A5076569275- Herpesvirus Infections and Treatments
- Glioma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Genomics and Phylogenetic Studies
- Polyomavirus and related diseases
- Metabolomics and Mass Spectrometry Studies
- Astrophysical Phenomena and Observations
- DNA Repair Mechanisms
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Viral-associated cancers and disorders
- Astrophysics and Cosmic Phenomena
- Bacterial Identification and Susceptibility Testing
- Ferroptosis and cancer prognosis
- Pulsars and Gravitational Waves Research
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- melanin and skin pigmentation
- Genomic variations and chromosomal abnormalities
- Hematopoietic Stem Cell Transplantation
- Circular RNAs in diseases
- Advanced X-ray and CT Imaging
- Parvovirus B19 Infection Studies
Neurological Surgery
2020-2025
University of California, San Francisco
2020-2025
University of Nevada, Reno
2018-2020
University of California, Berkeley
2016-2019
University of Geneva
2007
Abstract Background Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the mechanisms of immune response to viral infection provides insight into disease etiology therapeutic opportunities. Methods We conducted comprehensive study including genome-wide transcriptome-wide association analyses identify loci associated with immunoglobulin G antibody 28 antigens 16 using serological data from 7924 European ancestry participants UK...
Context.In its first 4 years of observing the sky above 20 keV, INTEGRAL-ISGRI has detected 500 sources, around half which are new or unknown at these energies. Follow-up observations other wavelengths revealed that some sources feature unusually large column densities, long pulsations, and interesting characteristics.
ABSTRACT Introduction Humans and viruses have co-evolved for millennia resulting in a complex host genetic architecture. Understanding the mechanisms of immune response to viral infection provides insight into disease etiology therapeutic opportunities. Methods We conducted comprehensive study including genome-wide transcriptome-wide association analyses identify loci associated with immunoglobulin G antibody 28 antigens 16 using serological data from 7924 European ancestry participants UK...
Approximately 8% of the human genome is comprised endogenous retroviral insertions (ERVs) originating from historic integration into germ cells. The function ERVs as regulators gene expression well established. Less studied are insertional polymorphisms and their contribution to heritability complex phenotypes. most recent ERV, HERV-K, expressed in a range conditions cancer neurologic diseases. Using an in-house computational pipeline whole-genome sequencing data diverse 1,000 Genomes Phase...
Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among patients who did and not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to could personalize therapy improve outcomes.
Glioma is a highly fatal and heterogeneous brain tumor with few known risk factors. Our study examines genetically predicted variability in blood cell indices relation to glioma survival 3418 cases 8156 controls. We find that increased platelet lymphocyte ratio (PLR) confers an of (odds (OR) = 1.25, p 0.005), especially tumors isocitrate dehydrogenase (IDH) mutations (OR 1.38, 0.007) IDHmut 1p/19q intact (IDHmut-intact OR 1.53, 0.004) tumors. Genetically inferred counts lymphocytes 0.70,...
Aims.Active Galactic Nuclei are known to be variable throughout the electromagnetic spectrum. An energy domain poorly studied in this respect is hard X-ray range above 20 keV.
By circumventing the need for a pure colony, MALDI-TOF mass spectrometry of bacterial membrane glycolipids (lipid A) has potential to identify microbes more rapidly than protein-based methods. However, currently available bioinformatics algorithms (e.g., dot products) do not work well with glycolipid spectra such as those produced by lipid A, anchor lipopolysaccharide. To address this issue, we propose spectral library approach coupled machine learning technique accurately microbes. Here,...
Mass spectrometry-based proteomics facilitate disease understanding by providing protein abundance information about progression. For the same type of studies, multiple mass spectrometry datasets may be generated. Integrating can provide valuable that a single dataset analysis cannot provide. In this article, we introduce meta-analysis software, MetaMSD (Meta Analysis for Spectrometry Data) is specifically designed data. Using Stouffer’s or Pearson’s test, detects significantly more...
Rationale Polymicrobial samples present unique challenges for mass spectrometric identification. A recently developed glycolipid technology has the potential to accurately identify individual bacterial species from polymicrobial samples. In order develop and validate identification algorithms (e.g. machine learning) using this technology, generating a large number of various can be beneficial, but it is costly labor‐intensive. Here, we propose an alternative cost‐effective approach that...
Abstract Glioma is a highly fatal cancer with prognostically significant molecular subtypes and few known risk factors. Multiple studies have implicated infections in glioma susceptibility, but evidence remains inconsistent. Genetic variants the human leukocyte antigen (HLA) region modulate host response to infection been linked risk. In this study we leveraged genetic predictors of antibody 10 viral antigens investigate relationship survival. reactivity scores (GRS) for each were derived...
Journal Article Inherited polymorphisms in the Human Leukocyte Antigen Region modify association between varicella-zoster virus antibody reactivity and glioma prognosis Get access Stephen S Francis, Francis Department of Neurological Surgery, University California San Francisco, California, USADepartment Epidemiology Biostatistics, USAWeill Institute for Neurosciences, USA Corresponding Author: S. MS, PhD, Weill 1450 3rd St, CA 94158USA (Stephen.Francis@ucsf.edu)....
ABSTRACT Glioma is a highly fatal brain tumor comprised of molecular subtypes with distinct clinical trajectories. Observational studies have suggested that variability in immune response may play role glioma etiology. However, their findings been inconsistent and susceptible to reverse causation due treatment effects the immunosuppressive nature glioma. We applied genetic variants associated (p<5×10 −8 ) blood cell traits meta-analysis 3418 cases 8156 controls. Genetically predicted...
Abstract Background Temozolomide (TMZ) treatment has demonstrated, but variable, impact on glioma prognosis. This study examines associations of survival with DNA repair gene germline polymorphisms among patients who did and not have TMZ treatment. Identifying genetic markers which sensitize tumor cells to could personalize therapy improve outcomes. Methods We evaluated TMZ-related pathogenic SNPs genetically predicted transcript levels within 34 genes 1504 from the UCSF Adult Glioma Study...
Abstract Background There are ~3 million transposable elements in the human genome constituting about 42% of all basepairs. Retroelements (REs) ~90% present genome. Active REs considered highly mutagenic and have been implicated multiple steps cancer development progression, as well neurologic diseases. RE activity has functional effects on genome, including maintenance centromere telomere integrity, deleterious gene expression. Previous studies shown that certain families (HERVK, L1, Alu)...
Zusammenfassung Bei 31 Patientinnen mit mammographisch suspektem Befund wurden präoperativ beide Mammae emissionstomographisch (SPECT) untersucht. 30 und 120 Min. nach der Injektion von 370 MBq (10 mCi) 99mTcDTPA wurde jeweils eine Emissionstomographie durchgeführt. Die fokale Aktivitätsanreicherung in beiden den transversalen Rekonstruktionsschichten mittels ROI-Technik quantitativ analysiert. Sowohl benigne Veränderungen (n = 12) als auch Karzinome 19) speicherten vermehrt 99mTc-DTPA im...