A5100639683- Circular RNAs in diseases
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- CAR-T cell therapy research
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Genomics and Phylogenetic Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- Viral Infections and Immunology Research
- Sarcoma Diagnosis and Treatment
- Identification and Quantification in Food
- Pharmacological Effects of Natural Compounds
- Neonatal and fetal brain pathology
- Apelin-related biomedical research
- RNA regulation and disease
- Genetic and phenotypic traits in livestock
- Food Quality and Safety Studies
- Genetic Mapping and Diversity in Plants and Animals
- Neuroblastoma Research and Treatments
- Immune cells in cancer
- RNA modifications and cancer
- Biopolymer Synthesis and Applications
- Traditional Chinese Medicine Analysis
Shanghai First People's Hospital
2023-2024
Shanghai Jiao Tong University
2023-2024
Shandong Provincial Hospital
2019-2024
Shandong University
2019-2024
University of California, San Francisco
2019-2024
China Academy of Chinese Medical Sciences
2020-2023
Tongji University
2023
Peking University
2023
Capital University
2023
Capital Medical University
2023
Non-small cell lung cancer (NSCLC) is the major type of malignancy with increasing incidence worldwide. Despite progression in diagnosis and management NSCLC, patients' survival rate still unfavorable. Accumulating data have shown that circular RNAs (circRNAs) act as key roles oncogenesis. In this project, circ_0026134 expression NSCLC tissue specimens cells was measured by RT-qPCR. The functional (cell growth, apoptosis, migration, invasion) were investigated gain loss-of-function assays....
Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal constitutes a major pathology associated SCI stroke and strongly correlates neurological outcomes. Biomarkers characterized by expression specific induction post-injury likely to better correlate severity recovery, demonstrating higher...
Abstract Myocarditis (MC) is a common, potentially life-threatening inflammatory disease of the myocardium. A growing body evidence has shown that mitogen-activated protein kinase 14 (MAPK14) participates in pathogenesis MC. However, upstream regulators MAPK14 remain enigmatic. Circular RNAs (circRNAs) have been identified to play vital roles pathophysiology cardiovascular diseases. Nevertheless, clinical significance, biological function, and regulatory mechanisms circRNAs MC poorly...
Abstract Osteosarcoma (OS) exhibit intra- and inter-heterogeneity, complicating the exploration of effective therapeutic strategies. Traditional in vitro vivo models are limited inheriting biological genomic heterogeneities OS patients, even features on tumor microenvironment. The prolonged generation time current makes drug development slow is not suitable to clinically rapid timing. Here, we introduce methods for generating biobanking patient/PDX-derived osteosarcoma organoids (OS PD(X)Os)...
With the rapid development of sequencing technologies, characteristics and functions circular RNAs (circRNAs) in different tissues, their underlying pathophysiological mechanisms, have been identified. circRNAs are significantly enriched brain continually expressed from embryonic stage to adult rats. Previous studies reported that certain differentially glioma regulate a number biological processes, such as cell proliferation, metastasis oncogenesis glioma. Furthermore, associated with tumor...
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Matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDI-MSI) is a novel technique for in-situ distribution of various substances in tissue without labeling. This increasingly applied to the study medicinal plants owing its high spatial resolution and potential analysis small molecules. In this study, structural information their fragmentation patterns midazole alkaloids(1,3-dibenzyl-4,5-dimethylimidazolium chloride 1,3-dibenzyl-2,4,5-trimethylimi-dazolium chloride)...
A genetic examination using 14 structural loci and 7 microsatellite markers was carried out among random samples of Hu sheep (Hu), Tong (Tong) Yantse River Delta White goat (YRD); The mean heterozygosity (H), polymorphism information contents (PIC) effective numbers alleles (Ne) calculated based on the data from above two types were compared.The standard distances three populations gene frequencies results show that are greater than those loci.The are: 0.0268-0.2487, 0.2321-1.2313.The study...
Circular RNAs (circRNAs) have emerged as essential regulators and biomarkers in various diseases. To assess the different expression levels of circRNAs pediatric dilated cardiomyopathy (PDCM) explore their biological mechanistic significance, we used RNA microarrays to identify differentially expressed between three children diagnosed with PDCM healthy age-matched volunteers. The function was assessed a circRNA–microRNA (miRNA)–mRNA interaction network constructed from Gene Ontology Kyoto...
Abstract Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) vascular aberrations in TME. TME reprogramming a promising therapeutic approach for treating tumors. Anti-angiogenesis has power to control polarization of macrophages, prevent progression, increase drug penetration. Additionally, polyamine blocking therapy can CD8 + T...