A5079455819- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Protein Tyrosine Phosphatases
- Bacterial Infections and Vaccines
- Air Quality and Health Impacts
- Respiratory and Cough-Related Research
- Advanced Graph Neural Networks
- Data Quality and Management
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Innovative Microfluidic and Catalytic Techniques Innovation
- SARS-CoV-2 and COVID-19 Research
- Topic Modeling
- Epigenetics and DNA Methylation
- Effects of Environmental Stressors on Livestock
- Pediatric health and respiratory diseases
Soochow University
2022-2025
Southern Medical University Shenzhen Hospital
2025
Stomatology Hospital
2025
Soochow University
2021
E3 ubiquitin ligases are key molecules in regulating the innate immune responses against virus. They catalyze activation or degradation of various signaling proteins involved responses. Herein, we found regulatory role RNF149 host's viral infection. Virus infection induced expression RNF149. Overexpression was associated with reduced production IFN-β and enhanced replication. Mechanically, interacted IRF3 downregulated its protein level. As an ligase, promoted K27-linked ubiquitination at...
The role of micro RNAs (miRNAs) in asthma remains unclear. In this study, we examined the miRNA targeting FOXO1 asthma. Results showed that miR-493-5p was one differentially expressed miRNAs PBMCs asthmatic children, and also associated with Th cell differentiation. expression decreased significantly OVA-induced mice than control groups. mimic inhibited IL-9, IRF4 FOXO1, while inhibitor restored these effects. Moreover, Dual-Luciferase analysis results as a novel valid target miR-493-5p....
Background The implementation of a zero-COVID policy for 3 years in China during the COVID-19 pandemic significantly impacted broad spectrum acute respiratory tract infections (ARTIs). epidemiological characteristics ARTI pathogens children following cessation remain unclear. Methods Etiologically diagnostic data from 82,708 with ARTIs at Children’s Hospital Soochow University 2016–2023 were analyzed 8 (human syncytial virus [HRSV], influenza A [FluA], FluB, human parainfluenza [HPIV],...
After ending the three-year zero COVID policy in China, epidemiology of other respiratory pathogens has been affected. This study aimed to characterize common pathogen infections pediatric patients hospitalized for acute tract (ARTIs) Suzhou before and after policy. Nasopharyngeal aspirates (NPAs) were obtained from children with ARTIs (aged ≤ 16 years) at Children's Hospital Soochow University detection syncytial virus (RSV), influenza A (FluA), FluB, human parainfluenza (HPIV), adenovirus...
Background: Neonate lung injury is a common phenomenon after perinatal asphyxia. Objective: To evaluate proteomic profiles of exosomes isolated from offspring serum Methods: Serum samples were collected at 12 h, 24 and 72 h birth in neonates with asphyxia-induced injury. Exosomes isolated, the concentration size distribution assessed. The exosome surface markers CD9, CD63, CD81, HSP70, TSG101 detected by Western blot. proteins evaluated quantitative proteomics using tandem mass tag (TMT)....
This study aimed to explore the effects of forkhead box P2 gene (Foxp2) on T-helper 9 (Th9) differentiation in asthmatic mice. An vivo mouse model was induced with ovalbumin (OVA). vitro established by culturing CD4+ T cells TGF-β, IL-4, and anti-IFN-γ. ELISA, flow cytometry, qRT-PCR Western blot were performed examine IL-9 secretion, Th9 cell number, transcription factor expression, respectively. Pathological changes lung tissues airway mucus secretion assessed HE PAS glycogen staining....
The aim of the study was to explore serum expression long noncoding RNA (lncRNA) growth arrest‐specific transcript 5 (GAS5) in Mycoplasma pneumoniae pneumonia (MPP) and its effect on lipid‐associated membrane proteins (LAMPs)‐induced apoptosis inflammation. Totally, 56 children with MPP (MPP group) healthy (NC were enrolled. lncRNA GAS5 measured by quantitative real‐time polymerase chain reaction (qRT‐PCR). Serum levels tumor necrosis factor α (TNF‐ ) interleukin‐6 (IL‐6) detected using...
Abstract This study aimed to establish a registry database of different treatment modalities for lower respiratory tract infections (LRTIs) in Chinese children, thereby filling gaps knowledge on clinical characteristics, modalities, and rational drug use relation LRTIs providing large amounts continuous, complete, scientific, objective data, an information exchange platform. Multicenter data from these children's visits were collected, pooled, analyzed using medical informatics statistical...
It has been demonstrated that dopamine (DA) plays an important role in numerous cellular processes of T cell. Accumulating evidence suggests the outcomes cell treatment with DA is depended on concentrations, subtypes and activation states. However, detail mechanism function or regulatory cells largely unclear.This study aims to explore mechanisms by which regulates CD4+ Tregs.T proliferation was detected using CCK-8, BrdU incorporation assay eFluor 450 labeling assay, Western blot were used...
To investigate the epidemiological characteristics of respiratory Haemophilus influenzae (HI) infection in children Suzhou, China and its association with climatic factors air pollutants.The data on pollutants Suzhou from January 2016 to December 2019 were collected. Respiratory secretions collected 7 940 acute who hospitalized during this period, bacterial culture results analyzed for detection HI. A stepwise regression analysis was used HI rate (PM2.5, PM10, NO2, SO2, CO, O3) (monthly mean...
雾化吸入疗法在儿童呼吸道疾病的管理中起着重要的作用，是学龄前儿童呼吸治疗的主要手段之一。本文针对临床雾化治疗中的常见困惑，邀请了国内部分儿科呼吸专家，以问答的形式，就雾化疗法过程中的20个常见问题达成共识，希望能够为儿童雾化疗法的规范合理使用提供帮助。.
Abstract Background: There is an increasing attention on microRNAs because of their functional effect polarization CD4 + T cells. This study explores the mechanism miR-493-5p regulating Th9 cell differentiation in allergic asthma. Methods: The airway inflammation induced by ovalbumin (OVA) mice. cells from normal mice are cultured under conditions. IL-9 levels and analyzed RT-qPCR, ELISA, flow cytometry western blot. level detected RT-qPCR. interaction between FOXO1 predicted TargetScan...