A5020469958- Oral microbiology and periodontitis research
- Railway Engineering and Dynamics
- Salivary Gland Disorders and Functions
- Drug Transport and Resistance Mechanisms
- Sperm and Testicular Function
- Structural Engineering and Vibration Analysis
- Civil and Geotechnical Engineering Research
- Effects of Vibration on Health
- Assisted Reproductive Technology and Twin Pregnancy
- Fluid Dynamics and Vibration Analysis
- Vibration and Dynamic Analysis
- Advanced Drug Delivery Systems
- Geotechnical Engineering and Underground Structures
- Periodontal Regeneration and Treatments
- Immune cells in cancer
- RNA modifications and cancer
- Metabolism and Genetic Disorders
- Renal Diseases and Glomerulopathies
- Vehicle Dynamics and Control Systems
- Mitochondrial Function and Pathology
- Chronic Kidney Disease and Diabetes
- Immune Response and Inflammation
- Chemotherapy-induced organ toxicity mitigation
- Offshore Engineering and Technologies
- Gut microbiota and health
Anhui University of Traditional Chinese Medicine
2022-2025
Zhengzhou University
2007-2024
Third People's Hospital of Hefei
2024
Anhui Medical University
2024
The University of Texas at San Antonio
2009
Rutgers, The State University of New Jersey
2007
Rutgers New Jersey Medical School
2005-2007
East Orange VA Medical Center
2003
Shriners Hospitals for Children - Galveston
1999
The University of Texas Medical Branch at Galveston
1997-1998
Periodontitis is characterized by local inflammatory response and the resultant alveolar bone resorption. The elevated reactive oxygen species (ROS) level not only aggravates inflammation but also prohibits osteogenesis. Hence, simultaneously scavenging ROS triggering activity of osteoblasts may produce synergism in periodontium regeneration. Herein, we developed an injectable hydrogel system, CC-B-CAPE@CY-NPs, for periodontitis treatment, which caffeic acid phenethyl ester (CAPE), a...
Currently, the antibiotics-loaded hydrogels have not shown an over standard of clinical effects on periodontitis treatment. Abnormal crosstalk between macrophages and periodontal ligament stem cells (PDLSCs) is a key factor for unexpected efficacy. Here, we reported therapeutic strategy programmed intervention PDLSCs based folic acid-modified liposome hydrogel composites loaded with genistein (FA-GEN-Lip@Gel). FA-GEN-Lip@Gel exhibited excellent thermos-sensitivity injectability, could...
Propolis has a long ethnopharmacological history for oral periodontal diseases treatment. flavonoids are main active components anti-inflammation and tissue protection. However, the intractable dissolution properties of propolis complex environment pose great challenges delivery. In addition, therapeutic mechanism as well correlation inflammation resolution regeneration remain unclear flavonoids. this study, we constructed an in situ thermosensitive depot systems using total from...
P‐glycoprotein (Pgp) is a membrane‐transport ATPase. It uses energy from ATP hydrolysis to transport pleiotropic cytotoxic drugs inside outside of cells. Thus, elevated expression Pgp in cancer cells causes multidrug resistance. now known that the conformational state changes during its catalytic cycle. However, how relates drug binding by yet be determined. In this study, we used limited trypsin digestion isolated inside‐out membrane vesicles investigate effects on conformation and...
A satisfactory clinical effect in treating periodontitis is often difficult to achieve by conventional non-surgical systemic drug delivery due the narrow anatomical structure of periodontal pocket and insufficient concentration at lesion sites. In addition, feasibility combating tissue lesions restoring alveolar bone allowing collagen regeneration has not been fully explored. The objective this study was prepare a microemulsion integrating anti-inflammatory osteogenic active ingredients...
Abstract Periodontitis is a chronic inflammatory disease of tooth support tissues leading to progressive destruction periodontal soft as well alveolar bone, and can be treated with anti‐inflammatory bone‐protective agents prevent progression. Caffeic acid phenethyl ester (CAPE) natural polyphenolic compound anti‐inflammation, anti‐oxidation bone tissue repair efficacy. In this work, we synthesized thermosensitive hydrogel matrix acetylated carboxymethyl chitosan (A‐CC), firstly applied for...
In humans, cerebral hypoxia is a common component of severe brain insults, including trauma, stroke, and perinatal asphyxia. Oxidative stress free radicals incidental to are implicated in damaging macromolecules, leading collapse cellular homeostasis cell death. Neuronal DNA damage, as direct measurable event, has not been addressed hypoxia. Here, we measured hypoxia-induced damage repair nuclear mitochondrial rat hippocampus cortex. Two highly sensitive quantitative polymerase chain...
P-glycoprotein (Pgp) is a membrane protein that transports chemotherapeutic drugs, causing multidrug resistance in human cancer cells. Pgp member of the ATP-binding cassette superfamily and functions as transport ATPase. It has been suggested conformation changes catalytic cycle. In this study, we tested hypothesis by using limited proteolysis tool to detect different conformational states trapped binding nucleotide ligands inhibitors. high basal ATPase activity; is, ATP hydrolysis not...
P-glycoprotein (Pgp)1 is a polytopic membrane protein and functions as an energy-dependent drug efflux pump. It responsible for multidrug resistance (MDR) in cancer cell lines. Recently, the topological structure of Pgp has been investigated. However, results are dispute. A major question concerning topology orientation loop linking TM4 TM5 (loop 4) TM8 TM9 8). In this study, we generated polyclonal antibodies specific to these two loops. combination with panel other well-characterized...
Male infertility as a result of spinal cord injury (SCI) is associated with abnormal semen qualities including low sperm counts and poor motility morphology. Clinical studies suggest that reactive oxygen species (ROS)-related events might contribute to functions after SCI. The current study examined whether impaired SCI can be ameliorated by an antioxidant, vitamin E. Vitamin E feeding transected (SCX) rats during the acute (maintenance) chronic (restoration) phases partially preserved...
Nowadays, the comfort of drivers and passengers is drawing more attention. The interaction between vehicles asphalt road can cause coupled vibration reduce passengers. Therefore, research on human–vehicle–road great importance. In this paper, three-dimensional human–bus–road system established, including bus model, parallel biomechanical human model with 2 degrees-of-freedom (DOF), surface roughness condition. proposed was then used to study dynamic response evaluation body. evaluation,...
The study in this paper aims to evaluate the effects of vehicle‐bridge coupled vibration on vehicle ride comfort. mechanical model both and bridge subsystems differential equations are established, respectively, based principle dynamic balance finite element method. APDL command stream for iterative calculation is compiled ANSYS platform. method comfort established according criteria ISO2631‐1‐1997. responses analyzed considering different pavement levels while multiple vehicles pass through...
ABSTRACT: Our previous studies demonstrated various abnormalities in spermatogenesis after spinal cord injury (SCI) cord‐transected rats. In this study, we examined whether SCI rats were related to the degree of SCI. We used cordcontused (SCC) as a model. Adult male Sprague‐Dawley subjected degrees contusion caused by weight rod dropped from different heights (12.5, 25, 50, and 75 mm) using New York University IMPACTOR. Testicular histology revealed persistent complete all SCC 4, 8, or 14...
α-Melanocyte-stimulating hormone (α-MSH), an endogenous melanocortin peptide, has been demonstrated to have anti-inflammation effects and protect against cartilage damage. Objective In this study, we aimed investigate whether α-MSH in ankle joint synovial fluid is associated with the disease severity of posttraumatic osteoarthritis (PTAOA).66 PTAOA patients undergoing arthroscopical debridement or replacement were enrolled study. Synovial concentrations explored by a special radioimmunoassay...