A5042687265- Musculoskeletal pain and rehabilitation
- Neonatal and fetal brain pathology
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neonatal Respiratory Health Research
- Blind Source Separation Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- HIV/AIDS Research and Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Psychology of Development and Education
- Cancer Immunotherapy and Biomarkers
- Fetal and Pediatric Neurological Disorders
- Cardiac Arrest and Resuscitation
- Neurobiology of Language and Bilingualism
- Advanced Battery Technologies Research
- Erythrocyte Function and Pathophysiology
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Advanced Neuroimaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Blood properties and coagulation
University of California, San Francisco
2019-2025
UCLA Health
2022
University of California, Los Angeles
2015-2020
Center for Autism and Related Disorders
2020
Families USA
2018
Center for Children
2018
RWTH Aachen University
1979-1990
Abstract Background There is mounting evidence for the presence of postacute sequelae severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), but there limited information on spectrum, magnitude, duration, and patterns these as well their influence quality life. Methods We assembled a cohort adults with documented history SARS-CoV-2 RNA positivity at ≥2 weeks past onset disease 2019 (COVID-19) symptoms or, if asymptomatic, first positive test. At 4-month intervals, we...
Mucin disulfide cross-links mediate pathologic mucus formation in muco-obstructive lung diseases. MUC-031, a novel thiol-modified carbohydrate compound, cleaves disulfides to cause mucolysis. The aim of this study was determine the mucolytic and therapeutic effects MUC-031 sputum from patients with cystic fibrosis (CF) mice disease (βENaC-Tg mice).We compared efficacy existing mucolytics (N-acetylcysteine (NAC) recombinant human deoxyribonuclease I (rhDNase)) using rheology measure elastic...
Abstract Purpose The relationship between pain experience and biomechanical impairment in chronic low back (LBP) is unclear. Among the broader literature, sex-based differences have been established. However, it unknown if relates to compromised movement patterns for patients with LBP. This study examined sex whether there are associations function Methods To capture variability among LBP patients, we quantified full-body quality based on extent that 3D postural trajectories deviated from...
Background: Self-monitoring by mobile phone applications offers new opportunities to engage patients in self-management. has not been examined thoroughly as a self-directed intervention strategy for self-management of multiple behaviors and states people living with HIV (PLH). Methods: PLH (n = 50), primarily African American Latino, were recruited from 2 AIDS services organizations randomly assigned daily smartphone 34) or biweekly Web-survey only 16) self-monitoring 6 weeks. Smartphone...
Abstract Background Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a risk factor for neonatal brain injury. We examined the timing and pattern of injury in mild HIE. Methods This retrospective cohort study includes infants with HIE treated at 9 hospitals. Neonatal MRIs were scored by 2 reviewers using validated classification system, discrepancies resolved consensus. Severity MRI (i.e., acute, subacute, chronic) was on subset that performed or before 8 days age....
Article Das Mini-Erythrozyten-Aggregometer: Ein neues Gerät zur schnellen Quantifizierung des Ausmaßes der Erythrozyten-aggregation Mini Erythrocyte Aggregometer: A New Apparatus for Rapid Quantification of the extent Aggregation was published on January 1, 1982 in journal Biomedical Engineering / Biomedizinische Technik (volume 27, issue 9).
Aim. To examine the child outcomes at 18-months post-birth of a population cohort women with antenatal depressed mood, half whom were randomly chosen to receive perinatal home visits from community health workers during pregnancy. Method. Pregnant in 24 neighbourhoods (98% participation) randomised by neighbourhood to: (1) standard clinic care (SC; 12 neighbourhoods; n = 594) or (2) Philani Intervention Program, visiting intervention plus (12 644). The physical and cognitive children mothers...
The consequences of maternal depressed mood on children's growth, health, and cognitive language development are examined over the first 3 years life.
Biomarker development is currently a high priority in neurodevelopmental disorder research. For many types of biomarkers (particularly diagnosis), reliability over short time periods critically important. In the field autism spectrum (ASD), resting electroencephalography (EEG) power spectral densities (PSD) are well-studied for their potential as biomarkers. Classically, such data have been decomposed into pre-specified frequency bands (e.g., delta, theta, alpha, beta, and gamma). Recent...
Autism spectrum disorder (ASD) is a neurodevelopmental associated with different genetic etiologies. Prospective examination of familial-risk infants informs understanding developmental trajectories preceding ASD diagnosis, potentially improving early detection. To compare outcomes and varying familial risk for across the first 3 years life. This longitudinal, prospective cohort study used data from 11 sites in Baby Siblings Research Consortium database. Data were collected between 2003...
The University of California, San Francisco (UCSF) Core Center for Patient-centric, Mechanistic Phenotyping in Chronic Low Back Pain (REACH) is one the three NIH Consortium (BACPAC) Research Programs Centers (MRCs). goal UCSF REACH to define cLBP phenotypes and pain mechanisms that can lead effective, personalized treatments patients across population. primary objective this research project address critical need new diagnostic prognostic markers, associated patient classification protocols...
The electroencephalography (EEG) data created in event-related potential (ERP) experiments have a complex high-dimensional structure. Each stimulus presentation, or trial, generates an ERP waveform which is instance of functional data. are made up sequences multiple trials, resulting longitudinal and moreover, responses recorded at electrodes on the scalp, adding electrode dimension. Traditional EEG analyses involve simplifications this structure to increase signal-to-noise ratio,...
ObjectiveTo evaluate the association of therapeutic hypothermia with magnetic resonance imaging (MRI) findings and 30-month neurodevelopment in term neonatal encephalopathy.Study designCross-sectional analysis (IQR 19.0-31.4) a prospective cohort mild-to-severe encephalopathy imaged on day 4 (1993-2017 institutional implementation 2007). MRI injury was classified as normal, watershed, or basal ganglia/thalamus. Abnormal motor outcome defined Bayley-II psychomotor developmental index <70,...
Background There is great interest in finding ways to identify patients who will develop toxicity cancer therapies. This has become especially pressing the era of immune therapy, where can be long-lasting and life-altering, primarily comes form immune-related adverse effects (irAEs). Treatment with first drugs this class, anti-programmed death 1 (anti-PD1)/programmed death-ligand (PDL1) checkpoint therapies, results grade 2 or higher irAEs up 25%–30% patients, which occur most commonly...
For chronic low back pain, the causal mechanisms between pathological features from imaging and patient symptoms are unclear. instance, disc herniations can often be present without symptoms. There remains a need for improved knowledge of pathophysiological that explore spinal tissue damage clinical manifestations pain disability. Spaceflight astronaut health provides rare opportunity to study potential longitudinally. disrupts diurnal loading on spine several lines evidence indicate...
Abstract The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss repetition and naming skills resulting from left posterior temporal inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted the disease (epicenters) investigate whether atrophy spreads through predetermined networks. First, used cross‐sectional structural MRI data individuals with lvPPA define...
Semantic behavioral variant (also referred to as right temporal) frontotemporal dementia is a newly described syndrome associated with focal anterior temporal lobe atrophy and distinctive combination of semantic changes. It considered the right-sided counterpart primary progressive aphasia, which it has overlapping neuropathological cognitive mechanisms. Although more known about how brain network alterations relate both losses (e.g., word comprehension deficits) gains hyper-fluency) in...
Isocitrate dehydrogenase (IDH)-mutant astrocytomas represent the most frequent primary intraparenchymal brain tumor in young adults, which typically arise as low-grade neoplasms that often progress and transform to higher grade despite current therapeutic approaches. However, genetic alterations underlying high-grade transformation disease progression of IDH-mutant remain inadequately defined. Genomic profiling was performed on 205 from 172 patients both initial treatment-naive recurrent...
Developing surrogates for computer models has become increasingly important addressing complex problems in science and engineering. This article introduces an artificial intelligent (AI) surrogate, referred to as the DeepSurrogate, analyzing functional outputs with vector-valued inputs. The relationship between output input is modeled infinite sequence of unknown functions, each representing at a specific location within domain. These spatially indexed functions are expressed through...
Abstract Purpose We aimed to identify factors associated with genetic testing awareness and use among a large sample of US cancer survivors participating in NCI’s Health Information National Trends Survey identified through the Surveillance, Epidemiology, End Results program, unique pilot study expanding number typically captured by HINTS. Methods analyzed 2021 HINTS-SEER data determine sociodemographic utilization germline using survey-weight-adjusted multivariable logistic regression. Of...