (cLBP). Many cLBP treatments target factors on the assumption that targeted factor is not just associated with but also cause (i.e, causal factor). In most cases this strong assumption, primarily due to possibility confounding variables. False assumptions about relationships between likely contribute generally marginal results treatments. The objectives study were a)...
Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly third of all chronic SCI may benefit from this intervention, variability outcomes can limit the functional impact. A bedside-to-bench was taken address variable response tetraplegic nerve surgery. We used hierarchical multiple factor analysis evaluate effects conditioning electrical stimulation (CES) on mouse...
Importance: Early outcome prediction after acute traumatic spinal cord injury (SCI) is challenging due to pathological complexities and population heterogeneity. Routinely collected data during standard medical practice, such as laboratory analytics, can be a surrogate of underlying pathophysiological processes used biomarker. We hypothesized that distinct temporal trends blood analytics could modeled SCI those would predict parameters. Objective: To test the hypothesis develop machine...
The bidirectional communication between the gastrointestinal tract and central nervous system appears to be linked intestinal microbiome. Research has shown that spinal cord injury (SCI) can disrupt gut microbiome, leading dysbiosis. These changes have several negative impacts, such as exacerbated systemic inflammation susceptibility infection. Probiotics administered mice with SCI been ameliorate dysbiosis, confer neuroprotection, improve locomotor recovery. However, probiotics also...
Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly third of all chronic spinal cord injury may benefit from this intervention, variability outcomes can limit the functional impact. A bedside bench was taken address variable response tetraplegic nerve surgery. Methods: We used hierarchical multiple factor analysis evaluate effects...
Rehabilitative training is an effective method to promote recovery following spinal cord injury (SCI), with lower efficacy observed in the chronic stage. The increased during subacute period associated a shift towards more adaptive or proreparative state induced by SCI. A potential link SCI-induced inflammation, which elevated period, and, as injection of lipopolysaccharide (LPS) alongside improves SCI, suggesting LPS could reopen window plasticity late after injury. Microglia may play role...
INTRODUCTION: Early prognosis in TBI is essential to support clinical decision-making, inform patients and relatives, advance research. The IMPACT prognostic model for 6-month outcomes was originally developed from an international dataset of moderate-severe (GCS =12; studies conducted 1984-1997). Multiple external validations have been performed but global data privacy regulations made sharing human subject largely infeasible, preventing validation updating combined contemporary datasets....
Abstract Purpose The relationship between pain experience and biomechanical impairment in chronic low back (LBP) is unclear. Among the broader literature, sex-based differences have been established. However, it unknown if relates to compromised movement patterns for patients with LBP. This study examined sex whether there are associations function Methods To capture variability among LBP patients, we quantified full-body quality based on extent that 3D postural trajectories deviated from...
Transplantation of bone marrow derived mesenchymal stromal cells (MSC) or olfactory ensheathing (OEC) have demonstrated beneficial effects after spinal cord injury (SCI), providing tissue protection and improving the functional recovery. However, changes induced by these their transplantation into injured remain largely unknown. We analyzed in transcriptome a contusion MSC OEC transplantation. The were injected immediately 7 days injury. mRNA segment was extracted microarray at 2 cell...
The reticulospinal tract (RtST) descends from the reticular formation and terminates in spinal cord. RtST drives initiation of locomotion postural control. axons form new contacts with propriospinal interneurons (PrINs) after incomplete cord injury (SCI); however, it is unclear if injured or uninjured make these connections. We completely transected all traced rats using a staggered model, where hemisection SCI at vertebra T10 followed by contralateral T7. In one group animals, T7 was...
Traumatic brain injury (TBI) is a major public health problem. Despite considerable research deciphering pathophysiology, precision therapies remain elusive. Here, we present large-scale data sharing and machine intelligence approaches to leverage TBI complexity. The Open Data Commons for (ODC-TBI) community-centered repository emphasizing Findable, Accessible, Interoperable, Reusable publication with persistent identifiers. Importantly, the ODC-TBI implements of individual subject data,...
Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal constitutes a major pathology associated SCI stroke and strongly correlates neurological outcomes. Biomarkers characterized by expression specific induction post-injury likely to better correlate severity recovery, demonstrating higher...