A5083609983- Extracellular vesicles in disease
- Immune cells in cancer
- MicroRNA in disease regulation
- Topic Modeling
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Advanced Text Analysis Techniques
- Data Quality and Management
- CAR-T cell therapy research
First Affiliated Hospital Zhejiang University
2025
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Beijing Institute of Technology
2023
Shenzhen University Health Science Center
2022-2023
Shenzhen Second People's Hospital
2022
Abstract Background The chimeric antigen receptor (CAR)-T therapy has a limited therapeutic effect on solid tumors owing to the CAR-T cell infiltration into and inactivation of cells by immunosuppressive tumor microenvironment. Macrophage is an important component innate adaptive immunity, its unique phagocytic function been explored construct CAR macrophages (CAR-Ms) against tumors. This study aimed investigate application CAR-Ms in ovarian cancer. Methods In this study, we constructed...
Abstract The primary goal of treating malignant tumors is to efficiently eliminate the tumor and prevent metastasis recurrence. Unfortunately, immunosuppressive microenvironment (TME) a significant obstacle effective oncotherapy. Herein, therapeutic strategy based on melittin (MLT) encapsulated in hyaluronic acid‐modified metal–organic frameworks (MOFs) pioneered, focusing safe delivery TME‐responsive release MLT reshaping TME simultaneously activating immune system eradicate cancerous...
Abstract Backgrounds Microfibril-associated protein 2 (MFAP2) is a presenting in the extracellular matrix that governs activity of microfibrils through its interaction with fibrillin. While involvement MFAP2 metabolic disorders has been documented, expression and prognostic significance triple-negative breast cancer (TNBC) remain unexplored. Methods We acquired datasets pertaining to (BC) from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) databases. Next, Venn diagram was used...