A5012134366- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- NF-κB Signaling Pathways
- Multiple Myeloma Research and Treatments
- Microtubule and mitosis dynamics
- Circadian rhythm and melatonin
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- bioluminescence and chemiluminescence research
- Chemotherapy-related skin toxicity
- Cholinesterase and Neurodegenerative Diseases
- Genetics, Aging, and Longevity in Model Organisms
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Mesenchymal stem cell research
- Nanoplatforms for cancer theranostics
- Drug-Induced Ocular Toxicity
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
- Colorectal Cancer Treatments and Studies
Biomedical Research Networking Center on Neurodegenerative Diseases
2016-2024
Universitat Autònoma de Barcelona
2016-2024
Universitat Pompeu Fabra
2022
Centro de Investigación Biomédica en Red
2016-2019
Cisplatin-induced peripheral neuropathy (CIPN) is a frequent serious dose-dependent adverse event that can determine dosage limitations for cancer treatment. CIPN severity correlates with the amount of platinum detected in sensory neurons dorsal root ganglia (DRG). However, exact pathophysiology poorly understood, so chance developing neuroprotective treatment reduced. The aim this study was to mechanisms involved development.
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity neurotoxicity often leads dose reduction or even premature cessation chemotherapy. Unfortunately, the limited knowledge about molecular mechanisms related lack effective treatments prevent development this clinical condition. In context, present work aimed determine exact involved in murine...
Abstract Background and Aims Cell culture is a fundamental experimental tool for understanding cell physiology. However, translating these findings to in vivo settings has proven challenging. Replicating donor tissue conditions, including oxygen levels, crucial achieving meaningful results. Nevertheless, conditions are often overlooked, particularly the context of chemotherapy‐induced neurotoxicity. Methods In this study, we investigated role levels primary neuronal cultures by comparing...
ABSTRACT Minocycline has been reported to be both beneficial and detrimental for nerve regeneration after peripheral injury. By reducing the inflammatory response, minocycline administration reduces pain neuroprotective effects, but it also inhibits Wallerian degeneration in distal stump, microglia macrophages activity on motor sensory neurons, which could reduce their intrinsic regenerative capacity. The aim of this study was determine if injury capacity motoneurons neurons a conditioning...