A5100588324- Viral Infections and Immunology Research
- Human Pose and Action Recognition
- 3D Shape Modeling and Analysis
- Acupuncture Treatment Research Studies
- Cancer-related molecular mechanisms research
- Human Motion and Animation
- Immune cells in cancer
- Vagus Nerve Stimulation Research
- CAR-T cell therapy research
- Viral gastroenteritis research and epidemiology
- Sarcoma Diagnosis and Treatment
- Computational Geometry and Mesh Generation
- Inorganic Chemistry and Materials
- Genetic Associations and Epidemiology
- Glycosylation and Glycoproteins Research
- COVID-19 and Mental Health
- Asthma and respiratory diseases
- Neurological Complications and Syndromes
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Clostridium difficile and Clostridium perfringens research
- Circular RNAs in diseases
- Cognitive Functions and Memory
- Smoking Behavior and Cessation
- Reservoir Engineering and Simulation Methods
University of Chicago
2022-2025
Hebei University of Environmental Engineering
2025
Daqing Oilfield General Hospital
2023-2025
Shanghai Jiao Tong University
2023-2024
Huazhong Agricultural University
2024
Union Hospital
2024
Jilin University
2024
Shanghai First People's Hospital
2023-2024
Huanghuai University
2024
Chinese University of Hong Kong
2024
Abstract Background Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset (COA). However, the causal variants, regulatory elements, effector genes at these are largely unknown. Methods We performed heritability enrichment analysis to determine relevant cell types for AOA COA, respectively. Next, we fine-mapped putative variants COA loci. To improve resolution fine-mapping, integrated ATAC-seq data in blood lung...
Abstract Background Genome-wide association studies (GWAS) have identified hundreds of loci underlying adult-onset asthma (AOA) and childhood-onset (COA). However, the causal variants, regulatory elements, effector genes at these are largely unknown. Methods We performed heritability enrichment analysis to determine relevant cell types for AOA COA, respectively. Next, we fine-mapped putative variants COA loci. To improve resolution fine-mapping, integrated ATAC-seq data in blood lung...
While numerous hydrogel dressings are available for treating chronically infected wounds, their clinical application is impeded by intricate preparation processes, low mechanical strength, and frequent reliance on exogenous antimicrobial agents. The latter often leads to antibiotic misuse compromises the bioactivity of cell growth-promoting substances. Therefore, field therapeutic treatment faced with a pressing need prepare high-mechanical-strength hydrogels through facile procedure,...
Two-dimensional van der Waals heterostructures have good application prospects in solar energy conversion due to their excellent optoelectronic performance. In this work, the electronic structures of Sc2CF2/Sc2CCl2, Sc2CF2/Sc2CBr2, and Sc2CCl2/Sc2CBr2 heterostructures, as well properties photocatalysis photovoltaics, been comprehensively studied using first-principles method. Firstly, both three thermodynamically dynamically stable are found type-II band alignment with gap values 0.58 eV,...
Mastitis is a disease involved in inflammation of breast which affects human and animals. Wogonin one bioactive compound from many Chinese herbal medicines, have multiple properties, including anti-inflammatory activity. However, the roles wogonin mastitis progression are largely undefined. models were established using LPS-treated mice mammary epithelial cells (MECs). Infiltration inflammatory was analyzed by hematoxylin-eosin staining myeloperoxidase (MPO) Inflammatory cytokine (TNF-α...
Cancer has long been a topic of great interest in society and major factor affecting human health. Breast, prostate, lung, colorectal cancers are the top four tumor types with greatest incidence rates 2020, according to most recent data on global cancer incidence. Among these, lung had highest fatality rate. Extensive research shown that microRNAs, through different signaling pathways, play crucial roles development. It is considered PI3K/AKT pathway plays significant role development...
Abstract The functions of macrophages are governed by distinct polarization phenotypes, which can be categorized as either anti-tumor/M1 type or pro-tumor/M2 type. Glycosylation is known to play a crucial role in various cellular processes, but its influence on macrophage not well-studied. In this study, we observed significant decrease bisecting GlcNAc during M0-M1 polarization, and impaired was found drive polarization. Using glycoproteomics strategy, identified Lgals3bp specific...
Abstract Osteosarcoma (OS) exhibit intra- and inter-heterogeneity, complicating the exploration of effective therapeutic strategies. Traditional in vitro vivo models are limited inheriting biological genomic heterogeneities OS patients, even features on tumor microenvironment. The prolonged generation time current makes drug development slow is not suitable to clinically rapid timing. Here, we introduce methods for generating biobanking patient/PDX-derived osteosarcoma organoids (OS PD(X)Os)...
The activation of adenosine A1 receptors is important for protecting against ischemic brain injury and pretreatment with electroacupuncture has been shown to mitigate insult. aim this study was test whether the receptor mediates pretreatment-induced neuroprotection injury. We first performed 30 minutes at Baihui acupoint (GV20), delivered a current 1 mA, frequency 2/15 Hz, depth mm. High-performance liquid chromatography found that triphosphate levels peaked in cerebral cortex 15 120 after...
ObjectivesThis study was aimed at analyzing the burden and trend of Alzheimer's disease other dementias attributed to smoking (SADD) in Belt Road Initiative (BRI) countries during 1990–2019.MethodsData from The 2019 Global Burden Disease Study used extract information on SADD terms numbers age-standardized rate mortality (ASMR) disability-adjusted life years (ASDALR) BRI for 1990–2019. average annual percent change (AAPC) analyze temporal trends ASDALR 1990 final decade by Joinpoint...
Summary Background To investigate the impact of goggles on their health and clinical practice during management patients with COVID-19. Methods 231 nurse practitioners were enrolled who worked in isolation region designated hospitals to admit COVID-19 China. Demographic data, goggle-associated symptoms underlying reasons, incidence medical errors or exposures, effects fog all collected. Data stratified analyzed by age working experience. Risk factors multivariable logistical regression...
Objectives: Cerebral vasospasm (CVS) and early brain injury are major causes of morbidity mortality following subarachnoid hemorrhage (SAH). We investigated the efficiency human tissue kallikrein (HTK) to prevent CVS in a rabbit model SAH.Methods: Forty-eight Japanese white rabbits were randomly divided into four groups (n = 12 each): control (sham-operated), SAH, SAH + phosphate-buffered saline (PBS, vehicle), HTK. Basilar artery (BA) diameters measured by three-dimensional computed...
Orchids are often a mystery because of their close and complex relationships with various microorganisms in the natural environment. rely on to obtain nutrients, affecting seed germination, protocorm, adult plant growth. Currently, majority relevant research is concentrated isolating identifying environmental that support orchid development With metagenomic technology, our understanding mycorrhizal fungi (OMF) root-associated bacteria (RAB) has been expanded. New results discoveries have...
Abstract JOURNAL/nrgr/04.03/01300535-202407000-00042/figure1/v/2023-11-20T171125Z/r/image-tiff Elevated intraocular pressure (IOP) is one of the causes retinal ischemia/reperfusion injury, which results in NLRP3 inflammasome activation and leads to visual damage. Homer1a reported play a protective role neuroinflammation cerebrum. However, effects on inflammasomes injury caused by elevated IOP remain unknown. In our study, animal models were constructed using C57BL/6J Homer1 flox/ – /Homer1a...
Up to 20% of patients remain unsatisfied after total knee arthroplasty (TKA), prompting the development new implants. Bi-Cruciate Retaining (BCR) TKA preserves both anterior cruciate ligament (ACL) and posterior (PCL), with ACL beneficial for its proprioceptive qualities. The Stabilised (BCS) substitutes PCL a unique dual cam-post mechanism. Robotics improve accuracy facilitate technically demanding TKA.
The human norovirus (HuNov) major capsid VP1comprises an S (shell) and a P (protruding) domain; the latter is responsible for virus attachment infection. dimeric formation of (containing P1 P2 subdomains) indispensable forming receptor-binding pocket, enabling HuNov to dock factor histo-blood group antigens (HBGAs) on host cell. Thus, P-specific antibody may hamper engagement HBGA, thereby inhibiting In this study, we developed characterized two murine monoclonal antibodies (MAbs), namely,...
Abstract Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) vascular aberrations in TME. TME reprogramming a promising therapeutic approach for treating tumors. Anti-angiogenesis has power to control polarization of macrophages, prevent progression, increase drug penetration. Additionally, polyamine blocking therapy can CD8 + T...