A5101675234- T-cell and B-cell Immunology
- Rheumatoid Arthritis Research and Therapies
- Chemokine receptors and signaling
- Receptor Mechanisms and Signaling
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Nuclear Receptors and Signaling
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Veterinary medicine and infectious diseases
- Toxin Mechanisms and Immunotoxins
- Apelin-related biomedical research
- Biological Activity of Diterpenoids and Biflavonoids
- Psoriasis: Treatment and Pathogenesis
- interferon and immune responses
- Fungal Plant Pathogen Control
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal Tumor Research and Treatment
Anhui Medical University
2011-2024
Ministry of Education of the People's Republic of China
2010-2021
The specific role of fibroblast-like synoviocytes (FLSs) in the pathogenesis rheumatoid arthritis (RA) is still not fully elucidated. This study aimed to explore molecular mechanisms epigenetic pathways, including three factors, microRNA (miRNA)-22 (MIR22), ten-eleven translocation methylcytosine dioxygenase 3 (TET3), and MT-RNR2 like 2 (MTRNR2L2), RA-FLSs.
To investigate the effects of TACI-Ig, a recombinant fusion protein that modulates B- and T-cell activation by binding neutralizing B-lymphocyte stimulator (BLyS) proliferation-inducing ligand (APRIL), in an established adjuvant-induced arthritis (AA) rat model.Rats with experimental were randomly separated into different groups then treated TACI-Ig (0.7, 2.1, 6.3 mg/kg), rhTNFR-Fc (2.8 MTX (0.5 mg/kg) or IgG-Fc (6.3 from Day 16 to 34 after immunization. Arthritis was evaluated hind paw...
Paeoniflorin-6ʹ-O-benzene sulfonate (CP-25) is a modified paeoniflorin, which the main bioactive component of total glucosides peony. This study evaluated anti-inflammatory and immunoregulatory effects CP-25 in mice with collagen-induced arthritis (CIA) potential mechanisms underlying these effects. After onset CIA, were given (17.5, 35, or 70 mg/kg) methotrexate (MTX, 2.0 mg/kg). The index, swollen joint count, spleen histopathology evaluated. T B cell subsets assayed using flow cytometry,...
Summary Transmembrane activator and calcium modulator cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds neutralizes both B lymphocyte stimulator (BLyS), cytokine shown to be key regulator of cell maturation, proliferation survival, proliferation-inducing (APRIL). Rat adjuvant arthritis (AA) an experimental animal model rheumatoid (RA), which mainly dependent on T cells neutrophil-mediated production. The purpose the present study was investigate...
T helper 9 (Th9) cells are recognised for their characteristic expression of the transcription factor PU.1 and production interleukin-9 (IL-9), which has been implicated in various autoimmune diseases. However, its precise relationship with rheumatoid arthritis (RA) pathogenesis needs to be further clarified.
Immunoglobulin D (IgD) is a surface immunoglobulin that expressed as either membrane IgD (mIgD) or secreted (sIgD). Researchers have shown sIgD often elevated in patients with autoimmune diseases. The possible roles of on the function peripheral blood mononuclear cells (PBMCs) rheumatoid arthritis (RA) are still unclear. In this study, we compared expression sIgD, mIgD and receptor (IgDR) RA healthy controls, investigated effect PBMCs. We found levels IgDR were significantly higher controls....
The study was promoted to probe into the effect of BLyS on activity peripheral B lymphocytes mediated by receptors in patients with systemic lupus erythematosus (SLE). Thirty new-onset having fulfilled American College Rheumatology (ACR) revised criteria for diagnosis SLE. Twenty age-matched healthy volunteers were recruited this study. Peripheral blood samples used analyze expression protein and related (BR3, TACI), detect cell subpopulations different phases. Clinical disease evaluated...
Objective To study the pharmacokinetics of iguratimod in rats. Methods The concentration iguratirnod samples was determined by HPLC method. pharmacokineties parameters were calculated with DAS softwrare. Results main normal group(6mg/kg) as follows:t1/2Ke: 3.56h, tpeak: 4.00h, Cmax : 8.87μg/ml, AUC0.24 74.76μg· ml-1·h-1. three model groups(3,6,12mg/kg) follows: t1/2Ke: 4.54,3.20,3.17h, tpcak:3.83,3.83,4.67h, Cmax:3.84, 8.31,12.69μg/ml, :40.21,76. 72,117.06μg·ml-1·h-1. Except and AUC, no...
Objective To evaluate the therapeutic effects of cross linked sodium hyaluronate acid(JZC11) on experimentally induced osteoarthritic changes in rabbit knee joint and its protective roles OA patients cartilage vitro.Methods Osteoarthritis(OA) rabbits were established by classic Hulth method The study groups was intra-articular injected with JZC11(1.3,2.1,2.9mg/kg,0.8ml,once) one model rabbit,and acid(HA,1.3mg/kg,once a week for 5 weeks)as control joint,too. In addition,the sham operation...
Background: CP-25 (paeoniflorin-6-O-benzene sulfonate, patent number in China, ZL201210030616.4) is a modified compound from paeoniflorin (Pae), the main bioactive components of total glucosides peony (TGP). In current study, we evaluated effect focused on T cell-dependent immune response and synoviocytes activation CIA mice, assayed beta 2-AR signaling cells to find potential mechanism which was responsible for anti-inflammatory immunoregulatory RA. Methods: Collagen type 2 used induce...
Objective To investigate the therapeutic and immunomodulatory effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on adjuvant arthritis(AA) rats. Methods Twenty-four male Sprague-Dawley(SD) rats were established with AA by complete Freund's method.They randomly divided into model group hUC-MSCs (2×106 cells/mL, 5×106 tail vein injection), Yisaipu (2.8mg/kg, subcutaneous 6 in each group.Another SD used as control group.After was established, body weight paw volume...