A5064628702- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Autoimmune and Inflammatory Disorders Research
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- interferon and immune responses
- Inflammasome and immune disorders
- Medicinal Plant Pharmacodynamics Research
- Signaling Pathways in Disease
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Glycosylation and Glycoproteins Research
- Endoplasmic Reticulum Stress and Disease
- Microbial Metabolic Engineering and Bioproduction
- Quinazolinone synthesis and applications
- Natural Products and Biological Research
Anhui University of Traditional Chinese Medicine
2019-2025
Nanjing University of Chinese Medicine
2024
Yunnan Academy of Agricultural Sciences
2024
Children's Hospital of Zhejiang University
2022-2023
Ministry of Education of the People's Republic of China
2013-2020
Anhui Medical University
2006-2019
Central University of Finance and Economics
2016
Shandong Management University
2014
Shandong University
2014
Anhui Xinhua University
2013-2014
Calreticulin (CRT) is a highly conserved and ubiquitously expressed Ca2+-binding protein in multicellular eukaryotes. CRT plays crucial role many cellular processes including Ca2+ storage release, synthesis, molecular chaperone activity. To elucidate the function of CRTs plant responses against drought, main abiotic stress limiting cereal crop production worldwide, full-length cDNA encoding calreticulin namely TaCRT was isolated from wheat (Triticum aestivum L.). The deduced amino acid...
Calreticulin (CRT) is a key Ca 2+ ‐binding protein mainly resident in the endoplasmic reticulum (ER), which highly conserved and extensively expressed all eukaryotic organisms investigated. The plays important roles variety of cellular processes including signaling folding. Although calreticulin has been well characterized mammalian systems, increased investigations have demonstrated that plant CRTs number specific properties different from their animal counterparts. Recent developments on...
Abstract Paeoniflorin-6′-O-benzene sulfonate (code: CP-25), a novel ester derivative of paeoniflorin (Pae), was evaluated in rats with adjuvant-induced arthritis (AA) to study its potential anti-arthritic activity. AA were treated CP-25 (25, 50, or 100 mg/kg) from days 17 29 after immunization. effectively reduced clinical and histopathological scores compared the groups. CP-25-treated exhibited decreases pro-inflammatory cytokines (IL-1β, IL-6, IL-17 TNF-α) coupled an increase...
Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classic traditional Chinese medicine prescription for treating cerebral ischemia. The purpose of this study was to investigate the effect TQHXD on intervening inflammatory response ischemic stroke by regulating intestinal flora and repairing barrier. A rat model ischemia established using middle artery occlusion (MCAO) behavioral scores were performed. Additionally, high throughput 16S ribosomal DNA (rDNA) sequence bacteria in fecal samples also...
CP-25 attenuates arthritis progression in animal models by inhibiting G protein-coupled receptor kinase 2 (GRK2) membrane expression. This study compared groups treated with high-dose methotrexate (MTX)/leflunomide (LEF) and combined low-dose MTX/LEF an adjuvant-induced (AA) rat model investigated possible mechanisms. AA was induced rats via complete Freund's adjuvant. Experimental were divided into a normal group; vehicle monotherapy groups, including (50 mg/kg), MTX (0.25, 0.5 LEF (5, 10...
Context Er Miao San (EMS) is a formulation that contains Atractylodis Rhizoma and Phellodendri Cortex in 1:1 ratio, commonly used to treat rheumatoid arthritis (RA) other inflammatory diseases.Objective We investigated the mechanism of action effects EMS on peritoneal macrophage differentiation rat model adjuvant (AA).Materials methods (3, 1.5 0.75 g/kg; once daily) methotrexate (0.5 mg/kg; every 3 days) were administered orally from days 21 35 after immunisation. Paw swelling index...
Ermiao San (EMS), a traditional Chinese medicine composed of Atractylodes macrocephala and Cortex Phellodendron, has demonstrated therapeutic efficacy in rheumatoid arthritis (RA). Studies suggest that EMS modulates dendritic cell (DC) maturation adjuvant (AA) rats, though the precise mechanisms remain unclear. Prostaglandin receptor 4 (EP4) is critical inflammation DC function, while cyclic adenosine monophosphate (cAMP) regulates cellular signaling, potentially influencing RA pathogenesis...
The damaging effect of hyperlipidaemia on testicular structure was determined, and the influence melatonin evaluated in damage related to hyperlipidaemia. Hyperlipidaemia induced ApoE-knockout C57BL/6J male mice fed with high-fat diet alone (group A), or B). Six ApoE wild-type were normal diet, served as controls. At end experimental period, ultrastructural observations showed dramatically histopathological alterations tissues group A. basement membranes seminiferous tubules partially...
Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity, specificity and predictive power for clinical application. Thus, it significant to explore new immune-related SLE diagnosis development.We obtained seven gene expression profile microarrays (GSE121239/11907/81622/65391/100163/45291/49454) from GEO database. First, differentially expressed genes (DEGs) were screened using...
Background:The metastasis of colorectal cancer (CRC) is one the significant barriers impeding its treated consequence and bring about high mortality, less surgical resection rate poor prognosis CRC patients.PSAT1 an enzyme involved in serine biosynthesis.The studies showed that PSAT1 plays part a crucial character regulation tumor metastasis.And Epithelial-Mesenchymal Transition (EMT) process cell reprogramming which epithelialcells obtain mesenchymal phenotypes.It course promoting...
Objective: To investigate the effects of ginsenoside metabolite compound K (CK) on adjuvant-induced arthritis (AA) rats and partial mechanisms focused function immunocyte (B cell macrophage) effectors’ (fibroblast-like synoviocyte, FLS).Methods: Animals were divided randomly into nine groups including control, AA, CK (5, 10, 20, 40, 80, 160 mg/kg, i.g.), MTX (0.5 i.g.). The AA are evaluated by swelling paw, histopathology joint, inflammatory cytokine production in serum. further B cell,...
Context Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in 1:1 weight ratio. EMS has been used to treat rheumatism China for many years.Objective To evaluate the anti-arthritic activity extract on adjuvant-induced arthritis (AA) Sprague-Dawley rats clarify its mechanisms action.Materials methods (0.75, 1.5 3 g/kg, once daily) was orally administered from day 18 after immunization 31. The effects AA were evaluated by...