A5101738673- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Lipid metabolism and disorders
- Psoriasis: Treatment and Pathogenesis
Ministry of Education of the People's Republic of China
2023-2024
Anhui Medical University
2023-2024
Aim: To investigate the effects and mechanism of Ginsenoside Compound K (GCK) on psoriasis, focusing glucocorticoid receptor (GR) in keratinocytes. Methods: An imiquimod (IMQ)-induced psoriasis-like dermatitis mouse model was generated to evaluate anti-inflammatory effect GCK. Hematoxylin eosin (H&E) staining used assess skin pathological changes. Protein expression K17 p-p65 mice assayed by immunohistochemical. phosphorylation p65 IκB were Western blot. K1, K6, K10, K16, K17, GR blot...
Ginsenoside compound K (GCK) has a glucocorticoid (GC)-like structure and functions as an agonist of the receptor (GR), exerting anti-inflammatory effects without causing hyperglycemic adverse effects.