A5035181181- Cannabis and Cannabinoid Research
- Glioma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Cancer-related cognitive impairment studies
- Family Support in Illness
- Radiomics and Machine Learning in Medical Imaging
- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Topic Modeling
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- DNA Repair Mechanisms
- Artificial Intelligence in Healthcare and Education
- Cancer survivorship and care
- Ginkgo biloba and Cashew Applications
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Ocular Oncology and Treatments
- Circular RNAs in diseases
- Biomedical Text Mining and Ontologies
- Chromatin Remodeling and Cancer
- RNA modifications and cancer
- Machine Learning in Healthcare
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
University of California, San Francisco
2019-2025
Neurological Surgery
2023-2025
City College of San Francisco
2024
Recent developments in large language models (LLMs) have unlocked opportunities for healthcare, from information synthesis to clinical decision support. These LLMs are not just capable of modeling language, but can also act as intelligent "agents" that interact with stakeholders open-ended conversations and even influence decision-making. Rather than relying on benchmarks measure a model's ability process data or answer standardized test questions, LLM agents be modeled high-fidelity...
Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among patients who did and not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to could personalize therapy improve outcomes.
Isocitrate dehydrogenase (IDH)-mutant astrocytomas represent the most frequent primary intraparenchymal brain tumor in young adults, which typically arise as low-grade neoplasms that often progress and transform to higher grade despite current therapeutic approaches. However, genetic alterations underlying high-grade transformation disease progression of IDH-mutant remain inadequately defined. Genomic profiling was performed on 205 from 172 patients both initial treatment-naive recurrent...
Background: Molecular biomarkers play a pivotal role in the diagnosis and treatment of oncologic diseases but staying updated with latest guidelines research can be challenging for healthcare professionals patients. Large Language Models (LLMs), such as MedPalm-2 GPT-4, have emerged potential tools to streamline biomedical information extraction, their ability summarize molecular disease subtyping remains unclear. Auto-generation clinical nomograms from text could illustrate new type utility...
Abstract BACKGROUND Caregivers of patients with primary brain tumors are at high risk for distress and as they navigate caring their loved one both a cancer diagnosis neurologic disorder. The last decade has seen growth caregiver research in the tumor community, evidence that mastery may correlate survival glioblastoma (GBM). UCSF Gordon Murray Neuro-Oncology Program, first its kind, launched 2014 mission to address unique needs. Caregiver care is now fully integrated into clinical UCSF,...
Abstract BACKGROUND Complex clinical decision-making in neuro-oncology is a multifaceted process involving numerous specialties influenced by various objective factors and patient preferences. Modeling these multidisciplinary discussions presents significant challenges, particularly given the multimodal nature of data. Recent advancements large language models (LLMs) have enabled development LLM “agents”. These agents pave way for multi-agent systems capable simulating interacting...
Abstract BACKGROUND Caregivers of patients with primary brain tumors are at high risk for distress as they navigate caring their loved one both a cancer diagnosis and neurologic disorder. The UCSF Gordon Murray Neuro-Oncology Program, the first its kind, addresses caregiver needs is fully integrated into clinical care, providing personalized care programming to address common challenges foster resilience. Program includes nurse, administrator, social worker. Referrals occur initial clinic...
Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year, 32% CNS malignant. Anecdotally, patients who report use cannabis, frequently describe higher quality life scores (QOL) in standardized instruments. However, the lack available tools that allow systematic documentation cannabis results a barrier accurately assess efficacy, potential benefits and risks. METHODS We conducted single center, observational study: with answered previously...
Abstract BACKGROUND Nearly 80,000 new cases of primary brain tumors are expected to be diagnosed this year in the United States: 32% CNS malignant. Anecdotally, patients who report use cannabis, frequently describe higher quality life scores (QOL) standardized instruments. However, lack available tools that allow systematic documentation cannabis results a barrier accurately assess efficacy and potential benefits risks. MATERIAL AND METHODS We conducted single center, observational study:...
2045 Background: Recurrence of GBM after initial treatment with surgery, radiation, and chemotherapy is nearly universal. Salvage therapies have limited efficacy median overall survival (OS) approximately 9 months 6-month-progression-free (PFS-6) 10-25% for both targeted traditional therapies. Given GBM’s molecular heterogeneity, targeting a single abnormality in isolation has consistently failed as strategy, precision combination approaches are needed. Methods: The primary objective was to...
Abstract BACKGROUND Gliomas are devastating primary tumors of the central nervous system that often present with difficult to manage symptoms in addition antineoplastic tumor itself. Due recent increase popularity and societal acceptance cannabis products, their use by glioma patients has increased. METHODS We conducted a single center, prospective study: answered locally validated survey inquire about at baseline every three months. Quality Life was measured using EORTC QLQ-C30, its...
Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These LLMs are not just capable of modeling language, but can also act as intelligent "agents" that interact with stakeholders open-ended conversations and even influence decision-making. Rather than relying on benchmarks measure a model's ability process data or answer standardized test questions, LLM agents should be assessed their...
Abstract Background Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among patients who did and not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to could personalize therapy improve outcomes. Methods We evaluated TMZ-related pathogenic SNPs genetically predicted transcript levels within 34 genes 1504 from the UCSF Adult Glioma Study...
Abstract Functional activation of the PI3K/AKT/mTOR pathway is seen in ~50% low-grade gliomas and correlates with worse survival. Everolimus a selective inhibitor mTOR that targets mTOR-raptor signaling, halting proliferation indirectly inhibiting angiogenesis. This phase 2 study evaluated efficacy everolimus untreated grade II diffuse glioma. Patients were stratified by 1p19q status PI3K (via phosphorylation PRAS-40) into three arms: 1) intact, PRAS-40 phosphorylated received monotherapy;...
Abstract Background There are ~3 million transposable elements in the human genome constituting about 42% of all basepairs. Retroelements (REs) ~90% present genome. Active REs considered highly mutagenic and have been implicated multiple steps cancer development progression, as well neurologic diseases. RE activity has functional effects on genome, including maintenance centromere telomere integrity, deleterious gene expression. Previous studies shown that certain families (HERVK, L1, Alu)...
Abstract BACKGROUND Epigenetic inhibition of the O6-methylguanine-DNA-methyltransferase (MGMT) gene has emerged as a clinically relevant prognostic marker in glioblastoma (GBM). Methylation MGMT promoter been shown to increase chemotherapy efficacy. While traditionally reported binary marker, recent methodological advancements have led quantitative approaches that measure methylation, providing clearer insights into methylation’s functional relationship with survival. METHODS A CLIA assay...