A5003008298- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- Bone health and treatments
- Diverse Aspects of Tourism Research
- Cancer-related gene regulation
- Cruise Tourism Development and Management
- Bone Metabolism and Diseases
- Economic Zones and Regional Development
- Mycobacterium research and diagnosis
- Collaboration in agile enterprises
- Innovation and Knowledge Management
- Corporate Insolvency and Governance
- Education, Law, and Society
- Extracellular vesicles in disease
- Cloud Data Security Solutions
- Legal principles and applications
- Immunotherapy and Immune Responses
- interferon and immune responses
- Flavonoids in Medical Research
- Circular RNAs in diseases
- Environmental and Agricultural Sciences
- Urban Green Space and Health
Soochow University
2012-2025
Tashkent State University of Economics
2023-2024
People's Liberation Army No. 150 Hospital
2020
Chinese People's Liberation Army
2020
Jining First People's Hospital
2019
First Affiliated Hospital of Soochow University
2018
Qingdao University
2018
Affiliated Hospital of Qingdao University
2018
Dalian Medical University
2015
Wuxi People's Hospital
2013
Enforced expression of miR-34a eliminates cancer stem cells in some malignant tumors. Sirtuin-1 (SIRT1) is a direct target miR-34a. Here we found low levels and high SIRT1 CD44+/CD24- breast (BCSCs). MiR-34a overexpression knockdown decreased proportion BSCSs mammosphere formation. Expression CSC markers, ALDH1, BMI1 Nanog was decreased. In nude mice xenografts, stable silencing reduced tumor burden. Taken together, our results demonstrated that inhibits proliferative potential BCSCs vitro...
Studies already revealed that some E3 ubiquitin ligases participated in the immune response after viral infection by regulating type I interferon (IFN) pathway. Here, we demonstrated signaling enhanced translocation of ETS1 to nucleus and promoter activity ligase DTX3L (deltex 3L) virus thus increased expression DTX3L. Further experiments suggested ubiquitinated TBK1 at K30 K401 sites on K63-linked ubiquitination was also necessary for mediating phosphorylation through binding with tyrosine...
E3 ubiquitin ligases are key molecules in regulating the innate immune responses against virus. They catalyze activation or degradation of various signaling proteins involved responses. Herein, we found regulatory role RNF149 host's viral infection. Virus infection induced expression RNF149. Overexpression was associated with reduced production IFN-β and enhanced replication. Mechanically, interacted IRF3 downregulated its protein level. As an ligase, promoted K27-linked ubiquitination at...
The Casitas B-lineage lymphoma (Cbl) family proteins are E3 ubiquitin ligases implicated in the regulation of various immune cells. However, their function dendritic cells (DCs) remains unclear. To investigate role Cbl members DCs, we created cell double-deficient B lymphoma-b (Cbl-b) and lineage (c-Cbl) mice by crossing Cbl-b-/- with c-Cblflox/flox CD11c-Cre+ mice. We found that specific deletion Cbl-b c-Cbl CD11c+ cells, predominantly led to liver fibrosis, cirrhosis, accumulation systemic...
Abstract Long non-coding RNAs (lncRNAs) play a crucial role in macrophage development but little is known about their asthma. Here, we investigated the of lncRNA lncTRPM2-AS asthma and found that participates promotion inflammation. Downregulation promoted apoptosis inhibited proliferation production cytokines including IL-1β, IL-4, IL-6, IL-10, TNF-α, TGF-β. RNA-immunoprecipitation mass spectrometry indicated protein TRPM2 interacted with both E3 ubiquitin ligase TRIM21. LncTRPM2-AS...
As a subtype of non-small-cell lung cancer, squamous cell carcinoma (LUSC) accounts for one-fifth all cancers. Unfortunately, no specific targetable aberration has yet been identified. Hence, it is huge urgency and potential to identify aberrantly regulated genes in LUSC. Here, five pairs LUSC samples their corresponding adjacent tissues were subject whole transcriptome sequencing. Our results showed that CTD-2562J17.6 FENDRR significantly downregulated while MIR205HG, LNC_000378,...
BACKGROUND MicroRNAs (miRNAs) have emerged as central regulators of many processes. MiRNA-34 (miR-34) functions a well-known tumor suppressor. The aim this study was to investigate the mechanisms underlying how miR-34 participates in vascular disorders. MATERIAL AND METHODS Three family members (miR-34a, miR-34b, and miR-34c) were overexpressed or silenced human smooth muscle cells (VSMCs) umbilical vein endothelial (UVECs), respectively, before proliferation apoptosis detected by using Cell...
The purpose of this article is to deeply explore the future development prospects Uzbekistan's tourism market economy. By collecting and analyzing a large amount data, combined with relevant theories, it objectively describes explains potential, growth trend, competition pattern path Uzbekistan market. This study will use mixed research method obtain data through questionnaires, in-depth interviews content analysis, statistical tools analyze interpret data. results show that economy has...
<title>Abstract</title> The Casitas B-lineage lymphoma (Cbl) family proteins are E3 ubiquitin ligases implicated in the regulation of various immune cells. However, their function macrophages remains unclear. We show that macrophage-specific deficiency Cbl-b and c-Cbl (Cbls) causes mice to die prematurely from spontaneous macrophage massive invasive lung inflammation. Mechanically, we identify Cbls functions upstream AKT Erk mediate ubiquitination degradation M-CSFR. upon M-CSF stimulation,...
Although the literature on industry-university alliances has begun to identify factors that influence performance of alliances, it gives relatively little concern behavioral characteristics firms. This paper seeks explore affect alliances. By taking a sample 136 Chinese firms, results indicated several have significant impact Resource investment and information sharing are found positive relationship with alliance performance, but no was between communication performance. It not only...
Zhengzhou, along with Xi'an, Chengdu, Chongqing and Wuhan, is one of the most important cities in inland China. It second largest city central China, after Wuhan. economic center province surrounding areas such as southeastern Shanxi southwestern Shandong. The main purpose this study to learn effect Zhengzhou industrial tourism on models well deep changing Zhengzhou’s model. result shows that relationship between significant. findings can suggest developing influences economy positively.