A5032122289- Spectroscopy and Quantum Chemical Studies
- Advanced Chemical Physics Studies
- Molecular spectroscopy and chirality
- Atmospheric chemistry and aerosols
- Spectroscopy and Laser Applications
- Atmospheric Ozone and Climate
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Rheumatoid Arthritis Research and Therapies
- Molecular Spectroscopy and Structure
- Synthesis and Properties of Aromatic Compounds
- Photochemistry and Electron Transfer Studies
- T-cell and B-cell Immunology
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Catalysis and Oxidation Reactions
- Asymmetric Hydrogenation and Catalysis
- Quantum optics and atomic interactions
- Heat shock proteins research
- Catalytic C–H Functionalization Methods
- Traditional Chinese Medicine Analysis
- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Synthesis and Catalysis
- NF-κB Signaling Pathways
- Biochemical effects in animals
Anhui Medical University
2015-2024
Zigong First People's Hospital
2021
Hefei University
2015-2018
Ministry of Education of the People's Republic of China
2010-2014
Chinese Academy of Sciences
2008-2011
Beijing National Laboratory for Molecular Sciences
2011
State Key Laboratory for Structural Chemistry of Unstable and Stable Species
2008
University of Science and Technology of China
2004-2007
Anhui University of Traditional Chinese Medicine
2007
Hong Kong University of Science and Technology
2006
Developing of multifunctional nanoplateforms for simultaneous accurate cancer detection and target therapy is essential in treatment. Herein, we present a facile synthesis DOX/MNPs-FA nanocomposites high-performance MRI tumor-targeted drug delivery. In such core-shell structured nanocomposite, the high magnetism iron oxide core can be tuned achieved by controlling Zn2+ dopant amount, making them suitable as excellent contrasts T2-weighted MR imaging. The outer porous silica shell with large...
This work investigated the ability of melatonin to prevent oxidative damage in brain tissue induced by injection beta-amyloid peptide 25-35 (Abeta25-35) middle-aged rats. The Morris water maze was used evaluate cognitive function Thiobarbituric acid-reactive substances and antioxidative enzymes (superoxide dismutase glutathione peroxidase) activities were measured. It found that (20 microg) into rat hippocampus caused an increase latency (the time find platform), total swimming distance...
Summary Transmembrane activator and calcium modulator cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds neutralizes both B lymphocyte stimulator (BLyS), cytokine shown to be key regulator of cell maturation, proliferation survival, proliferation-inducing (APRIL). Rat adjuvant arthritis (AA) an experimental animal model rheumatoid (RA), which mainly dependent on T cells neutrophil-mediated production. The purpose the present study was investigate...
Total glucoside of paeony (TGP), extracted from the root Paeonia Lactiflora, has been known to show anti-inflammatory, anti-oxidative, hepato-protective and immuno-regulatory activities. The aim this present study was determine anti-tumor effect TGP against N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) in rats, find related mechanisms. Rat HCC model established by intragastrically administrating with DEN (8 mg/kg). We found number tumor nodules index liver spleen were...
Multifunctional Ag@Fe<sub>3</sub>O<sub>4</sub>–PEI nanoparticles have been developed for simultaneously capturing and photothermal killing bacteria in contaminated source.
PEI-MNPs were successfully fabricated, which showed higher bacterial capture ability than the triaminopropylalkoxysilane directly modified NH-MNPs at low concentration.
To gain an understanding of the mechanisms by which Leydig cell steroidogenic function degenerates with ageing, we explored gene expression in relation to antioxidation status and endoplasmic reticulum (ER) stress during ageing mice. Expression StAR, P450scc other enzymes decreased starting at middle age (12-month-old) compared that young control (3-month-old) The immunohistochemical staining intensity 3β-HSD for cells was significantly weaker aged (24-month-old) group than group. number...
SUMMARY The main pathological characteristics of hepatic fibrosis in schistosomiasis are the proliferation stellate cells (HSCs) and deposition collagen type I (Col I) III III). Transforming growth factor beta-1 (TGF-β1) plays an important role fibrosis. Paeoniflorin (PAE) has been reported to have immunoregulatory effects; however, mechanism its anti-hepatic S. japonicum not elucidated. In present study, we found that mouse peritoneal macrophages (PMφs) stimulated by soluble egg antigen...
The centrosymmetric benzene molecule has zero first-order electric dipole hyperpolarizability, which results in no sum-frequency vibrational spectroscopy (SFVS) signal at interfaces, but it shows very strong SFVS experimentally. We perform a theoretical study on its SFVS, is good agreement with the experimental results. Its mainly comes from interfacial quadrupole hyperpolarizability rather than symmetry-breaking dipole, bulk quadrupole, and magnetic hyperpolarizabilities, provides novel...
The detailed potential energy surfaces for the reactions of Criegee intermediate (CI, H2COO) and formaldehyde (H2CO) with ozone (O3) have been investigated at CCSD(T)/aug-cc-pVDZ//B3LYP/6-311++G(2d,2p) level theory, respectively. New alternative reaction mechanisms, to one previously proposed (J. Phys. Chem. Lett. 2013, 4, 2525) found. lower barrier new mechanism shows that it is easy H2COO + O3 dissociate oxygen. For H2CO produce O2, we find relatively high barriers, which makes...
By combining molecular dynamics (MD) simulation and density functional theory (DFT) calculations, we investigate the surface doubly resonant sum-frequency vibrational spectroscopy (SFVS) for a monolayer of R-1,1′-bi-2-naphthol (R-BN) molecules on water surface. MD simulations indicate that R-BN stand perpendicularly due to hydrogen bonding with molecules. DFT time-dependent (TDDFT) methods are employed obtain potential energy shifts, transition dipoles, their derivatives, which then used...
Dendritic cells (DCs) are the most powerful antigen-presenting that have an important role in immunity and immune tolerance. Transforming growth factor β (TGF-β) is a pleiotropic cytokine widely expressing various tissues cells, which regulates cellular proliferation, differentiation apoptosis of several considered to be key inducing The effect TGF-β on DCs very complex. In this study, we further investigated tolerance DCs. were differentiated from mice bone marrow absence or presence TGF-β....
The doubly resonant IR-UV sum-frequency vibrational spectroscopy (SFVS) of 1,1'-bi-2-naphthol (BN) solution and its dispersion spectra are analyzed computed using the ZINDO//AM1 calculation direct approach Raman scattering tensor calculation, which is based on calculations Franck-Condon factors differentiation electronic transition moments with respect to normal modes. calculated results indicate that, for most intense bands observed in SFVS experiment, frequencies, symmetry, order,...
Magnetic-based nanomaterials are promising for cancer diagnosis and treatment. Herein, we develop a self-assembled approach the preparation of porous magnetic nanosystem, DOX/Mn(0.25)-Fe3O4-III NPs, which can simultaneously achieve chemotherapy, ferroptosis therapy MRI to improve therapeutic efficacy. By tuning its structures, whole particle sizes compositions, this nanosystem possesses both high drug loading capacity excellent Fenton reaction activity. Owing synergetic catalysis effect iron...