A5030150444- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Advanced biosensing and bioanalysis techniques
- RNA and protein synthesis mechanisms
- Cancer Risks and Factors
- Cancer survivorship and care
- Global Cancer Incidence and Screening
- Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Economic and Financial Impacts of Cancer
- Childhood Cancer Survivors' Quality of Life
- Gastric Cancer Management and Outcomes
- Breast Implant and Reconstruction
- Colorectal and Anal Carcinomas
- Family Support in Illness
- PARP inhibition in cancer therapy
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
The University of Texas MD Anderson Cancer Center
2016-2025
Breast Cancer Care
2005-2024
Cancer Genetics (United States)
2006-2017
Utah Cancer Specialists
2017
Hematology Oncology Associates
2017
NYU Langone Health
2016
Augusta University
2007-2010
The University of Texas Southwestern Medical Center
2006
<h3>Importance</h3> A pathologic complete response (pCR; no invasive or in situ cancer) occurs 40% to 50% of patients with<i>HER2</i>-positive (<i>HER2</i>+) and triple-negative (TN) breast cancer. The need for surgery if percutaneous biopsy the after neoadjuvant chemotherapy (NCT) indicates pCR (hereinafter referred as pCR) has been questioned, appropriate management axilla such is unknown. <h3>Objective</h3> To identify among exceptional responders NCT with a low risk axillary metastases...
Talazoparib has demonstrated efficacy in patients with BRCA-positive metastatic breast cancer. This study evaluated the pathologic response of talazoparib alone for 6 months a known germline BRCA pathogenic variant (gBRCA-positive) and operable cancer.Eligibility included 1 cm or larger invasive tumor gBRCA-positive disease. Human epidermal growth factor receptor 2-positive tumors were excluded. Twenty underwent pretreatment biopsy, once per day oral (1 mg), followed by definitive surgery....
We investigated differences in smoking behaviors between US-and Mexican-born ever smokers and examined the influence of US culture on initiation.Participants were 5030 adults Mexican descent enrolled an ongoing population-based cohort Houston, Tex.More men than women reported current smoking; rates among US-born higher those women. Smoking earlier published Hispanics non-Hispanic Whites but similar to African Americans. Current lower for Hispanics, Whites, Older age, male gender, a level...
Abstract Objective: To evaluate the association between birthplace (Mexico or U.S.) and obesity in men women to analyze relationship duration of U.S. residency prevalence Mexican immigrants. Research Methods Procedures: We used cross‐sectional data from 7503 adults descent residing Harris County, TX, relationships among BMI, birthplace, years U.S., controlling for demographic characteristics, physical activity level, acculturation level. Results: U.S.‐born had an increased risk (between 34%...
Purpose To compare the risk of hospitalization between patients with early-stage breast cancer who received different chemotherapy regimens. Patient and Methods We identified 3,567 older than age 65 years from SEER/Texas Cancer Registry-Medicare database 9,327 younger MarketScan were diagnosed 2003 2007. The selection was nonrandomized nonprospectively collected. categorized according to regimens they received: docetaxel (T) cyclophosphamide (C), doxorubicin (A) C, TAC, AC + T, dose-dense...
We counsel our triple-negative breast cancer (TNBC) patients that the risk of recurrence is highest in first 5 years after diagnosis. However, there are limited data with extended follow-up on frequency, characteristics, and predictors late events. queried MD Anderson Breast Cancer Management System database to identify stage I–III TNBC who were disease free at from The Kaplan–Meier method was used estimate yearly recurrence-free interval (RFI), survival (RFS), distant relapse-free (DRFS),...
The aim of this study was to compare clinical and pathological outcomes after neoadjuvant chemotherapy between oestrogen receptor (ER)-positive invasive pure lobular carcinoma (ILC) ductal (IDC). This analysis included 1895 patients (n=177 ILC; n=1718 IDC), with stage I–III breast cancer, who received chemotherapy. Clinical response rates, the frequency positive surgical margins rate breast-conserving surgery were compared. There a trend for fewer good responses in ILC compared IDC. Tumour...
Purpose Carrier prediction models estimate the probability that a person has BRCA mutation. We evaluated accuracy of BOADICEA model and compared its performance with other (BRCAPRO, Myriad I II, Couch, Manchester Scoring System). also studied effect extended family information on risk estimation using BOADICEA. Methods area under receiver operating characteristic curves generated from 472 families one member tested for mutations. calculated sensitivity, specificity, predictive values at an...
This study was undertaken to determine the feasibility of enrolling breast cancer patients on a single-agent-targeted therapy trial before neoadjuvant chemotherapy. Specifically, we evaluated talazoparib in harboring deleterious BRCA mutation (BRCA+). Patients with germline and ≥1 cm, HER2-negative primary tumors were eligible. Study participants underwent pretreatment biopsy, 2 months talazoparib, off-study core anthracycline, taxane-based chemotherapy ± carboplatin, followed by surgery....
BACKGROUND The objective of this study was to determine patient characteristics associated with potentially inappropriate medication (PIM) use and its impact on outcomes for patients breast or colorectal cancer receiving adjuvant chemotherapy. METHODS Surveillance, Epidemiology, End Results database, linked Medicare claims, used. cohort included who were 66 years old older diagnosed stage II III between July 1, 2007, December 31, 2009. Drugs Avoid in the Elderly (DAE) list Beers criteria...
In this study, we developed integrative, personalized prognostic models for breast cancer recurrence and overall survival (OS) that consider receptor subtypes, epidemiological data, quality of life (QoL), treatment.A total 15 314 women with stage I to III invasive primary treated at The University Texas MD Anderson Cancer Center between 1997 2012 were used generate by Cox regression analysis in a two-stage study. Model performance was assessed calculating the area under curve (AUC)...
Atypical femoral fractures (AFFs) are rare adverse events attributed to bisphosphonate (BP) use. Few cases of AFF in cancer have been described; the aim this study is identify incidence and risk factors for a large center. This retrospective was conducted at MD Anderson Cancer Center. The rate among BP users calculated from January 1, 2004 through December 31, 2013. control group (n = 51) included 2 or 3 patients on BPs matched age (≤1 year) gender. Logistic regression analysis used assess...
Abstract Background Delays in the initiation of therapy among patients with early stage breast cancer (BC) can negatively affect outcomes. Patients treated neoadjuvant systemic chemotherapy (NSC) usually display tumors high-risk features. Considering these characteristics and evidence supporting adverse outcomes associated delays adjuvant initiation, we sought to determine whether a delay NSC is overall survival (OS). Methods We identified diagnosed between January 1995 December 2015...
Background Although there are a growing number of survivors adolescent and young adult (AYA) cancer, to the authors' knowledge long‐term overall survival (OS) patterns for AYA cancer underreported. The objective current study was assess identify factors associated with diminished survival. Methods authors used University Texas MD Anderson Cancer Center's tumor registry 5‐year diagnosed as AYAs (ages 15‐39 years) between years 1970 2005, who were alive 5 after diagnosis. Kaplan‐Meier curves...
Abstract Background Triple negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. We aimed to determine whether circulating tumor DNA (ctDNA) and cell (CTC) could predict response long-term outcomes neoadjuvant chemotherapy (NAC). Methods Patients TNBC were enrolled between 2017–2021 at The University of Texas MD Anderson Cancer Center (Houston, TX). Serial plasma samples collected four timepoints: pre-NAC (baseline), 12-weeks after NAC (mid-NAC), NAC/prior surgery...
Abstract Background Wood dust was designated as a human carcinogen based on increased sinus and nasal cancer rates among exposed workers. However, data an association with lung have been inconclusive. Methods Self‐reported wood exposure compared between 1,368 patients 1,192 cancer‐free adults, in case‐control study. Epidemiological information collected through detailed personal interview. Results Using several definitions of we consistently observed statistically significant elevated...
Abstract Objective: The goal of this study was to evaluate the relationship between maternal and childhood BMI at baseline in a group 5‐ 18‐year‐old children their mothers, all whom were Mexican origin, low socioeconomic status, enrolled cohort Houston, TX. Research Methods Procedures: Using data from 438 mother‐child dyads residing same household, we completed logistic regression analyses determine factors associated with child being overweight or at‐risk‐for‐overweight, after adjusting for...
Abstract Background An increasing proportion of human epidermal growth receptor 2 (HER2) positive (HER2+) metastatic breast cancer (MBC) is diagnosed as de novo stage IV disease. We hypothesize that a subset these patients who achieve no evidence disease (NED) status after multimodality HER2-targeted treatments may have prolonged progression-free survival (PFS) and overall (OS). Materials Methods Patients with IV, HER2+ MBC (n = 483) between 1998 2015 were identified at two institutions...