A5090237810- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Apelin-related biomedical research
- Intensive Care Unit Cognitive Disorders
- Acute Ischemic Stroke Management
- Pancreatic function and diabetes
- Visual perception and processing mechanisms
- Cancer, Lipids, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Neurological Disorders and Treatments
- Neural dynamics and brain function
- Peroxisome Proliferator-Activated Receptors
- Neurological Disease Mechanisms and Treatments
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Color perception and design
- Pharmacological Effects and Toxicity Studies
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Fatty Acid Research and Health
University of California, San Francisco
2014-2025
San Francisco VA Medical Center
2024-2025
Neurology, Inc
2025
San Francisco General Hospital
2015
University of Pennsylvania
2006-2009
Philadelphia University
2009
Rice University
2003-2004
<h3>Importance</h3> This observational study describes the efficacy and safety of rituximab in 5 patients with voltage-gated potassium channel (VGKC)–complex/leucine-rich, glioma-inactivated 1 (LGI1) antibody–associated encephalopathy. Rituximab is a monoclonal antibody that targets CD20 used to treat other neurologic nonneurologic diseases. <h3>Observations</h3> case series reports sequential seizure frequencies, modified Rankin Scale scores, VGKC-complex titers adult (median age, 65 years;...
Identification of a particular cause meningoencephalitis can be challenging owing to the myriad bacteria, viruses, fungi, and parasites that produce overlapping clinical phenotypes, frequently delaying diagnosis therapy. Metagenomic deep sequencing (MDS) approaches infectious disease diagnostics are known for their ability identify unusual or novel viruses thus well suited investigating possible etiologies meningoencephalitis.We present case 74-year-old woman with endophthalmitis followed by...
Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis rodents. Here, we have determined the role of resistin ob/ob mice that obese insulin resistant because genetic deficiency leptin. Loss obesity by further lowering metabolic rate without affecting food intake. Nevertheless, improved tolerance sensitivity these severely mice, largely enhancing insulin-mediated disposal muscle adipose tissue. In contrast, C57BL/6J with diet-induced but wild-type leptin...
Diets with high fat content induce steatosis, insulin resistance, and type 2 diabetes. The lipid droplet protein adipose differentiation-related (ADRP) mediates hepatic but whether this affects action in the liver or peripheral organs diet-induced obesity is uncertain. We fed C57BL/6J mice a high-fat diet simultaneously treated them an antisense oligonucleotide (ASO) against ADRP for 4 wk. Glucose homeostasis was assessed clamp tracer techniques. ASO decreased levels of triglycerides...
Although past studies have shown that visual information can be processed without awareness, the types and levels of this processing yet to determined. We used metacontrast masking explore unconscious priming effects white, blue, green stimuli generated on a color video display. found white prime tends act more like than blue one. Color confusions among unmasked masked primes calibrations display phosphors show physical rather perceptual properties best explain prime's effects. conclude in...
Sensing of peripheral hormones and nutrients by the hypothalamus plays an important role in maintaining glucose homeostasis. The hormone resistin impairs response to insulin liver other tissues. Here we demonstrate that normal mice delivered lateral cerebral ventricle increased endogenous production during hyperinsulinemic-euglycemic clamp, consistent with induction hepatic resistance. In agreement, central inhibited Akt phosphorylation expression glucose-6-phosphatase, enzyme regulating...
Resistin has been linked to components of the metabolic syndrome, including obesity, insulin resistance, and hyperlipidemia. We hypothesized that resistin deficiency would reverse hyperlipidemia in genetic obesity. C57Bl/6J mice lacking [resistin knockout (RKO)] had similar body weight fat as wild-type when fed standard rodent chow or a high-fat diet. Nonetheless, hepatic steatosis, serum cholesterol, very low-density lipoprotein (VLDL) secretion were decreased diet-induced obese RKO mice....
Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal constitutes a major pathology associated SCI stroke and strongly correlates neurological outcomes. Biomarkers characterized by expression specific induction post-injury likely to better correlate severity recovery, demonstrating higher...
The ε4 variant of human apolipoprotein E ( APOE4 ) is a key genetic risk factor for neurodegeneration in Alzheimer’s disease and elevated all-cause mortality humans. Understanding the factors mechanisms that can mitigate harmful effects has significant implications. In this study, we find inactivating VHL-1 (Von Hippel–Lindau) protein suppress mortality, neural behavioral pathologies caused by transgenic Caenorhabditis elegans . protective deletion are recapitulated stabilized HIF-1...
Recent research on neurodegenerative diseases has highlighted a pathophysiological cascade characterized by abnormal lipid accumulation within the brain. Although progress been made, role of metabolism following stroke remains unclear. This study aims to further explore changes in after stroke, with specific focus endoplasmic reticulum transmembrane protein 97 (TMEM97), which emerged as promising therapeutic target due its critical cholesterol metabolism. Spatial transcriptomic analyses...
Background: PCSK9, a key regulator of cholesterol metabolism, has been implicated in atherosclerosis. However, its potential role vascular cognitive impairment and dementia (VCID) remains elusive. We hypothesized that PCSK9 overexpression, exacerbated by high-fat diet (HFD), would promote neurovascular inflammation recapitulate VCID pathology. Methods: C57 mice were stratified into control, HFD, PCSK9+HFD groups. overexpression was induced via AAV injection, subjected to either normal or HFD...
Abstract Delirium is a neurologic syndrome characterized by inattention and cognitive impairment frequently encountered in the medically ill. Peripheral inflammation key trigger of delirium, but patient-specific immune responses associated with delirium development resolution are unknown. This retrospective cohort study prospectively collected biospecimens examines RNA sequencing from peripheral blood mononuclear cells adults hospitalized for COVID-19 to better understand factors (n = 64)....
ABSTRACT The inflammatory response induced by stroke can exacerbate injury to peri-infarct tissue. Microglia and other immune cells that mediate this require increased glycolytic flux during pro-inflammatory activation. These cells, unlike neurons most cell types, utilize hexokinase-2 (HK2) rather than hexokinase-1 for glycolysis, such HK2 inhibitors may selectively target them suppress post-ischemic inflammation. Here we compared the effects of non-selective hexokinase inhibitor...
Abstract L1CAM-positive extracellular vesicles (L1EV) are an emerging biomarker that may better reflect ongoing neuronal damage than other blood-based biomarkers. The physiological roles and regulation of L1EVs their small RNA cargoes following stroke is unknown. We sought to characterize L1EV RNAs assess signatures for diagnosing using weighted gene co-expression network analysis random forest (RF) machine learning algorithms. Interestingly, sequencing plasma from patients with control (n =...
Sarcoid polyneuropathy is a rare and clinically heterogeneous disorder that may be the initial presentation of sarcoidosis.We report clinical, electrophysiological, pathological findings patient who carried diagnosis sensory-predominant chronic inflammatory demyelinating (CIDP) for over decade but was ultimately found to have sarcoid polyneuropathy.A 36-year-old man presented with several-week history gait difficulty muscle cramps. He had CIDP not received lasting benefit from...