A5079024178- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Medical Imaging and Analysis
- Orthopaedic implants and arthroplasty
- Elasticity and Material Modeling
- Silk-based biomaterials and applications
- Knee injuries and reconstruction techniques
- Tendon Structure and Treatment
- Bone health and osteoporosis research
- Bone fractures and treatments
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Communication in Education and Healthcare
- Cell Adhesion Molecules Research
- Bone Tissue Engineering Materials
- Collagen: Extraction and Characterization
- Veterinary Orthopedics and Neurology
- Scoliosis diagnosis and treatment
- Orthopedic Surgery and Rehabilitation
- Periodontal Regeneration and Treatments
- Team Dynamics and Performance
- Total Knee Arthroplasty Outcomes
- Pelvic and Acetabular Injuries
University of California, San Francisco
2018-2025
University of California, Berkeley
2015-2025
Bioengineering Center
2023
Berkeley College
2023
Engineering (Italy)
2023
University of Pennsylvania
2006-2022
AO Foundation
2022
Tokai University
2022
Hellman Foundation
2017
Grace (United States)
2017
Measurement and normalization of disc geometry parameters for several animal models used in research.To compare normalized values to the human aid selection interpretation model studies.Animal are widely study intervertebral degeneration evaluate treatment methods because availability tissue, decreased variability between subjects compared with humans, feasibility perform vivo experiments. There is a general lack comparative data respect analog models.The height, lateral width, AP area,...
Hydrogels are useful materials as scaffolds for tissue engineering applications. Using hydrogels with additive manufacturing techniques has typically required the addition of such cross-linking or printing in sacrificial that negatively impact growth to remedy inconsistencies print fidelity. Thus, there is a need bioinks can directly cell-laden constructs. In this study, agarose-based commonly used cartilage were compared Pluronic, hydrogel established capabilities. Moreover, new material...
Abstract The primary function of the disc is mechanical; therefore, degenerative changes in mechanics and interactions between annulus fibrosus (AF) nucleus pulposus (NP) nondegenerate degenerate discs are important to functional evaluation. experiences complex loading conditions, including mechanical pressurized NP surrounding fiber‐reinforced AF. Our objective was noninvasively evaluate internal deformations human under axial compression with flexion, neutral, extension positions using...
Abstract Purpose The relationship between pain experience and biomechanical impairment in chronic low back (LBP) is unclear. Among the broader literature, sex-based differences have been established. However, it unknown if relates to compromised movement patterns for patients with LBP. This study examined sex whether there are associations function Methods To capture variability among LBP patients, we quantified full-body quality based on extent that 3D postural trajectories deviated from...
In Brief Study Design. Internal deformations and strains were measured within intact human motion segments. Objective. Quantify 2-dimensional internal deformation strain in compression of intervertebral discs using MRI. Summary Background Data. Experiments radiographic or optical imaging have provided important data for disc deformations. However, these studies are limited by physical markers and/or disruption the structural integrity. Methods. MR images acquired before during application a...
The highly organized structure and composition of the annulus fibrosus provides tissue with mechanical behaviors that include anisotropy nonlinearity. Mathematical models are necessary to interpret elucidate meaning directly measured properties understand structure-function relationships components, namely, fibers extrafibrillar matrix. This study as a combination strain energy functions describing fibers, matrix, their interactions. objective was quantify behavior both nondegenerate...
The intervertebral disk has an excellent swelling capacity to absorb water, which is thought be largely due the high proteoglycan composition. Injury, aging, degeneration, and diurnal loading are all noted by a significant decrease in water content tissue hydration. objective of this study was evaluate effect hydration, through osmotic loading, on compressive stiffness healthy disks. wet weight nucleus pulposus (NP) annulus fibrosus (AF) explants following 50% or greater, demonstrating...
Breathing involves fluid-solid interactions in the lung; however, lack of experimental data inhibits combining mechanics air flow to airway deformation, challenging understanding how biomaterial constituents contribute tissue response. As such, lung research is increasingly focused on exploring relationship between structure and function. To address these needs, we characterize mechanical properties porcine airways using uniaxial tensile experiments, accounting for bronchial orientation-...
ABSTRACT Understanding risk factors for delayed functional recovery following total hip arthroplasty (THA) is a critical gap in postoperative rehabilitation. The purpose of this study was to assess imaging associated with change biomechanical function THA. We hypothesized that muscle quality (as quantified by fat‐fraction) and arthritis (OA) severity, as determined from advanced magnetic resonance (MRI) sequences, would be recovery. Ten patients undergoing primary THA OA were prospectively...
Biomechanics of human intervertebral discs before and after nucleotomy.To noninvasively quantify the effect nucleotomy on internal strains under axial compression in flexion, neutral, extension positions, to determine whether change depended degeneration.Herniation may accelerate progression disc degeneration. Removal nucleus pulposus (NP) tissue has resulted altered mechanics vitro, including a decrease pressure an increase deformations at physiologically relevant strains. We recently...
Bioprinting is a growing field with significant potential for developing engineered tissues compositional and mechanical properties that recapitulate healthy native tissue. Much of the current research in tissue organ bioprinting has focused on complex require vascularization. Cartilage engineering been successful de novo using homogeneous scaffolds. However, as moves toward clinical application, cartilage will need to maintain nutrient diffusion larger scaffolds integrate surrounding...
This study investigated the potential use of synovium-derived stem cells (SDSCs) as a cell source for cartilage tissue engineering. Harvested SDSCs from juvenile bovine synovium were expanded in culture presence (primed) or absence (unprimed) growth factors (1 ng/mL transforming factor-β1, 10 platelet-derived factor-ββ, and 5 basic fibroblast factor-2) subsequently seeded into clinically relevant agarose hydrogel scaffolds. Constructs with factor-primed that received an additional transient...
Study Design. Disc recovery behavior under hypo- and hyperosmotic pressure. Objective. To evaluate the effect of osmotic pressure on unloaded response healthy discs. Summary Background Data. The intervertebral disc is a poroviscoelastic material that experiences large fluctuations in water composition throughout diurnal loading cycle. Fluid flow out occurs through mechanical loading, whereas fluid into passive diffusion because an imbalance ions between its surrounding environment. Osmotic...