A5024267736- Nerve injury and regeneration
- Spinal Cord Injury Research
- Stroke Rehabilitation and Recovery
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Mesenchymal stem cell research
- Zebrafish Biomedical Research Applications
- Muscle activation and electromyography studies
- Organ and Tissue Transplantation Research
- RNA regulation and disease
- Nerve Injury and Rehabilitation
- RNA Research and Splicing
- Trigeminal Neuralgia and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Medical Imaging and Analysis
- Viral Infections and Immunology Research
- Robot Manipulation and Learning
- Neurosurgical Procedures and Complications
University of Alberta
2014-2020
Women and Children’s Health Research Institute
2014-2018
MacEwan University
2015-2016
The reticulospinal tract (RtST) descends from the reticular formation and terminates in spinal cord. RtST drives initiation of locomotion postural control. axons form new contacts with propriospinal interneurons (PrINs) after incomplete cord injury (SCI); however, it is unclear if injured or uninjured make these connections. We completely transected all traced rats using a staggered model, where hemisection SCI at vertebra T10 followed by contralateral T7. In one group animals, T7 was...
Abstract We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT R) contributing post-SCI spasticity. Here we study and global gene expression using massively parallel sequencing. Evidence is presented the 5-HT R caused by down-regulation adenosine deaminase ADAR2 at least one other target, potassium channel Kv1.1, decreased after SCI. Bayesian network analysis genome-wide transcriptome data indicates (1) triggered persistent...
In this study, GFP+ skin-derived precursor Schwann cells (SKP-SCs) from adult rats were grafted into the injured spinal cord of immunosuppressed rats. Our goal was to improve cell survival in cord, which is typically low. Cells hyaluronan-methylcellulose hydrogel (HAMC) or modified with laminin- and fibronectin-derived peptide sequences (eHAMC). The criteria for selection hyaluronan its shear-thinning properties, making easy inject, methylcellulose inverse thermal gelation, helping keep...
An abstract is not available for this content. As you have access to content, full HTML content provided on page. A PDF of also in through the ‘Save PDF’ action button.