A5100338196- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Immune Response and Inflammation
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Drug Transport and Resistance Mechanisms
- Traditional Chinese Medicine Analysis
- Gout, Hyperuricemia, Uric Acid
- Stress Responses and Cortisol
- Acute Kidney Injury Research
- Bone Metabolism and Diseases
- Psoriasis: Treatment and Pathogenesis
- Nuclear Receptors and Signaling
- Renin-Angiotensin System Studies
- Steroid Chemistry and Biochemistry
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Infant Health and Development
Institute of Urban Environment
2025
Chinese Academy of Sciences
2025
Anhui Medical University
2015-2024
Ministry of Education of the People's Republic of China
2014-2024
Peking University
2013
Capital Medical University
2013
University of Hong Kong
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
China Pharmaceutical University
2013
Abstract Paeoniflorin-6′-O-benzene sulfonate (code: CP-25), a novel ester derivative of paeoniflorin (Pae), was evaluated in rats with adjuvant-induced arthritis (AA) to study its potential anti-arthritic activity. AA were treated CP-25 (25, 50, or 100 mg/kg) from days 17 29 after immunization. effectively reduced clinical and histopathological scores compared the groups. CP-25-treated exhibited decreases pro-inflammatory cytokines (IL-1β, IL-6, IL-17 TNF-α) coupled an increase...
The responses of the infant gut microbiota to infection significantly disrupt natural intrahost evolutionary processes microbiome. Here, we collected a 16-month longitudinal cohort microbiomes affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Then, developed multicriteria approach identify core interaction network driving community dynamics under environmental disturbances, which termed Conserved Variated Interaction Group (CVIgroup). CVIgroup showed significant...
Rheumatoid arthritis (RA) is characterized by the massive infiltration of various chronic inflammatory cells in synovia. In synovial fluid patients with RA, M1 macrophages are dominant among all subtypes macrophages, mechanisms polarization imbalance RA has not been fully illuminated. The prostaglandin E2 (PGE2) augments M2 part via cyclic adenosine monophosphate (cAMP)-cyclic AMP responsive element binding (CREB) signaling. However, previous study found constant stimulus PGE2 on...
Paeoniflorin-6ʹ-O-benzene sulfonate (CP-25) is a modified paeoniflorin, which the main bioactive component of total glucosides peony. This study evaluated anti-inflammatory and immunoregulatory effects CP-25 in mice with collagen-induced arthritis (CIA) potential mechanisms underlying these effects. After onset CIA, were given (17.5, 35, or 70 mg/kg) methotrexate (MTX, 2.0 mg/kg). The index, swollen joint count, spleen histopathology evaluated. T B cell subsets assayed using flow cytometry,...
Ginsenoside metabolite compound K (CK; 20-<i>O</i>-d-glucopyranosyl-20(<i>S</i>)-protopanaxadiol), a novel ginsenoside metabolite, belongs to the dammarane-type triterpene saponins, according its structure. The anti-inflammatory activity of CK has been identified in several studies. Our study demonstrated that exerted an effect collagen-induced arthritis (CIA) and adjuvant-induced animal models, this was due inhibition abnormal activation differentiation T cells. However, mechanism...
Objective: To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and partial mechanisms focused function immunocyte (B cell macrophage) effectors’ (fibroblast-like synoviocyte, FLS).Methods: Animals were divided randomly into nine groups including control, AA, CK (5, 10, 20, 40, 80, 160 mg/kg, i.g.), MTX (0.5 i.g.). The AA are evaluated by swelling paw, histopathology joint, inflammatory cytokine production in serum. further B cell,...
Compound K (CK, 20-O-d-glucopyranosyl-20(S)-protopanaxadiol), a novel ginsenoside metabolite, is structurally member of the dammarane-type triterpene saponins. Several studies have identified anti-inflammatory activity CK. Our previous study demonstrated that CK exerted its effect via inhibition abnormal activation and differentiation T cells. However, mechanism action on B cells remains unclear.The objective this to investigate underlying mechanisms CK's effects memory in setting...
Prostaglandin E2 (PGE2) has been shown to play an important role in tumor development and progression. PGE2 mediates its biological activity by binding any one of four prostanoid receptors (EP1 through EP4). The present study was designed determine the EP2 receptor during proliferation apoptosis human HepG2 SMMC-7721 hepatoma cell lines effect paeoniflorin, a monoterpene glycoside. cells determined methyl thiazolyl tetrazolium after exposure selective agonists butaprost paeoniflorin....
Deficiency of G protein-coupled receptor kinase 2 (GRK2) was found to protect mice from dextran sulfate sodium (DSS)-induced colitis. Paeoniflorin-6'-O-benzene sulfonate (CP-25) has been shown exert anti-inflammatory immune regulatory effects in animal models inflammatory autoimmune disease. This study aimed investigate the GRK2 pathogenesis ulcerative colitis (UC) and its on macrophage polarization, subtype regulation intestinal barrier function, therapeutic CP-25 with DSS-induced We...
Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory, and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination therapy for rheumatoid arthritis (RA).To evaluate the effects of CK MTX on anaemia anti-arthritis adjuvant-induced (AA) rats.AA was induced rats by Complete Freund's adjuvant, divided into five groups (n = 10): normal, AA, 80 mg/kg, (80 mg/kg combined with 0.5 MTX), mg/kg. From day 12, (once a 15 days) or every 3 days, times) were...
Aim: To investigate the effects and mechanism of Ginsenoside Compound K (GCK) on psoriasis, focusing glucocorticoid receptor (GR) in keratinocytes. Methods: An imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model was generated to evaluate anti-inflammatory effect GCK. Hematoxylin eosin (H&E) staining used assess skin pathological changes. Protein expression K17 p-p65 mice assayed by immunohistochemical. phosphorylation p65 IκB were Western blot. K1, K6, K10, K16, K17, GR blot...
Abstract Peoniflorin‐6′‐O‐benzene sulfonate (CP‐25) inhibited the activity of GRK2 to exert anti‐inflammatory and immunomodulatory effects. This study aimed investigate effect CP‐25 intestinal epithelial barrier mechanism. CaCO‐2 cell monolayer dextran sulfate salt (DSS)‐induced colitis mouse model was used evaluate function in vitro vivo, respectively. Results showed that prevented dysfunction NF‐κB p65 activation TNF‐α‐induced cells. The colon structure destroyed DSS‐induced mice improved...
Ginsenoside compound K (GCK) has a glucocorticoid (GC)-like structure and functions as an agonist of the receptor (GR), exerting anti-inflammatory effects without causing hyperglycemic adverse effects.
Ginsenoside metabolite compound K (CK, 20-O-D-glucopyranosyl-20(S)-protopanaxadiol), a novel ginsenoside metabolite, belongs to dammarane-type triterpene saponins according its structure. The anti-inflammatory activity of CK has been identified in several studies. Our previous study demonstrated that exerted effect on collagen-induced arthritis (CIA) and adjuvant-induced (AA) animal models, this was due inhibiting the abnormal activation differentiation T cells. recent showed inhibitory cell...