A5019135959- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Infectious Diseases and Mycology
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Thermal Regulation in Medicine
- Medical Imaging and Pathology Studies
- Cardiac electrophysiology and arrhythmias
- Sepsis Diagnosis and Treatment
- Cardiac tumors and thrombi
- RNA Interference and Gene Delivery
- SARS-CoV-2 and COVID-19 Research
- Chemokine receptors and signaling
- Inhalation and Respiratory Drug Delivery
- Vascular Tumors and Angiosarcomas
- Cancer, Stress, Anesthesia, and Immune Response
- Signaling Pathways in Disease
- Respiratory viral infections research
- ATP Synthase and ATPases Research
Jiangsu Province Hospital
2024
The University of Texas MD Anderson Cancer Center
2013-2023
Soochow University
2022
Nanjing General Hospital of Nanjing Military Command
2009-2018
Nanjing University
2009-2017
Fudan University Shanghai Cancer Center
2017
Shanghai Medical College of Fudan University
2017
Jinling Institute of Technology
2017
Air Force Medical University
2015
University of Utah
2014
The vascular endothelium responds to infection by destabilizing endothelial cell-cell junctions allow fluid and cells pass into peripheral tissues, facilitating clearance of tissue repair. During sepsis, endotoxin other proinflammatory molecules induce excessive leak, which can cause organ dysfunction, shock, death. Current therapies for sepsis are limited antibiotics supportive care, often insufficient reduce morbidity prevent mortality. Previous attempts at blocking inflammatory cytokine...
Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, term use tends to elicit its adverse reactions. The present study aimed investigate the antidepressant-like effects intermittent consecutive administrations on chronic unpredictable mild stress (CUMS) rats, determine whether can redeem time for treatment classic...
Acute fibrinous and organizing pneumonia (AFOP) is a rare lung disease with distinct histological characteristics that include the diffuse presence of intra-alveolar fibrin, absence eosinophils hyaline membrane. In present study, case AFOP was diagnosed by biopsy described. The patient presented high fever cough expectoration. Computed tomography showed bilateral patchy infiltrates, predominantly in lower lobes. Histopathological examination from pulmonary lobe confirmed pathological...
Objective We aimed to investigate the impacts of prolonged mask use on patients with hypertension or diabetes during COVID-19 pandemic. Methods This study included who visited outpatient department Nanjing Yimin Hospital between 1 February 2022 and 31 January 2023. compared change in blood pressure (BP) fasting plasma glucose adjustments treatment group mask-wearing (≥20 hours/week) control (<20 hours/week). Results Compared hypertensive patients, had significantly higher diastolic (DBP)...
Abstract Background: Inflammatory breast cancer (IBC) is a rare but aggressive tumor type accounting for up to 10% of deaths. One-third IBCs express high PD-L1 that can be targeted by atezolizumab (Az). MEK inhibitor cobimetinib (Co) not only inhibits the RAS-MAPK pathway further enhance immune-mediated killing. Thus, we hypothesize Az+Co may efficacy chemotherapy in metastatic IBC (mIBC). We opened trial test this hypothesis with comprehensive multi-omics biomarker assessment. Patients and...
The number of patients diagnosed with pulmonary nodules increased as more high risk lung cancer choose low-dose computed tomography (CT) scans for the screening cancer. Clinicians might get two questions from patients: what is definite diagnosis nodule? What should we do? We have already got many guidelines trying to solve these problems. There are also several prediction models nodules. However, not suitable all types patients, and reality complicated. Here reported a 58-year-old man nodule...
Abstract Background: Increased CD8+ tumor-infiltrating lymphocytes (TIL) is associated with improved prognosis in triple-negative breast cancer (TNBC) suggesting that T-cell responses at the tumor site can be harnessed for autologous therapy using TIL expanded ex vivo. Although has been developed solid tumors such as melanoma, cervical, and ovarian cancer. Moreover, methods facilitating expansion from TNBC are desirable given their cytotoxic potential against cells. One approach to address...
Synovial sarcoma (SS) is an uncommon and highly malignant soft tissue in the clinic, with primary pulmonary SS (PPSS) being extremely rare. Here, we describe clinical characteristics, diagnosis, treatment of a solitary PPSS case confirmed via surgical resection fluorescence situ hybridization (FISH).A 33-year-old man was admitted because intermittent coughing hemoptysis for one month, lung shadows observed two years. Whole-body positron emission tomography-computed tomography (PET-CT)...
To investigate the epidemiological characteristics of respiratory Haemophilus influenzae (HI) infection in children Suzhou, China and its association with climatic factors air pollutants.The data on pollutants Suzhou from January 2016 to December 2019 were collected. Respiratory secretions collected 7 940 acute who hospitalized during this period, bacterial culture results analyzed for detection HI. A stepwise regression analysis was used HI rate (PM2.5, PM10, NO2, SO2, CO, O3) (monthly mean...
Objective To determine the effect of dobutamine, a β-adrenergic agonist, on alveolar fluid clearance (AFC) in acute lung injury (ALI). Methods Thirty two male Sprague-Dawley rats were randomly divided into four equal groups: normal control group; ALI group, infused with endotoxin to induce ALI; dobutamine receiving sustained intravenous injection at dose 5 μg/kg/min, and treatment μg/kg/min after administration endotoxin. Experiment began 45~60 minutes circulation was stable. Blood pressure...
Abstract Background: While HER2 targeted therapeutics have significantly improved outcomes of patients with overexpressed advanced breast cancer (ABC), c-Met pathway activation serves as a resistance mechanism in about 60% patients. Neratinib is an irreversible tyrosine kinase inhibitor the ErbB family receptors (EGFR, HER2, and HER4) tepotinib c-Met. From live extracted cells from patient biopsies, CELsignia Pathway Activity Test measures real-time signaling activity dynamic response to...
Antithrombin-Ⅲ (AT-Ⅲ ),a physiological serine protease inhibitor,plays a critical role in the regulation of coagulation cascade human being.In addition to regulatory system,AT-Ⅲ exerts strong anti-inflammatory activity.This paper reviews advancement mechanism AT-Ⅲ property recent years. Key words: Antithrombin- Ⅲ ; Inflammatory reaction; Mechanism
Abstract Background: The pathologic complete response (pCR) rate in inflammatory breast cancer (IBC) patients is worse than non-IBC patients; new drug combinations are warranted to improve pCR rates across all IBC molecular subtypes. Based on our preclinical data, we added neratinib standard neoadjuvant chemotherapy both HER2+ (synergy) and HER2-/hormone receptor (HR)+ (high frequency of ERBB2 mut) untreated IBC, as a single-center, non-randomized phase I/II trial. Patients Method: This...