A5008521420- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Neonatal and Maternal Infections
- Helicobacter pylori-related gastroenterology studies
- Pneumonia and Respiratory Infections
- Retinal Diseases and Treatments
- Urinary Tract Infections Management
- Neonatal and fetal brain pathology
- Retinopathy of Prematurity Studies
- Inflammatory Bowel Disease
- Bacterial Infections and Vaccines
- S100 Proteins and Annexins
- Barrier Structure and Function Studies
- Antibiotic Resistance in Bacteria
- Infant Nutrition and Health
Capital Institute of Pediatrics
2022-2025
Background Escherichia coli is one of the most common pathogens causing neonatal infections. Recently, incidence and drug resistance E. have increased, posing a major threat to health. The aim this study was describe analyze antibiotic multilocus sequence typing (MLST) characteristics derived from infants admitted intensive care units (NICUs) across China. Methods In study, 370 strains neonates were collected. isolated these specimens subjected antimicrobial susceptibility testing (by broth...
Abstract Background Neonatal bacterial meningitis is a common neonatal disease with high morbidity, and can cause serious sequelae when left untreated. Escherichia coli the pathogen, its endotoxin, lipopolysaccharide (LPS) damage endothelial cells, increasing permeability of blood-brain barrier (BBB), leading to intracranial inflammation. However, specific mechanism induced by LPS damaging BBB remains unclear. In this study, mouse brain microvascular (bEND.3) cells were used as research...
Necrotizing enterocolitis (NEC) is an acute intestine dysfunction intestinal disorder characterized by inflammation and cell death, including pyroptosis. Previous studies have implicated pyroptosis, particularly via NLRP3 inflammatory activation, contribute to the development of NEC. However, genetic molecular mechanisms underlying pyroptosis in NEC pathogenesis sequelae remain unclear. Our study aimed identify pyroptosis-related populations genes explore potential therapeutic targets....
Abstract Background Early identification of pathogenic bacteria and monitoring residual status are essential for accurate treatment neonatal bacterial meningitis (NBM). Methods Clinical data specimens were collected from neonates with NBM. Bacterial cultures RT‐PCR blood cerebrospinal fluid (CSF) compared to assess the positivity rate, sensitivity specificity each method. Results had a higher rate cultures, regardless whether antibiotics been used prior specimen collection. After 1 week...
Background: To investigate the changes and clinical significance of lymphocyte subsets in neonates with respiratory syncytial virus (RSV) pneumonia, levels cytokines IFN-γ IL-4 peripheral blood acute convalescent stages RSV pneumonia (the study group) were compared a control group.Methods: Twenty-three who met inclusion criteria selected as group, 20 convalescence simple neonatal hyperbilirubinemia same period group. Flow cytometry was used to detect proportion (CD3+, CD4+, CD8+, CD4+/CD8+,...