A5087651253- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Shoulder and Clavicle Injuries
- Spinal Hematomas and Complications
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Orthopedic Infections and Treatments
- Osteomyelitis and Bone Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Vascular Malformations Diagnosis and Treatment
- Pelvic and Acetabular Injuries
- Virus-based gene therapy research
- Medical Imaging and Analysis
- interferon and immune responses
- Autoimmune and Inflammatory Disorders Research
- Trauma Management and Diagnosis
- Intracranial Aneurysms: Treatment and Complications
- Viral Infections and Outbreaks Research
- Musculoskeletal pain and rehabilitation
Weifang Medical University
2019-2024
Shandong Agricultural University
2019
Anhui Medical University
2012
Memorial Hospital of South Bend
1990-1998
Chang Gung Memorial Hospital
1990-1995
Chang Gung University
1988
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a bunyavirus that causes SFTS, case fatality rate of up to 30 %. The innate immune system plays crucial role in the defense against SFTSV; however, impact viral propagation STFSV on remains unclear. Although proteomics analysis revealed expression downregulator transcription 1 (DR1) increased after SFTSV infection, specific change trend and functional DR1 during infection remain unelucidated. In this study, we demonstrate was...
Abstract The innate immune system provides a defense against invading pathogens by inducing various interferon (IFN)-stimulated genes (ISGs). We recently reported that tripartite motif protein 25 (TRIM25), an important ISG, was highly upregulated in duck embryo hepatocyte cells (DEFs) after infection with viral hepatitis A virus type 1 (DHAV-1). However, the mechanism of upregulation TRIM25 remains unknown. Here we interleukin-22 (IL-22), whose expression facilitated DEFs and organs...
Duck astrovirus type 1 (DAstV-1) infection constitutes a cause of viral hepatitis in ducklings and little is known about the B-cell epitope DAstV-1. In this study, monoclonal antibody (mAb) 3D2 against open reading frame 2 (ORF2) protein DAstV-1 was used to identify possible four serotypes DAstV. The mAb showed no neutralization activity DAstV-1, reacted with conserved linear epitopes 454STTESA459 ORF2 protein. Sequence analysis, dot blot assay, cross-reactivity test indicated that peptide...
Abstract The interaction between viral components and cellular proteins plays a crucial role in replication. In previous study, we showed that the 3′—untranslated region (3′—UTR) is an essential element for replication of duck hepatitis A virus type 1 (DHAV-1). However, underlying mechanism still unclear. To gain deeper understanding this mechanism, used RNA pull-down matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay to identify new host factors interact with...