Nidhi S. Mundada
A5050960562- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Epilepsy research and treatment
- Neurobiology of Language and Bilingualism
- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Health, Environment, Cognitive Aging
- Radiomics and Machine Learning in Medical Imaging
- Memory and Neural Mechanisms
- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Creativity in Education and Neuroscience
- Advanced MRI Techniques and Applications
- Statistical Methods in Clinical Trials
- Parkinson's Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genomics and Rare Diseases
- Neurological Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
University of California, San Francisco
2020-2025
University Memory and Aging Center
2020-2025
University of Pennsylvania
2024
University of California, Davis
2020-2021
Abstract Early-onset (age < 65) Alzheimer’s disease is associated with greater non-amnestic cognitive symptoms and neuropathological burden than late-onset disease. It not fully understood whether these groups also differ in the associations between molecular pathology, neurodegeneration performance. We studied amyloid-positive patients early-onset (n = 60, mean age 58 ± 4, MMSE 21 6, 58% female) 53, 74 23 5, 45% who underwent neurological evaluation, neuropsychological testing,...
Abstract Introduction Ethnoracial differences in cerebrospinal fluid (CSF; amyloid beta 42 [Aβ42], total tau [t‐tau], phosphorylated 181 [p‐tau181], and plasma (p‐tau181, neurofilament light [NfL]) biomarkers of Alzheimer's disease (AD) are incompletely understood. Methods We performed cross‐sectional analyses with without adjustment for covariates comparing baseline CSF (Aβ42, t‐tau, p‐tau181) NfL) values 47 African Americans (AAs) matched to 141 non‐Hispanic Whites (NHWs) 43 Latinos (LAs)...
Abstract INTRODUCTION We aimed to describe baseline amyloid‐beta (Aβ) and tau‐positron emission tomograrphy (PET) from Longitudinal Early‐onset Alzheimer's Disease Study (LEADS), a prospective multi‐site observational study of sporadic early‐onset disease (EOAD). METHODS analyzed [18F]Florbetaben [18F]Flortaucipir (tau)‐PET cognitively impaired participants with clinical diagnosis mild cognitive impairment (MCI) or AD dementia aged < 65 years. Florbetaben scans were used distinguish EOAD...
Traumatic encephalopathy syndrome (TES) criteria were developed to aid diagnosis of chronic traumatic (CTE) pathology during life. Interpreting clinical and biomarker findings in patients with TES life necessitates autopsy-based determination the neuropathological profile. We report a clinicopathological series nine previous repetitive head impacts (RHI) classified retrospectively using recent research framework (100% male white/Caucasian, age at death 49-84) who completed antemortem...
Abstract Background Plasma phosphorylated tau (p-tau) has emerged as a promising biomarker for Alzheimer’s disease (AD). Studies have reported strong associations between p-tau and tau-PET that are mainly driven by differences amyloid-positive amyloid-negative patients. However, the relationship is less characterized within cognitively impaired patients with biomarker-supported diagnosis of AD. We conducted head-to-head comparison plasma p-tau217 in at clinical stage AD further assessed...
Magnetic resonance imaging (MRI) research has advanced our understanding of neurodegeneration in sporadic early-onset Alzheimer's disease (EOAD) but studies include small samples, mostly amnestic EOAD, and have not focused on developing an MRI biomarker. We analyzed scans to define the EOAD-signature atrophy a sample (n = 25) Massachusetts General Hospital (MGH) EOAD patients, investigated its reproducibility large longitudinal study (LEADS) 211), relationship magnitude with cognitive...
The neurological substrates of visual artistic creativity (VAC) are unknown. VAC is demonstrated here to occur early in frontotemporal dementia (FTD), and multimodal neuroimaging used generate a novel mechanistic hypothesis involving dorsomedial occipital cortex enhancement. These findings may illuminate mechanism underlying human creativity.
Abstract Many studies suggest that information about past experience, or episodic memory, is divided into discrete units called “events.” Yet we can often remember experiences span multiple events. Events occur in close succession might simply be linked because of their proximity to one another, but also build links between events farther apart time. Intuitively, some kind organizing principle should enable temporally distant become bridged memory. We tested the hypothesis memory exhibits a...
Abstract Objective The Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) seeks to provide comprehensive understanding of early‐onset disease (EOAD; onset <65 years), with the current study profiling baseline clinical, cognitive, biomarker, and genetic characteristics cohort nearing data‐collection mid‐point. Methods Data from 371 LEADS participants were compared based on diagnostic group classification (cognitively normal [ n = 89], amyloid‐positive EOAD 212], amyloid‐negative...
Abstract Approximately 5% of Alzheimer’s disease patients develop symptoms before age 65 (early-onset disease), with either sporadic (sporadic early-onset disease) or dominantly inherited (dominantly presentations. Both and are characterized by brain amyloid-β accumulation, tau tangles, hypometabolism neurodegeneration, but differences in topography magnitude these pathological changes not fully elucidated. In this study, we directly compared patterns plaque deposition glucose individuals....
Abstract The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss repetition and naming skills resulting from left posterior temporal inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted the disease (epicenters) investigate whether atrophy spreads through predetermined networks. First, used cross‐sectional structural MRI data individuals with lvPPA define...
Abstract Introduction One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define fluid biomarker characteristics early‐onset disease (EOAD). Methods Cerebrospinal (CSF) concentrations Aβ1‐40, Aβ1‐42, total tau (tTau), pTau181, VILIP‐1, SNAP‐25, neurogranin (Ng), neurofilament light chain (NfL), and YKL‐40 were measured by immunoassay in 165 LEADS participants. The associations with diagnostic group standard cognitive tests evaluated. Results Biomarkers correlated...
Abstract Approximately 5% of Alzheimer’s disease cases have an early age at onset (&lt;65 years), with 5–10% these attributed to dominantly inherited mutations and the remainder considered as sporadic. The extent which sporadic early-onset overlap is unknown. In this study, we explored clinical, cognitive biomarker profiles disease, focusing on commonalities distinctions between cases. Our analysis included 117 participants enrolled in Dominantly Inherited Alzheimer Network 118...
Tau PET has enabled the visualization of paired helical filaments 3 or 4 C-terminal repeat tau in Alzheimer disease (AD), but its ability to detect aggregated frontotemporal lobar degeneration (FTLD) spectrum disorders is uncertain. We investigated 2-(2-([<sup>18</sup>F]fluoro)pyridin-4-yl)-9<i>H</i>-pyrrolo[2,3-b:4,5c′]dipyridine ([<sup>18</sup>F]PI-2620), a newer tracer with ex vivo evidence for binding FTLD tau, convenience sample patients suspected and AD using static acquisition...
Stress and depression are increasingly recognized as cerebrovascular risk factors, including among high stress populations such people living with HIV infection (PLWH). may contribute to stroke through activation of neural inflammatory pathways. In this cross-sectional study, we examined the relationships between stress, systemic arterial inflammation, metabolic activity in stress-related brain regions on 18F-fluorodeoxyglucose (FDG)-PET PLWH. Participants were recruited from a parent trial...
Abstract Background Molecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated 18 F-MK-6240 tau PET as a biomarker for CTE. Two studies were done: (1) 3 H-MK-6240 autoradiography and an in-vitro brain homogenate binding on postmortem CTE tissue, (2) in-vivo study in former American football players. Methods Autoradiography done using frozen temporal frontal cortex tissue from six autopsy cases with stage III compared to Alzheimer’s disease. Thirty male National...
Abstract INTRODUCTION We examined sex effects on amyloid positron emission tomography (PET) in a large cohort of patients evaluated for cognitive complaints “real‐world” specialty setting. METHODS analyzed 10,361 PET scans (51% females) from the Imaging Dementia–Evidence Amyloid Scanning Study. positivity was defined by either local visual read or central processing and quantification (≥ 24.4 Centiloids). Sex differences were using multilinear regression logistic adjusted age, comorbidities,...
Abstract INTRODUCTION We used sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of pathologic burden in early‐onset Alzheimer's disease (EOAD). METHODS included baseline data from 77 cognitively normal (CN), 230 EOAD, 70 EO non‐Alzheimer's (EOnonAD) participants the Longitudinal Early‐Onset Disease Study (LEADS). stratified each diagnostic group by males females, then further subdivided APOE compared imaging biomarkers stratification. Voxel‐wise multiple linear regressions...
Objective We compared the accuracy of amyloid and [ 18 F]Flortaucipir (FTP) tau positron emission tomography (PET) visual reads for distinguishing patients with mild cognitive impairment (MCI) or dementia fluid biomarker support Alzheimer's disease (AD). Methods Participants FTP‐PET, amyloid‐PET, diagnosis dementia‐AD (n = 102), MCI‐AD 41), non‐AD diseases 76), controls 20) were included. AD status was determined independent PET by cerebrospinal plasma biomarkers. The mean age 66.9 years,...
In Alzheimer's disease (AD), the gradual accumulation of amyloid-β (Aβ) and tau proteins may underlie alterations in empathy. To assess whether aggregation medial temporal lobes related to differences cognitive empathy (the ability take others' perspectives) emotional experience feelings) AD. Older adults (n = 105) completed molecular Aβ positron emission tomography (PET) scans. Sixty-eight participants (35 women) were positive symptomatic with diagnoses mild impairment, dementia type,...
Abstract Background Amyloid‐PET quantification was developed in research settings using highly selected samples, harmonized acquisition protocols, and MRI‐based preprocessing. We aimed to analyze scans from IDEAS, a large‐scale, real‐world study of amyloid‐PET. Major challenges lie being acquired on various PET/PET‐CT/PET‐MR scanners without standardization or reconstruction MRI preprocess data. Method 18,295 Medicare beneficiaries with MCI dementia underwent PET [ 18 F]florbetapir,...