A5049381030- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Immune cells in cancer
- Rheumatoid Arthritis Research and Therapies
- Signaling Pathways in Disease
- Helicobacter pylori-related gastroenterology studies
- Systemic Lupus Erythematosus Research
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Sperm and Testicular Function
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Autophagy in Disease and Therapy
Ministry of Education of the People's Republic of China
2018-2025
Anhui Medical University
2018-2025
Chinese University of Hong Kong, Shenzhen
2025
China Pharmaceutical University
2012-2024
Shenzhen Second People's Hospital
2020-2022
Shenzhen University Health Science Center
2020-2022
Chinese University of Hong Kong
2003-2020
Shandong University
2015-2019
Jinan University
2018
Guangzhou Institutes of Biomedicine and Health
2018
To uncover the function and underlying mechanism of an essential transcriptional factor, PU.1, in development rheumatoid arthritis (RA).The expression localisation PU.1 its potential target, FMS-like tyrosine kinase 3 (FLT3), synovium patients with RA were determined by western blot immunohistochemical (IHC) staining. UREΔ (with knockdown) FLT3-ITD FLT3 activation) mice used to establish collagen antibody-induced (CAIA). For vitro study, effects on primary macrophages fibroblast-like...
Abstract Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the CAR-T cell infiltration into and inactivation of cells by immunosuppressive tumor microenvironment. Macrophage is an important component innate adaptive immunity, its unique phagocytic function been explored construct CAR macrophages (CAR-Ms) against tumors. This study aimed investigate application CAR-Ms in ovarian cancer. Methods In this study, we constructed...
The regulatory role of long noncoding RNAs (lncRNAs) have been partially proved in embryonic stem cells (ESCs) and induced pluripotent (iPSCs).In the current study, we investigated mouse ESC (mESC) self-renewal, differentiation, proliferation vitro by knocking down a lncRNA, growth arrest specific 5 (Gas5). A series related indicators were examined cell counting kit-8 (CCK-8) assay, quantitative reverse-transcription polymerase chain reaction (qRT-PCR), Western blot, alkaline phosphatase...
The ontogeny of macrophages in most organ/tissues human body has been proven. Due to the limited number and inaccessibility synovial (SM), origin SM not fully illuminated. objective this study was designed investigate evaluate role from different origins arthritis. Two SM, embryonic (ESM) bone marrow (BMSM) were identified Cx3cr1-EGFP mice, CCR2-/- mice (BM) chimera model by using a stringent sorting strategy. cellular features, including dynamic total cell number, situ proliferation,...
The specific role of fibroblast-like synoviocytes (FLSs) in the pathogenesis rheumatoid arthritis (RA) is still not fully elucidated. This study aimed to explore molecular mechanisms epigenetic pathways, including three factors, microRNA (miRNA)-22 (MIR22), ten-eleven translocation methylcytosine dioxygenase 3 (TET3), and MT-RNR2 like 2 (MTRNR2L2), RA-FLSs.
PDE4D has been reported to exhibit significantly elevated levels in the synovium of RA patients compared with OA, yet its role remains underexplored. This study aimed elucidate GRK2-PDE4D axis FLSs and explore potential as a therapeutic target for RA. Abundant expression both GRK2 was observed synovial tissues from experimental arthritis animals patients, synchronized noted patients. Global deletion Pde4d reduced disease incidence alleviated CIA mice. TNF-α upregulated expression, causing...
Neonatal germ cell development provides the foundation of spermatogenesis. However, a systematic understanding this process is still limited. To resolve cellular and molecular heterogeneity in process, we profiled single transcriptomes undifferentiated cells from neonatal mouse testes employed unbiased clustering pseudotime ordering analysis to assign distinct states developmental continuum. We defined unique transcriptional programs underlying migratory capacity, resting apoptosis...
The tumor-suppressor role of long noncoding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) has been proven in various types cancer. However, the specific function GAS5 tumor-associated macrophages (TAMs) endometrial cancer (EC) is elusive. Quantitative PCR results showed that expression decreased EC tissues and primary TAMs from tumors. Tumor-associated macrophage infiltration was significantly positively associated with developmental stage EC. Direct coculture GAS5-overexpressing...