A5083724142- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Cerebrovascular and Carotid Artery Diseases
- Aortic aneurysm repair treatments
- Cardiovascular Health and Disease Prevention
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health Research Topics
- Acute Ischemic Stroke Management
- Biological Research and Disease Studies
- Surgical Sutures and Adhesives
- COVID-19 and Mental Health
- Meningioma and schwannoma management
- Blood Pressure and Hypertension Studies
- Action Observation and Synchronization
- Sarcoidosis and Beryllium Toxicity Research
- Genetic Associations and Epidemiology
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Neural and Behavioral Psychology Studies
- Medical Imaging Techniques and Applications
- Psychological Well-being and Life Satisfaction
Harvard University
2023-2025
University of Southern Indiana
2021-2025
Beth Israel Deaconess Medical Center
2024-2025
Massachusetts General Hospital
2025
Indiana University – Purdue University Indianapolis
2022-2023
Indiana University School of Medicine
2022-2023
Indiana University Bloomington
2022
Background Although previous studies have shown that cognitive decline in Alzheimer's disease (AD) is associated with various risk factors, they primarily focused on late-onset AD (LOAD). Objective We aim to evaluate the differential impact of factors between early-onset (EOAD, onset < 65 years) and LOAD (onset [Formula: see text] explore longitudinal effect Apolipoprotein E allele 4 ( APOE ε4) cortical atrophy both cohorts. Methods Using data from 212 EOAD 1101 participants Disease...
Abstract Background We studied the effect of apolipoprotein E ( APOE ) ε4 status and sex on age symptom onset (AO) in early‐ (EO) late‐ (LO) Alzheimer's disease (AD). Method A total 998 EOAD 2562 LOAD participants from National Coordinating Center (NACC) were included. used analysis variance to examine AO differences between sexes genotypes ε4, sex, their interaction LOAD, separately. Results carriers had younger older AO. Female compared non‐carriers P < 0.0001). There was no difference...
Social connectedness has been linked prospectively to cognitive aging, but there is little agreement about the social mechanisms driving this relationship. This study evaluated 9 measures of connectedness, focusing on 2 forms enrichment-access an expansive and diverse set loosely connected individuals (i.e., bridging) integration in a supportive network close ties bonding).This used egocentric data from 311 older adults Networks Alzheimer Disease study. Linear regressions were estimate...
Abstract Background We studied the effect of apolipoprotein E ( APOE ) ε4 status and sex on rates cognitive decline in early‐ (EO) late‐ (LO) onset Alzheimer's disease (AD). Method ran mixed‐effects models with longitudinal measures as dependent variables, sex, carrier status, interaction terms predictor variables 998 EOAD 2562 LOAD participants from National Coordinating Center. Results carriers showed accelerated relative to non‐carriers both LOAD, although patterns specific domains that...
Background: Chronic kidney disease (CKD) increases morbidity and mortality in most vascular procedures. However, a binary classification of estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m 2 , which is often used both modeling clinical trials, may not be optimal for predicting outcomes. Objective: Determine the eGFR cutoff use risk stratification prediction models. Methods: Vascular Quality Initiative (VQI) data non-emergent, first-time OAR, EVAR, TEVAR, CEA, CAS, PVI, Supra-...
Abstract INTRODUCTION We used sex and apolipoprotein E ε4 (APOE ε4) carrier status as predictors of pathologic burden in early‐onset Alzheimer's disease (EOAD). METHODS included baseline data from 77 cognitively normal (CN), 230 EOAD, 70 EO non‐Alzheimer's (EOnonAD) participants the Longitudinal Early‐Onset Disease Study (LEADS). stratified each diagnostic group by males females, then further subdivided APOE compared imaging biomarkers stratification. Voxel‐wise multiple linear regressions...
Abstract INTRODUCTION Social connectedness is associated with slower cognitive decline among older adults. Recent research suggests that distinct aspects of social networks may have differential effects on resilience, but few studies analyze brain structure. METHODS This study includes 117 cognitively impaired and 59 unimpaired The network characteristics (bridging/bonding) regions interests were analyzed using linear regressions voxel‐wise multiple gray matter density. RESULTS Increased...
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Abstract Background Social connectedness is associated with better cognitive performance among older adults. Previously, we found that bridging (access to an expansive network of diverse and loosely connected individuals) bonding (close supportive relationships familiar others) preserved gray matter density (GMD). We sought examine whether sex modulates these in the Networks Alzheimer’s Disease study (SNAD). Method analyzed baseline data 176 SNAD participants (58 male, 118 female; 117...
Abstract Background Social connectedness is associated with better cognitive performance among older adults. Previously, we found that bridging (access to an expansive network of diverse and loosely connected individuals) bonding (close supportive relationships familiar others) preserved gray matter density (GMD). We sought examine whether sex modulates these in the Networks Alzheimer’s Disease study (SNAD). Method analyzed baseline data 176 SNAD participants (58 male, 118 female; 117...