A5100747356- Animal Ecology and Behavior Studies
- Yersinia bacterium, plague, ectoparasites research
- Wildlife Ecology and Conservation
- Climate Change and Health Impacts
- Rhetoric and Communication Studies
- Viral Infections and Vectors
- Zoonotic diseases and public health
- Genetic Mapping and Diversity in Plants and Animals
- Leptospirosis research and findings
- Air Quality and Health Impacts
- Crop Yield and Soil Fertility
- Thermoregulation and physiological responses
- Microbial Community Ecology and Physiology
- Thermal Regulation in Medicine
- Inflammatory Bowel Disease
- Animal Behavior and Welfare Studies
- Genetics and Plant Breeding
- American Political and Social Dynamics
- Species Distribution and Climate Change
- Virus-based gene therapy research
- Rangeland and Wildlife Management
- Viral Infectious Diseases and Gene Expression in Insects
- Urban Heat Island Mitigation
- RNA Interference and Gene Delivery
- Bartonella species infections research
Ministry of Agriculture
2025
University of British Columbia
2017-2025
BC Centre for Disease Control
2022-2024
Northwestern University
2023
University of Saskatchewan
2019-2022
Ministry of Agriculture Livestock and Fisheries
2018-2022
Canadian Science Centre for Human and Animal Health
2021
Rothamsted Research
2021
University of Chicago
2019-2021
McMaster University
2021
With rapid advances in understanding molecular pathogenesis of human diseases the era genome sciences and systems biology, it is anticipated that increasing numbers therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold great promise to revolutionize clinical management diseases. It wildly recognized poor delivery limiting factor most vivo There has been a long-lasting interest using viral...
The transcription factor Sox9 was first discovered in patients with campomelic dysplasia, a haploinsufficiency disorder skeletal deformities caused by dysregulation of expression during chondrogenesis. Since then, its role as cell fate determiner embryonic development has been well characterized; differentiates cells derived from all three germ layers into large variety specialized tissues and organs. However, recent data shown that ectoderm- endoderm-derived continue to express mature...
British Columbia, Canada, was impacted by a record-setting heat dome in early summer 2021. Most households greater Vancouver do not have air conditioning, and there 440% increase community deaths during the event. Readily available data were analyzed to inform modifications public health response subsequent events 2021 guide further research.
Spontaneous remyelination occurs after spinal cord injury (SCI), but the extent of myelin repair and identity cells responsible remain incompletely understood contentious. We assessed cellular origin new by fate mapping platelet-derived growth factor receptor α (PDGFRα), Olig2+, P0+ following contusion SCI in mice. Oligodendrocyte precursor (OPCs; PDGFRα+) produced oligodendrocytes for <i>de novo</i> ensheathment ∼30% myelinated axons at epicenter 3 months SCI, demonstrating that these...
Abstract Western North America experienced an unprecedented extreme heat event (EHE) in 2021, characterized by high temperatures and reduced air quality. There were approximately 740 excess deaths during the EHE province of British Columbia, making it one deadliest weather events Canadian history. It is important to understand who at risk death EHEs so that appropriate public health interventions can be developed. This study compares 1,614 from 25 June 02 July 2021 with 6,524 on same dates...
This essay argues that a sustained form can be located in the complicated history of populist rhetoric. Despite its chameleonic qualities, advancement populism is constituted by alterations focus and content, not structure, activism. or what I term argumentative frame, positions virtuous people against powerful enemy expresses disdain toward traditional forms democratic deliberation republican representation. trace these themes through rhetoric People's Party, Huey Long, George Wallace....
While recombinant adenoviruses are among the most widely-used gene delivery vectors and usually propagated in HEK-293 cells, generating remains time-consuming labor-intense. We sought to develop a rapid adenovirus production amplification (RAPA) line by assessing human Ad5 genes (E1A, E1B19K/55K, pTP, DBP, DNA Pol) OCT1 for their contributions production.Stable transgene expression 293T cells was accomplished using piggyBac system. Transgene determined qPCR. Adenoviral assessed with...
Deep-sowing is an effective measure to ensure seeds absorbing water from deep soil layer and emerging normally in arid semiarid regions. However, existing varieties demonstrate poor germination ability some key quantitative trait loci (QTL) or genes related deep-sowing remain be identified analyzed. In this study, a high-resolution genetic map based on 280 lines of the intermated B73×Mo17 (IBM) Syn10 doubled haploid (DH) population which comprised 6618 bin markers was used for QTL analysis...
Antarctic terrestrial biodiversity faces multiple threats, from invasive species to climate change. Yet no large-scale assessments of threat management strategies exist. Applying a structured participatory approach, we demonstrate that existing conservation efforts are insufficient in changing world, estimating 65% (at best 37%, at worst 97%) native taxa and land-associated seabirds likely decline by 2100 under current trajectories. Emperor penguins identified as the most vulnerable taxon,...
Hepatitis E virus (HEV) is a globally distributed pathogen that causes acute hepatitis in people. Recent human cases of HEV arising after contact with urban rats (Rattus spp.) have raised concerns regarding whether may be source infection. We investigated Norway norvegicus) could an underserved neighborhood Vancouver, Canada. found 15% tested positive for rat HEV, and status was associated increasing body length family relationships. Rat isolates were clustered according to their location on...
Five species of fossil dicotyledonous wood are described from an Upper Cretaceous (Maestrichtian; locality in Alexander County, IllinoiS. U.S. A.Paraquercimum cretaceum has structure similar to the Fagaceae (evergreen Oak-Lithocarpus) and Casuarinaceae represents earliest known occurrence this structural type (large solitary pores uniseriate large multiseriale rays).Paraphyltanthoxyhin illirioisense Icacinoxylon alternipunctata genera represented at other Early Tertiary localities In...
Abstract The cranial suture complex is a heterogeneous tissue consisting of osteogenic progenitor cells and mesenchymal stem ( MSC s) from bone marrow mesenchyme. fusion sutures highly coordinated tightly regulated process during development. Craniosynostosis congenital malformation caused by premature sutures. While the derived should prove valuable for studying molecular mechanisms underlying development pathogenic fusion, primary human progenitors (SuPs) have limited life span gradually...
We found that lethal, urban rat control is associated with a significant increase in the odds surviving rats carry Leptospira interrogans. Our results suggest human interventions have potential to affect and even prevalence of zoonotic pathogens within populations.
Abstract— A method consist of co-crystallization, agglomeration, drying has been applied to develop a powder drink from butterfly pea flower (Clitoria ternatea) extract. The extract was concentrated by vacuum evaporation and incorporated with supersaturated sugar solution (more than 90 Brix), agglomerated dried at 60oC for 12 hours. anthocyanin stability antioxidant activity the evaluated 28 days three levels temperature (room temperature, 40oC, 50oC). decreased as increase storage...
To sustainably control urban rat infestations, management efforts need to encompass large areas of centers. Therefore, the objective this review and narrative synthesis was collate what is known about municipal-scale management. We explored frameworks that have been used at a scale in cities we describe expectations experts who designed implemented these frameworks. found there has persistent “war on rats” paradigm driving literature since early 1900s. Not only little quantitative evidence...
Visual systems of primates are the gold standard robust perception. There is thus a general belief that mimicking neural representations underlie those will yield artificial visual adversarially robust. In this work, we develop method for performing adversarial attacks directly on primate brain activity. We then leverage to demonstrate above-mentioned might not be well founded. Specifically, report biological neurons make up exhibit susceptibility perturbations comparable in magnitude...
Abstract The health risks associated with wildfires are expected to increase due climate change. Children susceptible wildfire smoke, but little is known about indoor smoke exposure at childcare facilities. objective of this analysis was estimate the effects outdoor PM 2.5 and episodes on facilities across British Columbia, Canada. We installed low-cost air-quality sensors inside outside 45 focused our operational hours (Monday–Friday, 08:00–18:00) during 2022 season (01 August–31 October)....